Professor Lang is a consultant cardiologist and clinical pharmacologist and Professor of Cardiology at Ninewells Hospital and Medical School, Dundee, United Kingdom. He trained in both cardiology and clinical pharmacology in the United Kingdom and in the United States where he was a Merck International Fellow in Clinical Pharmacology at Vanderbilt University, Nashville and a Fulbright Scholar at Columbia University, New York. He is a Fellow of the Royal Colleges of Physicians of London and Edinburgh and the American College of Cardiology.
His research takes a multi-disciplinary approach to the understanding of the pathophysiology and pharmacogenetics of cardiovascular diseases and to the development of treatment strategies in patients with cardiovascular diseases. He leads an integrated cardiovascular research laboratory dedicated and equipped to the study of cardiac and vasomotor regulation. These techniques are applied towards translational research and in the development of biomarkers and novel treatment strategies in patients with cardiovascular diseases. Prof Lang is the Work Package Lead for the validation cohort for the FP-7 funded BIOSTAT-CHF study that aims optimize the treatment of heart failure for each individual using information from genomics and proteomics. A wide range of funding bodies including the British Heart Foundation, MRC, Chief Scientist Office, Chest Heart and Stroke Scotland, Tenovus and the European commission Seventh Framework Programme (FP-7) funds his research.
'Potential mechanisms for the effects of far-infrared on the cardiovascular system – a review' VASA.
'Potential mechanisms for the eff ects of far-infrared on the cardiovascular system: a review' VASA.
'Clinical correlates and outcome associated with changes in 6-Minute Walking Distance in Patients with Heart Failure: findings from the BIOSTAT-CHF study' European Journal of Heart Failure.
'Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure' vol. 15, 35, pp. 1-9.
'Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF)' European Journal of Heart Failure.
'Heart failure in the outpatient versus inpatient setting: findings from the BIOSTAT-CHF study' European Journal of Heart Failure.
'The effects and costs of home-based rehabilitation for heart failure with reduced ejection fraction: the REACH-HF multicenter randomized controlled trial' European Journal of Preventive Cardiology.
'What is the added value of the waist-to-hip ratio on top of the BIOSTAT risk prediction model in patients with heart failure? Reply' European Journal of Heart Failure.
'Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction' Journal of the American College of Cardiology, vol. 72, no. 10, pp. 1081-1090.
'Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction' European Heart Journal.
'Non-cardiac Comorbidities in Heart Failure with Reduced, Mid-range and Preserved Ejection Fraction' International journal of cardiology.
'Iron Therapy in Heart Failure: Ready for Primetime?' Cardiac Failure Review, vol. 4, no. 1, pp. 28-32.
'A Randomised Controlled Trial of a Facilitated Home-Based Rehabilitation Intervention in Patients with Heart Failure with Preserved Ejection Fraction and their Caregivers: REACH-HFp EF Pilot Study' BMJ Open, vol. 8, no. 4, e019649.
'Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (Go DARTS)' International Journal of Epidemiology, vol. 47, no. 2, pp. 380-381j.
'Coronary angiography in worsening heart failure: determinants, findings, and prognostic implications' Heart, vol. 104, no. 7, pp. 606-613.
'Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure' International journal of cardiology, vol. 253, pp. 84-90.
'Epicardial Adipose Tissue Is Related to Arterial Stiffness and Inflammation in Patients with Cardiovascular Disease and Type 2 Diabetes' BMC Cardiovascular Disorders, vol. 18, 31, pp. 1-8.
'Repurposing metformin for cardiovascular disease' Circulation, vol. 137, no. 5, pp. 422-424.
'Biomarker-guided Versus Evidence-based Treatment in Heart Failure: Results From BIOSTAT-CHF' Journal of the American College of Cardiology, vol. 71, no. 4, pp. 386-398.
'Potassium and the use of renin–angiotensin–aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT-CHF' European Journal of Heart Failure.
'The APEX Trial: Effects of Allopurinol on Exercise Capacity, Coronary and Peripheral Endothelial Function and Natriuretic Peptides in Patients with Cardiac Syndrome X' Cardiovascular Therapeutics, vol. 36, no. 1, e12311.
'Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure' European Journal of Heart Failure.
'Symptom Onset in Aortic Stenosis - Relation to Sex Differences in Left Ventricular Remodelling' JACC. Cardiovascular Imaging.
'Efficacy of noninvasive cardiac imaging tests in diagnosis and management of stable coronary artery disease' Vascular Health and Risk Management, vol. 13, pp. 427-437.
'The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure: BIOSTAT-CHF Subanalysis' Journal of the American College of Cardiology, vol. 70, no. 17, pp. 2128-2136.
'Mineralocorticoid receptor antagonist pattern of use in heart failure with reduced ejection fraction: findings from BIOSTAT-CHF' European Journal of Heart Failure, vol. 19, no. 10, pp. 1284-1293.
'Renal and Cardiovascular Effects of sodium–glucose cotransporter 2 (SGLT2) inhibition in combination with loop Diuretics in diabetic patients with Chronic Heart Failure (RECEDE-CHF): protocol for a randomised controlled double-blind cross-over trial' BMJ Open, vol. 7, no. 10, e018097, pp. 1-10.
'Sacubitril/valsartan: beyond natriuretic peptides' Heart, vol. 103, no. 20, pp. 1569-1577.
'Cardiac rehabilitation in heart failure with reduced ejection fraction: A "should take it and not leave it" intervention' American Heart Journal, vol. 192, pp. e1-e2.
'Sacubitril and valsartan fixed combination to reduce heart failure events in post-acute myocardial infarction patients' Drugs of Today , vol. 53, no. 10, pp. 545-551.
'Iron Deficiency in Heart Failure: Efficacy and safety of intravenous iron therapy' Cardiovascular Therapeutics, vol. 35, no. 6, e12301, pp. 1-8.
'Does dapagliflozin regress left ventricular hypertrophy in patients with type 2 diabetes? A prospective, double-blind, randomised, placebo-controlled study' BMC Cardiovascular Disorders, vol. 17, 229, pp. 1-12.
'Determinants and clinical outcome of uptitration of ACE-inhibitor and beta-blocker in patients with heart failure: a prospective European study' European Heart Journal, vol. 38, no. 24, pp. 1883-1890b.
'Population-Level Incidence and Monitoring of Adverse Drug Reactions with Long-term Amiodarone Therapy' Cardiovascular Therapeutics, vol. 35, no. 3, e12258, pp. 1-7.
'Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure' Diseases, vol. 5, no. 2, 14, pp. 1-18.
'Development and validation of multivariable models to predict mortality and hospitalization in patients with heart failure' European Journal of Heart Failure, vol. 19, no. 5, pp. 627-634.
'Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in Aortic Stenosis (PRIMID AS) study' European Heart Journal, vol. 38, no. 16, pp. 1222-1229.
'Genetic variation in Kruppel like factor 15 is associated with left ventricular hypertrophy in patients with type 2 diabetes: discovery and replication cohorts ' EBio Medicine, vol. 18, pp. 171-178.
'Adverse prognosis associated with asymmetric myocardial thickening in aortic stenosis' European Heart Journal - Cardiovascular Imaging.
'Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors' Pharmacogenetics and Genomics, vol. 27, no. 3, pp. 112-119.
'Rehabilitation Enablement in Chronic Heart Failure—a facilitated self-care rehabilitation intervention in patients with heart failure with preserved ejection fraction (REACH-HFp EF) and their caregivers: rationale and protocol for a single-centre pilot randomised controlled trial' BMJ Open, vol. 6, no. 10, e012853, pp. 1-11.
'Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status' Circulation Research, vol. 119, no. 5, pp. 652-665.
'Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design' Cardiovascular Diabetology, vol. 15, 97, pp. 1-11.
'A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure: Rationale, design, and baseline characteristics of BIOSTAT-CHF' European Journal of Heart Failure, vol. 18, no. 6, pp. 716-726.
'Meet our editorial board member' Current Clinical Pharmacology, vol. 11, no. 2, pp. 71.
Publication process. in S Ray, S Fitzpatrick, R Gloubic & S Fisher (eds), Oxford Handbook of Clinical and Healthcare Research. Oxford Medical Handbooks, Oxford University Press, United Kingdom.
'Obituary' Cardiovascular Therapeutics, vol. 34, no. 1, pp. 3.
'Mean Hb A1c and mortality in diabetic individuals with heart failure: a population cohort study' European Journal of Heart Failure, vol. 18, no. 1, pp. 94-102.
'The role of cardiac biochemical markers in aortic stenosis' Biomarkers, vol. 21, no. 4, pp. 316-327.
'The future of pharmacogenetics in the treatment of heart failure' Pharmacogenomics, vol. 16, no. 16, pp. 1817-1827.
'Management of noncardiac comorbidities in chronic heart failure' Cardiovascular Therapeutics, vol. 33, no. 5, pp. 300-315.
'Underutilisation of IV nitrates in the treatment of acute heart failure' Cardiovascular Therapeutics, vol. 33, no. 4, pp. 247-252.
'Characterizing patients with chronic heart failure in community care after hospitalization: a potential role for ivabradine' Cardiovascular Therapeutics, vol. 33, no. 3, pp. 104-108.
'Both high and low Hb A1c predict incident heart failure in type 2 diabetes mellitus' Circulation: Heart Failure, vol. 8, no. 2, pp. 236-242.
'An increased B-type natriuretic peptide in the absence of a cardiac abnormality identifies those whose left ventricular mass will increase over time' JACC: Heart Failure, vol. 3, no. 1, pp. 87-93.
'Effect of warfarin on survival in patients with concomitant left ventricular systolic dysfunction and pulmonary hypertension: a population cohort study' European Journal of Heart Failure, vol. 17, no. 1, pp. 90-7.
'Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond' Vascular Health and Risk Management, vol. 11, pp. 283-295.
'Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome' Future Cardiology, vol. 10, no. 6, pp. 693-698.
'High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis' European Heart Journal, vol. 35, no. 34, pp. 2312-2321.
'Nurse-led Early Triage (NET) study of chest pain patients: a long term evaluation study of a service development aimed at improving the management of patients with non-ST-elevation acute coronary syndromes' European Journal of Cardiovascular Nursing, vol. 13, no. 3, pp. 253-260.
'60 insulin resistance is associated with all-cause mortality and accelerates the risk of progression to diabetes in non-diabetic heart failure patients' Heart, vol. 100 , no. s3, pp. A34.
'Discovering new biomarkers for predicting treatment response in heart failure using plasma proteomics' Heart (British Cardiac Society), vol. 100 , no. Suppl 3, pp. A30.
'Modulation of the Renin-Angiotensin-aldosterone system in heart failure' Current Atherosclerosis Reports, vol. 16, no. 4, pp. 403.
'The impact of age and chronic kidney disease on secondary prevention post-primary percutaneous coronary intervention' QJM : an International Journal of Medicine, vol. 107, no. 3, pp. 185-192.
'Myocardial ischaemia is associated with an elevated brain natriuretic pepide level even in the presence of left ventricular systolic dysfunction' European Journal of Heart Failure, vol. 16, no. 1, pp. 56-67.
'High-potency statin and ezetimibe use and mortality in survivors of an acute myocardial infarction: a population-based study' Heart, vol. 100, no. 11, pp. 867-872.
'Novel Blockers of the Renin-Angiotensin-Aldosterone System in Chronic Heart Failure' Current Heart Failure Reports.
'Renin-Angiotensin-aldosterone system inhibitors in heart failure' Clinical Pharmacology & Therapeutics, vol. 94, no. 4, pp. 459-467.
'Effects of Vitamin D supplementation on markers of vascular function after myocardial infarction: A randomised controlled trial' International journal of cardiology, vol. 167, no. 3, pp. 745-749.
'Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis' Cardiovascular Diabetology, vol. 12, 109.
'High-Dose Allopurinol reduces left ventricular mass in patients with ischemic heart disease' Journal of the American College of Cardiology, vol. 61, no. 9, pp. 926-32.
'Targeting the renin-angiotensin-aldosterone system in heart failure' Nature reviews. Cardiology, vol. 10, pp. 125-134.
'Is thiazolidinedione treatment an important cause of oedema?' Diabetic Medicine, vol. 30, no. Suppl. 1, P562, pp. 197-197.
'Aortic valvular heart disease: is there a place for angiotensin-converting-enzyme inhibitors?' Expert Review of Cardiovascular Therapy, vol. 11, no. 1, pp. 107-14.
'Mind your language: conveying the results of clinical trials of cardiovascular therapies' Cardiovascular Therapeutics, vol. 31, no. 1, pp. 1.
'Is thiazolidinedione treatment an important cause of oedema?' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .
'Glycaemic control and the development of heart failure' Journal of the American College of Cardiology, vol. 61, no. 10 Supplement, pp. E566.
'Genetic variants predicting left ventricular hypertrophy in a diabetic population' Journal of the American College of Cardiology, vol. 61, no. 10 Supplement, pp. E598.
'Allopurinol reduces left ventricular mass in patients with type ii diabetes and left ventricular hypertrophy' Journal of the American College of Cardiology, vol. 61, no. 10 Supplement, pp. E1256.
'State of play of pharmacogenetics and personalized medicine in heart failure' Cardiovascular Therapeutics, vol. 31, no. 6, pp. 315-322.
'The effect of metformin on insulin resistance and exercise parameters in patients with heart failure' European Journal of Heart Failure, vol. 14, no. 11, pp. 1303-1310.
'Improving the primary prevention of cardiovascular events by using biomarkers to identify individuals with silent heart disease' Journal of the American College of Cardiology, vol. 60, no. 11, pp. 960-968.
'High dose allopurinol reduces left ventricular hypertrophy and improves endothelial function in patients with chronic stable angina' European Heart Journal, vol. 33, no. S1, pp. 350-350.
'Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block' Heart Rhythm : the Official Journal of the Heart Rhythm Society, vol. 9, no. 4, pp. 505-510.
'High sensitivity troponin T provides useful prognostic information in non-acute chest pain' QJM : an International Journal of Medicine, vol. 105, no. 2, pp. 159-166.
'Does vitamin D supplementation improve markers of vascular health in post myocardial infarction patients? a randomised controlled trial' Age and Ageing, vol. 41, no. Supplement 1, pp. i10-i10.
'Pulmonary hypertension predicts all-cause mortality in patients with heart failure: a retrospective cohort study' European Journal of Heart Failure, vol. 14, no. 2, pp. 162-167.
'Large and small artery endothelial dysfunction in chronic fatigue syndrome' International journal of cardiology, vol. 154, no. 3, pp. 335-336.
'Efficacy and cost of an exercise program for functionally impaired older patients with heart failure: a randomized controlled trial' Circulation: Heart Failure, vol. 5, no. 2, pp. 209-216.
'The prognostic significance of early and late anaemia in acute coronary syndrome' QJM : an International Journal of Medicine, vol. 105, no. 5, pp. 445-454.
'The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome' Heart, vol. 98, no. 15, pp. 1160-5.
'B-type natriuretic peptide is an independent predictor of endothelial function in man' Clinical Science, vol. 123, no. 5, pp. 307-312.
'Automated data capture from echocardiography reports to enhance hart failure population research' Heart, vol. 98, no. Suppl. 1, pp. A10-A10.
'HBA1C and mortality in diabetic individuals with heart failure: an observational cohort study' Heart, vol. 98, no. Suppl. 1, pp. A9-A10.
'Discontinuation of beta-blockers in cardiovascular disease: UK primary care cohort study' International journal of cardiology, vol. 167, no. 6, pp. 2695-2699.
'Insulin sensitization therapy and the heart: focus on metformin and thiazolidinediones' Heart Failure Clinics, vol. 8, no. 4, pp. 539-50.
'Resting heart rate and outcomes in patients with cardiovascular disease: where do we currently stand?' Cardiovascular Therapeutics, vol. 31, no. 4, pp. 215-223.
'High Sensitivity Cardiac Troponin T is Associated with Silent Cardiac Target Organ Damage in Asymptomatic Primary Prevention Patients' Circulation, vol. 124, no. 21, pp. -.
'Warfarin Use is Associated With Reduced Mortality in Patients with Left Ventricular Systolic Dysfunction and Pulmonary Hypertension Ventricular Systolic Dysfunction and Pulmonary Hypertension' Circulation, vol. 124, no. 21, pp. -.
'The impact of renin-angiotensin-aldosterone system blockade on heart failure outcomes and mortality in patients identified to have aortic regurgitation: a large population cohort study' Journal of the American College of Cardiology, vol. 58, no. 20, pp. 2084-2091.
Exercise intolerance in heart failure’ 2nd Asian Pacific Congress of Heart Failure, Singapore
Diabetes UK Professional Conference 2013
Activity: Participation in conference
98th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
Activity: Participation in conference