Chim Lang

+44 (0)1382 383013
Head of Division - Molecular & Clinical Medicine & Professor of Cardiology

Bio

Teaching

Full contribution to teaching in Dundee, especially cardiology and clinical pharmacology. Member of Undergraduate Medical School Assessment Committee. External undergraduate examinerships (National University of Singapore, University of Malaya, International Medical University, Malaysia, National University of Malaysia). Supervisor of 25 MD/PhDs personally. External examiner for MD (Universities of Birmingham, Cardiff, Edinburgh, Glasgow)

Biography

Professor Lang is a consultant cardiologist and clinical pharmacologist and Professor of Cardiology at Ninewells Hospital and Medical School, Dundee, United Kingdom. He trained in both cardiology and clinical pharmacology in the United Kingdom and in the United States where he was a Merck International Fellow in Clinical Pharmacology at Vanderbilt University, Nashville and a Fulbright Scholar at Columbia University, New York. He is a Fellow of the Royal Colleges of Physicians of London and Edinburgh and the American College of Cardiology.

Research

His research takes a multi-disciplinary approach to the understanding of the pathophysiology and pharmacogenetics of cardiovascular diseases and to the development of treatment strategies in patients with cardiovascular diseases. He leads an integrated cardiovascular research laboratory dedicated and equipped to the study of cardiac and vasomotor regulation. These techniques are applied towards translational research and in the development of biomarkers and novel treatment strategies in patients with cardiovascular diseases. Prof Lang is the Work Package Lead for the validation cohort for the FP-7 funded BIOSTAT-CHF study that aims optimize the treatment of heart failure for each individual using information from genomics and proteomics. A wide range of funding bodies including the British Heart Foundation, MRC, Chief Scientist Office, Chest Heart and Stroke Scotland, Tenovus and the European commission Seventh Framework Programme (FP-7) funds his research. 

Publications

Shemilt, R, Bagabir, H, Lang, C & Khan, F 2018,

'Potential mechanisms for the effects of far-infrared on the cardiovascular system – a review' VASA.
https://doi.org/10.1024/0301-1526/a000752

Research output: Contribution To Journal



Shemilt, R, Bagabir, H, Lang, C & Khan, F 2018,

'Potential mechanisms for the eff ects of far-infrared on the cardiovascular system: a review' VASA.
https://doi.org/10.1024/0301-1526/a000752

Research output: Contribution To Journal



Ferreira, JP, Metra, M, Anker, SD, Dickstein, K, Lang, C, Ng, LL, Samani, NJ, Cleland, JGF, van Veldhuisen, DJ, Voors, AA & Zannad, F 2018,

'Clinical correlates and outcome associated with changes in 6-Minute Walking Distance in Patients with Heart Failure: findings from the BIOSTAT-CHF study' European Journal of Heart Failure.

Research output: Contribution To Journal



Cao, TH, Jones, DJL, Quinn, PA, Chan, DCS, Hafid, N, Parry, HM, Mohan, M, Sandhu, JK, Anker, SD, Cleland, JG, Dickstein, K, Filippatos, G, Hillege, HL, Metra, M, Ponikowski, P, Samani, NJ, Van Veldhuisen, DJ, Zannad, F, Zwinderman, AH, Voors, AA, Lang, CC & Ng, LL 2018,

'Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure' vol. 15, 35, pp. 1-9.
https://doi.org/10.1186/s12014-018-9213-1

Research output: Contribution To Journal



Suzuki, T, Yazaki, Y, Voors, AA, Jones, DJL, Chan, DCS, Anker, SD, Cleland, JGF, Dickstein, K, Filippatos, GS, Hillege, HL, Lang, C, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zannad, F, Zwinderman, AH, Metra, M & Ng, LL 2018,

'Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF)' European Journal of Heart Failure.
https://doi.org/10.1002/ejhf.1338

Research output: Contribution To Journal



Ferreira, JP, Metra, M, Mordi, I, Gregson, J, ter Maaten, J, Tromp, J, Anker, SD, Dickstein, K, Hillege, HL, Ng, LL, van Veldhuisen, DJ, Lang, CC, Voors, AA & Zannad, F 2018,

'Heart failure in the outpatient versus inpatient setting: findings from the BIOSTAT-CHF study' European Journal of Heart Failure.
https://doi.org/10.1002/ejhf.1323

Research output: Contribution To Journal



Dalal, HM, Taylor, RS, Jolly, K, Davis, RC, Doherty, P, Miles, J, Van Lingen, R, Warren, FC, Green, C, Wingham, J, Greaves, C, Sadler, S, Hillsdon, M, Abraham, C, Britten, N, Frost, J, Singh, S, Hayward, C, Eyre, V, Paul, K, Lang, C & Smith, K 2018,

'The effects and costs of home-based rehabilitation for heart failure with reduced ejection fraction: the REACH-HF multicenter randomized controlled trial' European Journal of Preventive Cardiology.
https://doi.org/10.1177/2047487318806358

Research output: Contribution To Journal



Streng, KW, Lang, CC & Voors, AA 2018,

'What is the added value of the waist-to-hip ratio on top of the BIOSTAT risk prediction model in patients with heart failure? Reply' European Journal of Heart Failure.
https://doi.org/10.1002/ejhf.1324

Research output: Contribution To Journal



Tromp, J, Westenbrink, D, Ouwerkerk, W, van Veldhuisen, DJ, Samani, NJ, Ponikowski, P, Metra, M, Anker, SD, Cleland, JGF, Dickstein, K, Filippatos, GS, van der Harst, P, Lang, C, Ng, LL, Zannad, F, Zwinderman, AH, Hillege, HL, van der Meer, P & Voors, AA 2018,

'Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction' Journal of the American College of Cardiology, vol. 72, no. 10, pp. 1081-1090.
https://doi.org/10.1016/j.jacc.2018.06.050

Research output: Contribution To Journal



Santema, BT, Kloosterman, M, Van Gelder, IC, Mordi, I, Lang, C, Lam, CSP, Anker, SD, Cleland, JGF, Dickstein, K, Filippatos, GS, van der Harst, P, Hillege, HL, ter Maaten, JM, Metra, M, Ng, LL, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zwinderman, AH, Zannad, F, Damman, K, van der Meer, P, Rienstra, M & Voors, AA 2018,

'Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction' European Heart Journal.
https://doi.org/10.1093/eurheartj/ehy421

Research output: Contribution To Journal



Streng, KW, Nauta, JF, Hillege, HL, Anker, SD, Cleland, JGF, Dickstein, K, Filippatos, GS, Lang, C, Metra, M, Ng, L, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zwinderman, AH, Zannad, F, Damman, K, van der Meer, P & Voors, AA 2018,

'Non-cardiac Comorbidities in Heart Failure with Reduced, Mid-range and Preserved Ejection Fraction' International journal of cardiology.
https://doi.org/10.1016/j.ijcard.2018.04.001

Research output: Contribution To Journal



Mordi, I, Tee, A & Lang, C 2018,

'Iron Therapy in Heart Failure: Ready for Primetime?' Cardiac Failure Review, vol. 4, no. 1, pp. 28-32.
https://doi.org/10.15420/cfr.2018:6:2

Research output: Contribution To Journal



REACH-HF 2018,

'A Randomised Controlled Trial of a Facilitated Home-Based Rehabilitation Intervention in Patients with Heart Failure with Preserved Ejection Fraction and their Caregivers: REACH-HFp EF Pilot Study' BMJ Open, vol. 8, no. 4, e019649.
https://doi.org/10.1136/bmjopen-2017-019649

Research output: Contribution To Journal



Hébert, HL, Shepherd, B, Milburn, K, Veluchamy, A, Meng, W, Carr, F, Donnelly, LA, Tavendale, R, Leese, G, Colhoun, HM, Dow, E, Morris, AD, Doney, AS, Lang, CC, Pearson, ER, Smith, BH & Palmer, CNA 2018,

'Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (Go DARTS)' International Journal of Epidemiology, vol. 47, no. 2, pp. 380-381j.
https://doi.org/10.1093/ije/dyx140

Research output: Contribution To Journal



Ferreira, JP, Rossignol, P, Demissei, B, Sharma, A, Girerd, N, Anker, SD, Cleland, JGF, Dickstein, K, Filippatos, GS, Hillege, HL, Lang, CC, Metra, M, Ng, L, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zwinderman, AH, Voors, AA & Zannad, F 2018,

'Coronary angiography in worsening heart failure: determinants, findings, and prognostic implications' Heart, vol. 104, no. 7, pp. 606-613.
https://doi.org/10.1136/heartjnl-2017-311750

Research output: Contribution To Journal



Ter Maaten, JM, Voors, AA, Damman, K, van der Meer, P, Anker, SD, Cleland, JG, Dickstein, K, Filippatos, G, van der Harst, P, Hillege, HL, Lang, CC, Metra, M, Navis, G, Ng, L, Ouwerkerk, W, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zannad, F, Zwinderman, AH & de Borst, MH 2018,

'Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure' International journal of cardiology, vol. 253, pp. 84-90.
https://doi.org/10.1016/j.ijcard.2017.10.010

Research output: Contribution To Journal



Al-Talabany, S, Mordi, I, Houston, JG, Colhoun, HM, Weir-Mc Call, JR, Matthew, SZ, Looker, HC, Levin, D, Belch, JJF, Dove, F, Khan, F & Lang, CC 2018,

'Epicardial Adipose Tissue Is Related to Arterial Stiffness and Inflammation in Patients with Cardiovascular Disease and Type 2 Diabetes' BMC Cardiovascular Disorders, vol. 18, 31, pp. 1-8.
https://doi.org/10.1186/s12872-018-0770-z

Research output: Contribution To Journal



Rena, G & Lang, CC 2018,

'Repurposing metformin for cardiovascular disease' Circulation, vol. 137, no. 5, pp. 422-424.
https://doi.org/10.1161/CIRCULATIONAHA.117.031735

Research output: Contribution To Journal



Ouwerkerk, W, Zwinderman, AH, Ng, LL, Demissei, B, Hillege, HL, Zannad, F, van Veldhuisen, DJ, Samani, NJ, Ponikowski, P, Metra, M, ter Maaten, JM, Lang, C, van der Harst, P, Filippatos, GS, Dickstein, K, Cleland, JGF, Anker, SD & Voors, AA 2018,

'Biomarker-guided Versus Evidence-based Treatment in Heart Failure: Results From BIOSTAT-CHF' Journal of the American College of Cardiology, vol. 71, no. 4, pp. 386-398.
https://doi.org/10.1016/j.jacc.2017.11.041

Research output: Contribution To Journal



Beusekamp, JC, Tromp, J, van der Wal, HH, Anker, SD, Cleland, JG, Dickstein, K, Filippatos, G, van der Harst, P, Hillege, HL, Lang, CC, Metra, M, Ng, LL, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zwinderman, AH, Rossignol, P, Zannad, F, Voors, AA & van der Meer, P 2018,

'Potassium and the use of renin–angiotensin–aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT-CHF' European Journal of Heart Failure.
https://doi.org/10.1002/ejhf.1079

Research output: Contribution To Journal



Lim, TK, Noman, A, Choy, AMJ, Khan, F, Struthers, AD & Lang, CC 2018,

'The APEX Trial: Effects of Allopurinol on Exercise Capacity, Coronary and Peripheral Endothelial Function and Natriuretic Peptides in Patients with Cardiac Syndrome X' Cardiovascular Therapeutics, vol. 36, no. 1, e12311.
https://doi.org/10.1111/1755-5922.12311

Research output: Contribution To Journal



Emmens, JE, Jones, DJL, Cao, TH, Chan, DCS, Romaine, SPR, Quinn, PA, Anker, SD, Cleland, JGF, Dickstein, K, Filippatos, GS, Hillege, HL, Lang, C, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zannad, F, Zwinderman, AH, Metra, M, de Boer, RA, Voors, AA & Ng, LL 2017,

'Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure' European Journal of Heart Failure.
https://doi.org/10.1002/ejhf.1101

Research output: Contribution To Journal



Singh, A, Chan, DCS, Greenwood, JP, Dawson, D, Sonecki, P, Hogrefe, K, Kelly, DJ, Dhakshinamurthy, V, Lang, C, Khoo, JP, Sprigings, D, Steeds, RP, Zhang, R, Ford, I, Jerosch-Herold, M, Yang, J, Li, Z, Ng, LL & Mc Cann, GP 2017,

'Symptom Onset in Aortic Stenosis - Relation to Sex Differences in Left Ventricular Remodelling' JACC. Cardiovascular Imaging.
https://doi.org/10.1016/j.jcmg.2017.09.019

Research output: Contribution To Journal



Mordi, IR, Badar, AA, Irving, RJ, Weir-Mc Call, JR, Houston, JG & Lang, CC 2017,

'Efficacy of noninvasive cardiac imaging tests in diagnosis and management of stable coronary artery disease' Vascular Health and Risk Management, vol. 13, pp. 427-437.
https://doi.org/10.2147/VHRM.S106838

Research output: Contribution To Journal



Bayes-Genis, A, Núñez, J, Zannad, F, Ferreira, JP, Anker, SD, Cleland, JGF, Dickstein, K, Filippatos, GS, Lang, CC, Ng, L, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zwinderman, AH, Metra, M, Lupón, J & Voors, AA 2017,

'The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure: BIOSTAT-CHF Subanalysis' Journal of the American College of Cardiology, vol. 70, no. 17, pp. 2128-2136.
https://doi.org/10.1016/j.jacc.2017.08.057

Research output: Contribution To Journal



Ferreira, JP, Rossignol, P, Machu, J-L, Sharma, A, Girerd, N, Anker, SD, Cleland, JGF, Dickstein, K, Filippatos, GS, Hillege, HL, Lang, CC, ter Maaten, JM, Metra, M, Ng, L, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zwinderman, AH, Voors, AA & Zannad, F 2017,

'Mineralocorticoid receptor antagonist pattern of use in heart failure with reduced ejection fraction: findings from BIOSTAT-CHF' European Journal of Heart Failure, vol. 19, no. 10, pp. 1284-1293.
https://doi.org/10.1002/ejhf.900

Research output: Contribution To Journal



Mordi, NA, Mordi, IR, Singh, JS, Baig, F, Choy, A-M, Mc Crimmon, RJ, Struthers, AD & Lang, CC 2017,

'Renal and Cardiovascular Effects of sodium–glucose cotransporter 2 (SGLT2) inhibition in combination with loop Diuretics in diabetic patients with Chronic Heart Failure (RECEDE-CHF): protocol for a randomised controlled double-blind cross-over trial' BMJ Open, vol. 7, no. 10, e018097, pp. 1-10.
https://doi.org/10.1136/bmjopen-2017-018097

Research output: Contribution To Journal



Singh, JSS, Burrell, LM, Cherif, M, Squire, IB, Clark, AL & Lang, CC 2017,

'Sacubitril/valsartan: beyond natriuretic peptides' Heart, vol. 103, no. 20, pp. 1569-1577.
https://doi.org/10.1136/heartjnl-2017-311295

Research output: Contribution To Journal



Taylor, R, Dalal, H, Davies, R, Doherty, P, Jolly, K, Lang, C & Wingham, J 2017,

'Cardiac rehabilitation in heart failure with reduced ejection fraction: A "should take it and not leave it" intervention' American Heart Journal, vol. 192, pp. e1-e2.
https://doi.org/10.1016/j.ahj.2017.07.007

Research output: Contribution To Journal



Zaid Iskandar, M & Lang, CC 2017,

'Sacubitril and valsartan fixed combination to reduce heart failure events in post-acute myocardial infarction patients' Drugs of Today , vol. 53, no. 10, pp. 545-551.
https://doi.org/10.1358/dot.2017.53.10.2722396

Research output: Contribution To Journal



Kang, C-K, Pope, M, Lang, C & Kalra, PR 2017,

'Iron Deficiency in Heart Failure: Efficacy and safety of intravenous iron therapy' Cardiovascular Therapeutics, vol. 35, no. 6, e12301, pp. 1-8.
https://doi.org/10.1111/1755-5922.12301

Research output: Contribution To Journal



Brown, AJM, Lang, C, Mc Crimmon, R & Struthers, A 2017,

'Does dapagliflozin regress left ventricular hypertrophy in patients with type 2 diabetes? A prospective, double-blind, randomised, placebo-controlled study' BMC Cardiovascular Disorders, vol. 17, 229, pp. 1-12.
https://doi.org/10.1186/s12872-017-0663-6

Research output: Contribution To Journal



Ouwerkerk, W, Voors, AA, Anker, SD, Cleland, JG, Dickstein, K, Filippatos, G, van der Harst, P, Hillege, HL, Lang, CC, ter Maaten, JM, Ng, LL, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zannad, F, Metra, M & Zwinderman, AH 2017,

'Determinants and clinical outcome of uptitration of ACE-inhibitor and beta-blocker in patients with heart failure: a prospective European study' European Heart Journal, vol. 38, no. 24, pp. 1883-1890b.
https://doi.org/10.1093/eurheartj/ehx026

Research output: Contribution To Journal



Rankin, S, Elder, DH, Ogston, S, George, J, Lang, CC & Choy, AM 2017,

'Population-Level Incidence and Monitoring of Adverse Drug Reactions with Long-term Amiodarone Therapy' Cardiovascular Therapeutics, vol. 35, no. 3, e12258, pp. 1-7.
https://doi.org/10.1111/1755-5922.12258

Research output: Contribution To Journal



Steggall, A, Mordi, I & Lang, C 2017,

'Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure' Diseases, vol. 5, no. 2, 14, pp. 1-18.
https://doi.org/10.3390/diseases5020014

Research output: Contribution To Journal



Voors, AA, Ouwerkerk, W, Zannad, F, van Veldhuisen, DJ, Samani, NJ, Ponikowski, P, Ng, L, Metra, M, ter Maaten, JM, Lang, C, Hillege, HL, van der Harst, P, Filippatos, GS, Dickstein, K, Cleland, JGF, Anker, SD & Zwinderman, K 2017,

'Development and validation of multivariable models to predict mortality and hospitalization in patients with heart failure' European Journal of Heart Failure, vol. 19, no. 5, pp. 627-634.
https://doi.org/10.1002/ejhf.785

Research output: Contribution To Journal



Singh, A, Greenwood, JP, Berry, C, Dawson, DK, Hogrefe, K, Kelly, DJ, Dhakshinamurthy, V, Lang, CC, Khoo, JP, Sprigings, D, Steeds, RP, Jerosch-Herold, M, Neubauer, S, Prendergast, B, Williams, B, Zhang, R, Hudson, I, Squire, IB, Ford, I, Samani, NJ & Mc Cann, GP 2017,

'Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in Aortic Stenosis (PRIMID AS) study' European Heart Journal, vol. 38, no. 16, pp. 1222-1229.
https://doi.org/10.1093/eurheartj/ehx001

Research output: Contribution To Journal



Patel, SK, Wai, B, Lang, CC, Levin, D, Palmer, CNA, Parry, HM, Velkoska, E, Harrap, SB, Srivastava, PM & Burrell, LM 2017,

'Genetic variation in Kruppel like factor 15 is associated with left ventricular hypertrophy in patients with type 2 diabetes: discovery and replication cohorts ' EBio Medicine, vol. 18, pp. 171-178.
https://doi.org/10.1016/j.ebiom.2017.03.036

Research output: Contribution To Journal



Kwiecinski, J, Chin, CWL, Everett, RJ, White, AC, Semple, SS, Yeung, E, Jenkins, WJ, Shah, ASV, Koo, M, Mirsadraee, S, Lang, CC, Mills, N, Prasad, SK, Jansen, MA, Japp, A, Newby, DE & Dweck, MR 2017,

'Adverse prognosis associated with asymmetric myocardial thickening in aortic stenosis' European Heart Journal - Cardiovascular Imaging.
https://doi.org/10.1093/ehjci/jex052

Research output: Contribution To Journal



Mahmoudpour, SH, Veluchamy, A, Siddiqui, MK, Asselbergs, FW, Souverein, PC, de Keyser, CE, Hofman, A, Lang, CC, Doney, ASF, Stricker, BH, de Boer, A, Maitland-van der Zee, A-H, Palmer, CNA & on behalf of the PREDICTION-ADR consortium 2017,

'Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors' Pharmacogenetics and Genomics, vol. 27, no. 3, pp. 112-119.
https://doi.org/10.1097/FPC.0000000000000264

Research output: Contribution To Journal



Eyre, V, Lang, CC, Smith, K, Jolly, K, Davis, R, Hayward, C, Wingham, J, Abraham, C, Green, C, Warren, FC, Britten, N, Greaves, CJ, Doherty, P, Austin, J, Van Lingen, R, Singh, S, Buckingham, S, Paul, K, Taylor, RS, Dalal, HM & on behalf of the REACH-HF investigators 2016,

'Rehabilitation Enablement in Chronic Heart Failure—a facilitated self-care rehabilitation intervention in patients with heart failure with preserved ejection fraction (REACH-HFp EF) and their caregivers: rationale and protocol for a single-centre pilot randomised controlled trial' BMJ Open, vol. 6, no. 10, e012853, pp. 1-11.
https://doi.org/10.1136/bmjopen-2016-012853

Research output: Contribution To Journal



Cameron, AR, Morrison, V, Levin, D, Mohan, M, Forteath, C, Beall, C, Mc Neilly, AD, Balfour, DJK, Savinko, T, Wong, AKF, Viollet, B, Sakamoto, K, Fagerholm, SC, Foretz, M, Lang, CC & Rena, G 2016,

'Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status' Circulation Research, vol. 119, no. 5, pp. 652-665.
https://doi.org/10.1161/CIRCRESAHA.116.308445

Research output: Contribution To Journal



Singh, JSS, Fathi, A, Vickneson, K, Mordi, I, Mohan, M, Houston, JG, Pearson, ER, Struthers, AD & Lang, CC 2016,

'Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design' Cardiovascular Diabetology, vol. 15, 97, pp. 1-11.
https://doi.org/10.1186/s12933-016-0419-0

Research output: Contribution To Journal



Voors, AA, Anker, SD, Cleland, JG, Dickstein, K, Filippatos, G, van der Harst, P, Hillege, HL, Lang, CC, ter Maaten, JM, Ng, L, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zannad, F, Zwinderman, AH & Metra, M 2016,

'A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure: Rationale, design, and baseline characteristics of BIOSTAT-CHF' European Journal of Heart Failure, vol. 18, no. 6, pp. 716-726.
https://doi.org/10.1002/ejhf.531

Research output: Contribution To Journal



Lang, CC 2016,

'Meet our editorial board member' Current Clinical Pharmacology, vol. 11, no. 2, pp. 71.
https://doi.org/10.2174/157488471102160801180437

Research output: Contribution To Journal



Lang, C 2016,

Publication process. in S Ray, S Fitzpatrick, R Gloubic & S Fisher (eds), Oxford Handbook of Clinical and Healthcare Research. Oxford Medical Handbooks, Oxford University Press, United Kingdom.

Research output: Contribution To Book Anthology



Lang, CC 2016,

'Obituary' Cardiovascular Therapeutics, vol. 34, no. 1, pp. 3.
https://doi.org/10.1111/1755-5922.12170

Research output: Contribution To Journal



Elder, DHJ, Singh, JSS, Levin, D, Donnelly, LA, Choy, A-MJ, George, J, Struthers, AD, Doney, ASF & Lang, CC 2016,

'Mean Hb A1c and mortality in diabetic individuals with heart failure: a population cohort study' European Journal of Heart Failure, vol. 18, no. 1, pp. 94-102.
https://doi.org/10.1002/ejhf.455

Research output: Contribution To Journal



Chin, CWL, Djohan, AH & Lang, CC 2016,

'The role of cardiac biochemical markers in aortic stenosis' Biomarkers, vol. 21, no. 4, pp. 316-327.
https://doi.org/10.3109/1354750X.2016.1141993

Research output: Contribution To Journal



Anwar, MS, Iskandar, MZ, Parry, HM, Doney, AS, Palmer, CN & Lang, CC 2015,

'The future of pharmacogenetics in the treatment of heart failure' Pharmacogenomics, vol. 16, no. 16, pp. 1817-1827.
https://doi.org/10.2217/pgs.15.120

Research output: Contribution To Journal



Chong, VH, Singh, J, Parry, H, Saunders, J, Chowdhury, F, Mancini, DM & Lang, CC 2015,

'Management of noncardiac comorbidities in chronic heart failure' Cardiovascular Therapeutics, vol. 33, no. 5, pp. 300-315.
https://doi.org/10.1111/1755-5922.12141

Research output: Contribution To Journal



Mohan, M, Hawkey, S, Baig, F, Choy, AM & Lang, CC 2015,

'Underutilisation of IV nitrates in the treatment of acute heart failure' Cardiovascular Therapeutics, vol. 33, no. 4, pp. 247-252.
https://doi.org/10.1111/1755-5922.12135

Research output: Contribution To Journal



Elder, DH, Mohan, M, Cochrane, L, Charles, H & Lang, CC 2015,

'Characterizing patients with chronic heart failure in community care after hospitalization: a potential role for ivabradine' Cardiovascular Therapeutics, vol. 33, no. 3, pp. 104-108.
https://doi.org/10.1111/1755-5922.12117

Research output: Contribution To Journal



Parry, HM, Desmukh, H, Levin, D, Van Zuydam, N, Elder, DHJ, Morris, AD, Struthers, AD, Palmer, CNA, Doney, ASF & Lang, CC 2015,

'Both high and low Hb A1c predict incident heart failure in type 2 diabetes mellitus' Circulation: Heart Failure, vol. 8, no. 2, pp. 236-242.
https://doi.org/10.1161/CIRCHEARTFAILURE.113.000920

Research output: Contribution To Journal



Nadir, MA, Gandy, S, Ireland, S, Mac Donald, T, Dow, E, Houston, G, Lang, C & Struthers, A 2015,

'An increased B-type natriuretic peptide in the absence of a cardiac abnormality identifies those whose left ventricular mass will increase over time' JACC: Heart Failure, vol. 3, no. 1, pp. 87-93.
https://doi.org/10.1016/j.jchf.2014.07.012

Research output: Contribution To Journal



Goudie, A, Elder, D, Deshmukh, H, Szwejkowski, BR, Lang, CC & George, J 2015,

'Effect of warfarin on survival in patients with concomitant left ventricular systolic dysfunction and pulmonary hypertension: a population cohort study' European Journal of Heart Failure, vol. 17, no. 1, pp. 90-7.
https://doi.org/10.1002/ejhf.199

Research output: Contribution To Journal



Singh, JSS & Lang, CC 2015,

'Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond' Vascular Health and Risk Management, vol. 11, pp. 283-295.
https://doi.org/10.2147/VHRM.S55630

Research output: Contribution To Journal



Singh, S, Beadle, R, Cameron, D, Rudd, A, Bruce, M, Jagpal, B, Schwarz, K, Brindley, G, Mckiddie, F, Lang, C, Dawson, D & Frenneaux, M 2014,

'Randomized double-blind placebo-controlled trial of perhexiline in heart failure with preserved ejection fraction syndrome' Future Cardiology, vol. 10, no. 6, pp. 693-698.
https://doi.org/10.2217/fca.14.62

Research output: Contribution To Journal



Chin, CWL, Shah, ASV, Mc Allister, DA, Cowell, SJ, Alam, S, Langrish, JP, Strachan, FE, Hunter, AL, Maria Choy, A, Lang, CC, Walker, S, Boon, NA, Newby, DE, Mills, NL & Dweck, MR 2014,

'High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis' European Heart Journal, vol. 35, no. 34, pp. 2312-2321.
https://doi.org/10.1093/eurheartj/ehu189

Research output: Contribution To Journal



O'Neill, L, Smith, K, Currie, PF, Elder, DHJ, Wei, L & Lang, CC 2014,

'Nurse-led Early Triage (NET) study of chest pain patients: a long term evaluation study of a service development aimed at improving the management of patients with non-ST-elevation acute coronary syndromes' European Journal of Cardiovascular Nursing, vol. 13, no. 3, pp. 253-260.
https://doi.org/10.1177/1474515113488026

Research output: Contribution To Journal



Mohan, M, Deshmukh, H, Maria Choy, A & Lang, C 2014,

'60 insulin resistance is associated with all-cause mortality and accelerates the risk of progression to diabetes in non-diabetic heart failure patients' Heart, vol. 100 , no. s3, pp. A34.
https://doi.org/10.1136/heartjnl-2014-306118.60

Research output: Contribution To Journal



Huy, TC, Quinn, PA, Sandhu, JK, Voors, AA, Parry, H, Lang, CC, Jones, DJL & Ng, LL 2014,

'Discovering new biomarkers for predicting treatment response in heart failure using plasma proteomics' Heart (British Cardiac Society), vol. 100 , no. Suppl 3, pp. A30.
https://doi.org/10.1136/heartjnl-2014-306118.52

Research output: Contribution To Journal



George, J, Struthers, AD & Lang, CC 2014,

'Modulation of the Renin-Angiotensin-aldosterone system in heart failure' Current Atherosclerosis Reports, vol. 16, no. 4, pp. 403.
https://doi.org/10.1007/s11883-014-0403-7

Research output: Contribution To Journal



Zachariah, D, Brown, R, Kanagala, P, Bashir, A, Mohan, M, Callan, P, Rajendra, R, Clark, AL, Squire, I, Gunning, M, Lang, CC & Kalra, PR 2014,

'The impact of age and chronic kidney disease on secondary prevention post-primary percutaneous coronary intervention' QJM : an International Journal of Medicine, vol. 107, no. 3, pp. 185-192.
https://doi.org/10.1093/qjmed/hct222

Research output: Contribution To Journal



Nadir, MA, Dow, E, Davidson, J, Kennedy, N, Lang, CC & Struthers, AD 2014,

'Myocardial ischaemia is associated with an elevated brain natriuretic pepide level even in the presence of left ventricular systolic dysfunction' European Journal of Heart Failure, vol. 16, no. 1, pp. 56-67.
https://doi.org/10.1093/eurjhf/hft130

Research output: Contribution To Journal



Pauriah, M, Elder, DHJ, Ogston, S, Noman, AYS, Majeed, A, Wyatt, JC, Choy, A-M, Mac Donald, TM, Struthers, AD & Lang, CC 2014,

'High-potency statin and ezetimibe use and mortality in survivors of an acute myocardial infarction: a population-based study' Heart, vol. 100, no. 11, pp. 867-872.
https://doi.org/10.1136/heartjnl-2013-304678

Research output: Contribution To Journal



Valluri, A, Struthers, AD & Lang, CC 2013,

'Novel Blockers of the Renin-Angiotensin-Aldosterone System in Chronic Heart Failure' Current Heart Failure Reports.
https://doi.org/10.1007/s11897-013-0173-5

Research output: Contribution To Journal



Shearer, F, Lang, CC & Struthers, AD 2013,

'Renin-Angiotensin-aldosterone system inhibitors in heart failure' Clinical Pharmacology & Therapeutics, vol. 94, no. 4, pp. 459-467.
https://doi.org/10.1038/clpt.2013.135

Research output: Contribution To Journal



Witham, MD, Dove, FJ, Khan, F, Lang, CC, Belch, JJF & Struthers, AD 2013,

'Effects of Vitamin D supplementation on markers of vascular function after myocardial infarction: A randomised controlled trial' International journal of cardiology, vol. 167, no. 3, pp. 745-749.
https://doi.org/10.1016/j.ijcard.2012.03.054

Research output: Contribution To Journal



Parry, HM, Donnelly, LA, Van Zuydam, N, Doney, ASF, Elder, DHJ, Morris, AD, Struthers, AD, Palmer, CNA, Lang, CC & Wellcome Trust Case Control Consortium 2 2013,

'Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis' Cardiovascular Diabetology, vol. 12, 109.
https://doi.org/10.1186/1475-2840-12-109

Research output: Contribution To Journal



Rekhraj, S, Gandy, SJ, Szwejkowski, BR, Nadir, MA, Noman, A, Houston, G, Lang, CC, George, J & Struthers, AD 2013,

'High-Dose Allopurinol reduces left ventricular mass in patients with ischemic heart disease' Journal of the American College of Cardiology, vol. 61, no. 9, pp. 926-32.
https://doi.org/10.1016/j.jacc.2012.09.066

Research output: Contribution To Journal



Lang, CC & Struthers, AD 2013,

'Targeting the renin-angiotensin-aldosterone system in heart failure' Nature reviews. Cardiology, vol. 10, pp. 125-134.
https://doi.org/10.1038/nrcardio.2012.196

Research output: Contribution To Journal



Vella, S, Donnelly, L, Lang, CC, Pearson, ER & Petrie, JR 2013,

'Is thiazolidinedione treatment an important cause of oedema?' Diabetic Medicine, vol. 30, no. Suppl. 1, P562, pp. 197-197.
https://doi.org/10.1111/dme.12091_2

Research output: Contribution To Journal



Elder, DHJ, Mc Alpine-Scott, V, Choy, AM, Struthers, AD & Lang, CC 2013,

'Aortic valvular heart disease: is there a place for angiotensin-converting-enzyme inhibitors?' Expert Review of Cardiovascular Therapy, vol. 11, no. 1, pp. 107-14.
https://doi.org/10.1586/erc.12.143

Research output: Contribution To Journal



Krum, H & Lang, C 2013,

'Mind your language: conveying the results of clinical trials of cardiovascular therapies' Cardiovascular Therapeutics, vol. 31, no. 1, pp. 1.
https://doi.org/10.1111/j.1755-5922.2012.00316.x

Research output: Contribution To Journal



Vella, S, Donnelly, L, Lang, CC, Pearson, ER & Petrie, JR 2013,

'Is thiazolidinedione treatment an important cause of oedema?' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Research output: Contribution To Conference



Parry, H, Donnelly, L, Van Zuydam, N, Morris, A, Elder, DH, Doney, ASF, Palmer, CNA & Lang, CC 2013,

'Glycaemic control and the development of heart failure' Journal of the American College of Cardiology, vol. 61, no. 10 Supplement, pp. E566.
https://doi.org/10.1016/S0735-1097(13)60566-5

Research output: Contribution To Journal



Parry, H, Donnelly, L, Van Zuydam, N, Doney, A, Elder, D, Morris, A, Struthers, AD, Palmer, C & Lang, C 2013,

'Genetic variants predicting left ventricular hypertrophy in a diabetic population' Journal of the American College of Cardiology, vol. 61, no. 10 Supplement, pp. E598.
https://doi.org/10.1016/S0735-1097(13)60598-7

Research output: Contribution To Journal



Szwejkowski, BR, Gandy, S, Rekhraj, S, Houston, G, George, J, Lang, CC, Morris, AD & Struthers, AD 2013,

'Allopurinol reduces left ventricular mass in patients with type ii diabetes and left ventricular hypertrophy' Journal of the American College of Cardiology, vol. 61, no. 10 Supplement, pp. E1256.
https://doi.org/10.1016/S0735-1097(13)61256-5

Research output: Contribution To Journal



Parry, HM, Doney, A, Palmer, CNA & Lang, CC 2013,

'State of play of pharmacogenetics and personalized medicine in heart failure' Cardiovascular Therapeutics, vol. 31, no. 6, pp. 315-322.
https://doi.org/10.1111/1755-5922.12030

Research output: Contribution To Journal



Wong, AKF, Symon, R, Alzadjali, MA, Ang, DSC, Ogston, S, Choy, AM, Petrie, JR, Struthers, AD & Lang, CC 2012,

'The effect of metformin on insulin resistance and exercise parameters in patients with heart failure' European Journal of Heart Failure, vol. 14, no. 11, pp. 1303-1310.
https://doi.org/10.1093/eurjhf/hfs106

Research output: Contribution To Journal



Nadir, MA, Rekhraj, S, Wei, L, Lim, TK, Davidson, J, Mac Donald, TM, Lang, CC, Dow, E & Struthers, AD 2012,

'Improving the primary prevention of cardiovascular events by using biomarkers to identify individuals with silent heart disease' Journal of the American College of Cardiology, vol. 60, no. 11, pp. 960-968.
https://doi.org/10.1016/j.jacc.2012.04.049

Research output: Contribution To Journal



Rekhraj, S, Szwejkowski, B, Nadir, A, Gandy, S, George, J, Lang, CC & Struthers, AD 2012,

'High dose allopurinol reduces left ventricular hypertrophy and improves endothelial function in patients with chronic stable angina' European Heart Journal, vol. 33, no. S1, pp. 350-350.
https://doi.org/10.1093/eurheartj/ehs282

Research output: Contribution To Journal



Elder, DHJ, Lang, CC, Rekhraj, S, Szwejkowski, B, George, J, Pringle, SD, Struthers, AD & Choy, AM 2012,

'Renin-angiotensin system blockers are associated with reduced mortality and heart failure hospitalization in patients paced for complete atrioventricular block' Heart Rhythm : the Official Journal of the Heart Rhythm Society, vol. 9, no. 4, pp. 505-510.
https://doi.org/10.1016/j.hrthm.2011.11.021

Research output: Contribution To Journal



George, J, Jack, D, Mackle, G, Callaghan, TS, Wei, L, Lang, CC, Dow, E & Struthers, AD 2012,

'High sensitivity troponin T provides useful prognostic information in non-acute chest pain' QJM : an International Journal of Medicine, vol. 105, no. 2, pp. 159-166.
https://doi.org/10.1093/qjmed/hcr174

Research output: Contribution To Journal



Witham, MD, Dove, FJ, Khan, F, Lang, CC, Belch, JJF & Struthers, AD 2012,

'Does vitamin D supplementation improve markers of vascular health in post myocardial infarction patients? a randomised controlled trial' Age and Ageing, vol. 41, no. Supplement 1, pp. i10-i10.
https://doi.org/10.1093/ageing/afr168

Research output: Contribution To Journal



Szwejkowski, BR, Elder, DHJ, Shearer, F, Jack, D, Choy, AMJ, Pringle, SD, Struthers, AD, George, J & Lang, CC 2012,

'Pulmonary hypertension predicts all-cause mortality in patients with heart failure: a retrospective cohort study' European Journal of Heart Failure, vol. 14, no. 2, pp. 162-167.
https://doi.org/10.1093/eurjhf/hfr159

Research output: Contribution To Journal



Newton, DJ, Kennedy, G, Chan, KKF, Lang, CC, Belch, JJF & Khan, F 2012,

'Large and small artery endothelial dysfunction in chronic fatigue syndrome' International journal of cardiology, vol. 154, no. 3, pp. 335-336.
https://doi.org/10.1016/j.ijcard.2011.10.030

Research output: Contribution To Journal



Witham, MD, Fulton, RL, Greig, CA, Johnston, DW, Lang, CC, van der Pol, M, Boyers, D, Struthers, AD & Mc Murdo, MET 2012,

'Efficacy and cost of an exercise program for functionally impaired older patients with heart failure: a randomized controlled trial' Circulation: Heart Failure, vol. 5, no. 2, pp. 209-216.
https://doi.org/10.1161/CIRCHEARTFAILURE.111.963132

Research output: Contribution To Journal



Ang, DSC, Kao, MPC, Noman, A, Lang, CC & Struthers, AD 2012,

'The prognostic significance of early and late anaemia in acute coronary syndrome' QJM : an International Journal of Medicine, vol. 105, no. 5, pp. 445-454.
https://doi.org/10.1093/qjmed/hcr258

Research output: Contribution To Journal



Ang, DSC, Kao, MPC, Dow, E, Lang, C & Struthers, A 2012,

'The prognostic value of a 7-week high sensitivity troponin T level after an acute coronary syndrome' Heart, vol. 98, no. 15, pp. 1160-5.
https://doi.org/10.1136/heartjnl-2012-301635

Research output: Contribution To Journal



Pauriah, M, Khan, F, Lim, TK, Elder, DH, Godfrey, V, Kennedy, G, Belch, JJF, Booth, NA, Struthers, AD & Lang, CC 2012,

'B-type natriuretic peptide is an independent predictor of endothelial function in man' Clinical Science, vol. 123, no. 5, pp. 307-312.
https://doi.org/10.1042/CS20110168

Research output: Contribution To Journal



Elder, DHJ, Shearer, F, Dawson, A, Pradeep, M, Parry, H, Currie, P, Pringle, SD, George, J, Choy, A & Lang, CC 2012,

'Automated data capture from echocardiography reports to enhance hart failure population research' Heart, vol. 98, no. Suppl. 1, pp. A10-A10.
https://doi.org/10.1136/heartjnl-2012-301877b.12

Research output: Contribution To Journal



Elder, DHJ, Donnelly, L, Wong, A, Szwejkowski, BR, Pauriah, M, Lim, TK, Pringle, SD, Choy, A, Pearson, E, Morris, A, George, J, Struthers, A, Palmer, C, Doney, A & Lang, C 2012,

'HBA1C and mortality in diabetic individuals with heart failure: an observational cohort study' Heart, vol. 98, no. Suppl. 1, pp. A9-A10.
https://doi.org/10.1136/heartjnl-2012-301877b.11

Research output: Contribution To Journal



Kalra, PR, Morley, C, Barnes, S, Menown, I, Kassianos, G, Padmanabhan, S, Gupta, S & Lang, CC 2012,

'Discontinuation of beta-blockers in cardiovascular disease: UK primary care cohort study' International journal of cardiology, vol. 167, no. 6, pp. 2695-2699.
https://doi.org/10.1016/j.ijcard.2012.06.116

Research output: Contribution To Journal



Wong, AKF, Struthers, AD, Choy, AMJ & Lang, CC 2012,

'Insulin sensitization therapy and the heart: focus on metformin and thiazolidinediones' Heart Failure Clinics, vol. 8, no. 4, pp. 539-50.
https://doi.org/10.1016/j.hfc.2012.06.002

Research output: Contribution To Journal



Menown, IBA, Davies, S, Gupta, S, Kalra, PR, Lang, CC, Morley, C & Padmanabhan, S 2012,

'Resting heart rate and outcomes in patients with cardiovascular disease: where do we currently stand?' Cardiovascular Therapeutics, vol. 31, no. 4, pp. 215-223.
https://doi.org/10.1111/j.1755-5922.2012.00321.x

Research output: Contribution To Journal



Nadir, MA, Dow, E, Lang, CC, Davidson, J, Mac Donald, T & Struthers, AD 2011,

'High Sensitivity Cardiac Troponin T is Associated with Silent Cardiac Target Organ Damage in Asymptomatic Primary Prevention Patients' Circulation, vol. 124, no. 21, pp. -.

Research output: Contribution To Journal



Goudie, A, Elder, D, Robertson, A, Struthers, AD, Lang, C & Szwejkowski, B 2011,

'Warfarin Use is Associated With Reduced Mortality in Patients with Left Ventricular Systolic Dysfunction and Pulmonary Hypertension Ventricular Systolic Dysfunction and Pulmonary Hypertension' Circulation, vol. 124, no. 21, pp. -.

Research output: Contribution To Journal



Elder, DHJ, Wei, L, Szwejkowski, BR, Libianto, R, Nadir, A, Pauriah, M, Rekhraj, S, Lim, TK, George, J, Doney, A, Pringle, SD, Choy, A-M, Struthers, AD & Lang, CC 2011,

'The impact of renin-angiotensin-aldosterone system blockade on heart failure outcomes and mortality in patients identified to have aortic regurgitation: a large population cohort study' Journal of the American College of Cardiology, vol. 58, no. 20, pp. 2084-2091.
https://doi.org/10.1016/j.jacc.2011.07.043

Research output: Contribution To Journal



View full profile on research portal

Activities

Exercise intolerance in heart failure’ 2nd Asian Pacific Congress of Heart Failure, Singapore

Role: Speaker
Activity: Lecture

 3 2005

Diabetes UK Professional Conference 2013

Role: Participant
Activity: Participation in conference

13 3 2013

98th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics

Role: Participant
Activity: Participation in conference

5 3 1997