Charlotte Proby

+44 (0)1382 383289
Professor of Dermatology

Publications

Inman, GJ, Wang, J, Nagano, A, Alexandrov, LB, Purdie, KJ, Taylor, RG, Sherwood, V, Thomson, J, Hogan, S, Spender, LC, South, AP, Stratton, M, Chelala, C, Harwood, CA, Proby, CM & Leigh, IM 2018,

'The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature' Nature Communications, vol. 9, no. 1, 3667. DOI:
10.1038/s41467-018-06027-1

Research output: Contribution To Journal



Affleck, AG & Proby, CM 2018,

'Completion lymphadenectomy should not necessarily be recommended after a positive sentinel lymph node biopsy' Clinical and experimental dermatology. DOI:
10.1111/ced.13725

Research output: Contribution To Journal



Purdie, KJ, Proby, CM, Rizvi, H, Griffin, H, Doorbar, J, Sommerlad, M, Feltkamp, MC, Van der Meijden, E, Inman, GJ, South, AP, Leigh, IM & Harwood, CA 2018,

'The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions' Frontiers in Microbiology, vol. 9, 1806. DOI:
10.3389/fmicb.2018.01806

Research output: Contribution To Journal



Crawford, G, Hayes, MD, Seoane, RC, Ward, S, Dalessandri, T, Lai, C, Healy, E, Kipling, D, Proby, C, Moyes, C, Green, K, Best, K, Haniffa, M, Botto, M, Dunn-Walters, D & Strid, J 2018,

'Epithelial damage and tissue γδ T cells promote a unique tumor-protective Ig E response' Nature Immunology, vol. 19, no. 8, pp. 859-870. DOI:
10.1038/s41590-018-0161-8

Research output: Contribution To Journal



Keohane, SG, Proby, CM, Newlands, C, Motley, RJ, Nasr, I, Mohd Mustapa, MF & Slater, DN 2018,

'The new 8th edition of TNM staging and its implications for skin cancer: a review by the British Association of Dermatologists and the Royal College of Pathologists, United Kingdom' British Journal of Dermatology. DOI:
10.1111/bjd.16892

Research output: Contribution To Journal



Kopasker, D, Kwiatkowski, A, Martin, RN, Harwood, CA, Ismail, F, Lear, JT, Thomson, J, Hasan, Z, Wali, GN, Milligan, A, Crawford, L, Ahmed, I, Duffy, H, Proby, C & Allanson, P 2018,

'Patient preferences for topical treatment of actinic keratoses: a discrete-choice experiment' British Journal of Dermatology. DOI:
10.1111/bjd.16801

Research output: Contribution To Journal



Harkins, C, Mc Aleer, MA, Bennett, D, Mc Hugh, M, Fleury, OM, Pettigrew, KA, Oravcová, K, Parkhill, J, Proby, C, Dawe, R, Geoghegan, JA, Irvine, AD & Holden, MTG 2018,

'The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from Atopic Dermatitis patients' British Journal of Dermatology. DOI:
10.1111/bjd.16722

Research output: Contribution To Journal



Hepburn, L, Mc Hugh, A, Fernandes, K, Boag, G, Proby, C, Leigh, I & Saville, M 2018,

'Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity' Oncotarget, vol. 9, no. 33, pp. 23029-23046. DOI:
10.18632/oncotarget.25196

Research output: Contribution To Journal



Toutfaire, M, Dumortier, E, Fattaccioli, A, Van Steenbrugge, M, Proby, CM & Debacq-Chainiaux, F 2018,

'Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis' International Journal of Biochemistry and Cell Biology, vol. 98, pp. 113-126. DOI:
10.1016/j.biocel.2018.03.005

Research output: Contribution To Journal



Mc Hugh, A, Fernandes, K, South, A, Mellerio, JE, Salas-Alanis, JC, Proby, C, Leigh, I & Saville, M 2018,

'Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity' Oncotarget, vol. 9, pp. 20265-20281. DOI:
10.18632/oncotarget.24750

Research output: Contribution To Journal



Rose, AM, Spender, LC, Stephen, C, Mitchell, A, Rickaby, W, Bray, S, Evans, AT, Dayal, J, Purdie, KJ, Harwood, CA, Proby, CM, Leigh, IM, Coates, PJ & Inman, GJ 2018,

'Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma' Oncotarget, vol. 9, no. 18, pp. 14552-14566. DOI:
10.18632/oncotarget.24545

Research output: Contribution To Journal



Harkins, C, Pettigrew, KA, Oravcová, K, Gardner, J, Hearn, RMR, Rice, D, Mather, AE, Parkhill, J, Brown, S, Proby, C & Holden, MTG 2018,

'The micro-evolution and epidemiology of Staphylococcus aureus colonization during atopic eczema disease flare' Journal of Investigative Dermatology, vol. 138, no. 2, pp. 336-343. DOI:
10.1016/j.jid.2017.09.023

Research output: Contribution To Journal



Kalin, JH, Wu, M, Gomez, AV, Song, Y, Das, J, Hayward, D, Adejola, N, Wu, M, Panova, I, Chung, HJ, Kim, E, Roberts, HJ, Roberts, JM, Prusevich, P, Jeliazkov, JR, Burman, SSR, Fairall, L, Milano, C, Eroglu, A, Proby, C, Dinkova-Kostova, A, Hancock, WW, Gray, JJ, Bradner, JE, Valente, S, Mai, A, Anders, NM, Rudek, MA, Hu, Y, Ryu, B, Schwabe, JWR, Mattevi, A, Alani, RM & Cole, PA 2018,

'Targeting the Co REST complex with dual histone deacetylase and demethylase inhibitors' Nature Communications, vol. 9, no. 1, 53, pp. 1-13. DOI:
10.1038/s41467-017-02242-4

Research output: Contribution To Journal



Bouwes Bavinck, JN, Feltkamp, MCW, Green, AC, Fiocco, M, Euvrard, S, Harwood, CA, Proby, CM, Naldi, L, Diphoorn, JCD, Venturuzzo, A, Tessari, G, Nindl, I, Sampogna, F, Abeni, D, Neale, RE, Goeman, JJ, Quint, KD, Halk, AB, Sneek, C, Genders, RE, de Koning, MNC, Quint, WGV, Wieland, U, Weissenborn, S, Waterboer, T, Pawlita, M, Pfister, HJ & The EPI-HPV-UV-CA group 2017,

'Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study' American Journal of Transplantation. DOI:
10.1111/ajt.14537

Research output: Contribution To Journal



Lai, K, Harwood, CA, Purdie, KJ, Proby, CM, Leigh, IM, Ravi, N, Mully, TW, Brooks, L, Sandoval, PM, Rosenblum, MD & Arron, ST 2017,

'Genomic analysis of atypical fibroxanthoma' PLo S ONE, vol. 12, no. 11, e0188272, pp. 1-15. DOI:
10.1371/journal.pone.0188272

Research output: Contribution To Journal



Harwood, CA, Toland, AE, Proby, CM, Euvrard, S, Hofbauer, GFL, Tommasino, M, Bouwes-Bavinck, JN & Kera Con Consortium 2017,

'The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients' British Journal of Dermatology, vol. 177, no. 5, pp. 1217-1224. DOI:
10.1111/bjd.15956

Research output: Contribution To Journal



Rose, AM, Nicoll, KJ, Moinie, A, Jordan, DJ, Evans, AT, Proby, CM & Naasan, A 2017,

'Patients with low-risk cutaneous squamous cell carcinoma do not require extended out-patient follow-up' Journal of Plastic, Reconstructive and Aesthetic Surgery, vol. 70, no. 6, pp. 852-855. DOI:
10.1016/j.bjps.2017.03.006

Research output: Contribution To Journal



Oh, CC, Hofbauer, GFL, Serra, AL, Harwood, CA, Mitchell, L, Proby, CM, Olasz, EB, Mosel, DD, Piaserico, S, Fortina, AB, Geusau, A, Jahn-Bassler, K, Gerritsen, MJP, Seçkin, D, Güleç, AT, Cetkovská, P, Ricar, J, Imko-Walczuk, B, Dębska-Ślizień, A & Bouwes Bavinck, JN 2017,

'Painful skin lesions and squamous cell carcinoma predict overall mortality risk in organ transplant recipients: a cohort study' British Journal of Dermatology, vol. 176, no. 5, pp. 1179-1186. DOI:
10.1111/bjd.15269

Research output: Contribution To Journal



Marsden, J, Fox, R, Boota, NM, Cook, M, Wheatley, K, Billingham, LJ, Steven, NM, NCRI Skin Cancer Clinical Studies Group, U.K. Dermatology Clinical Trials Network & LIMIT-1 Collaborative Group 2017,

'Effect of topical imiquimod as primary treatment for lentigo maligna: the LIMIT-1 study' British Journal of Dermatology, vol. 176, no. 5, pp. 1148-1154. DOI:
10.1111/bjd.15112

Research output: Contribution To Journal



Knatko, EV, Praslicka, B, Higgins, M, Evans, A, Purdie, KJ, Harwood, CA, Proby, CM, Ooi, A & Dinkova-Kostova, AT 2017,

'Whole-exome sequencing validates a preclinical mouse model for the prevention and treatment of cutaneous squamous cell carcinoma' Cancer Prevention Research, vol. 10, no. 1, pp. 67-75. DOI:
10.1158/1940-6207.CAPR-16-0218

Research output: Contribution To Journal



Adelmann, CH, Truong, KA, Liang, RJ, Bansal, V, Gandee, L, Saporito, R, Lee, W, Du, L, Nicholas, C, Napoli, M, Mino, B, South, AP, Proby, CM, Leigh, IM, Coarfa, C, Flores, ER & Tsai, KY 2016,

'MEK is a therapeutic and chemopreventative target in squamous cell carcinoma' Journal of Investigative Dermatology, vol. 136, no. 9, pp. 1920-1924. DOI:
10.1016/j.jid.2016.05.110

Research output: Contribution To Journal



Cammareri, P, Rose, A, Vincent, DF, Wang, J, Nagano, A, Libertini, S, Ridgway, RA, Athineos, D, Coates, PJ, Mc Hugh, A, Pourreyron, C, Dayal, J, Larsson, J, Weidlich, S, Spender, L, Sapkota, G, Purdie, KJ, Proby, C, Harwood, CA, Leigh, I, Clevers, H, Barker, N, Karlsson, S, Pritchard, C, Marais, R, Chelala, C, South, A, Sansom, OJ & Inman, G 2016,

'Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma' Nature Communications, vol. 7, 12493, pp. 1-7. DOI:
10.1038/ncomms12493

Research output: Contribution To Journal



Watt, SA, Purdie, KJ, den Breems, NY, Dimon, M, Tucker, S, Arron, ST, Mchugh, A, Xue, DJ, Dayal, JHS, Harwood, CA, Leigh, IM, Proby, CM & South, AP 2016,

'CREBBP mutation in human cutaneous squamous cell carcinoma' Experimental Dermatology, vol. 25, no. 8, pp. 650-651. DOI:
10.1111/exd.13044

Research output: Contribution To Journal



Knight, SR, Proby, C, Ziyaie, D, Carey, F & Koch, S 2016,

'Extramammary Paget disease of the perianal region: the potential role of imiquimod in achieving disease control' Journal of Surgical Case Reports, vol. 2016, no. 8, pp. 1-3. DOI:
10.1093/jscr/rjw110

Research output: Contribution To Journal



Benedict, AL, Knatko, EV, Kostov, RV, Zhang, Y, Higgins, M, Kalra, S, Fahey, JW, Ibbotson, SH, Proby, CM, Talalay, P & Dinkova-Kostova, AT 2016,

The multifaceted role of sulforaphane in protection against uv radiation-mediated skin damage. in Broccoli: Cultivation, Nutritional Properties and Effects on Health. Nova Science Publishers, pp. 185-208.

Research output: Contribution To Book Anthology



Watt, SA, Purdie, KJ, den Breems, NY, Dimon, M, Arron, ST, Mc Hugh, AT, Xue, DJ, Dayal, JHS, Proby, CM, Harwood, CA, Leigh, IM & South, AP 2015,

'Novel CARD11 mutations in human cutaneous squamous cell carcinoma lead to aberrant NF-κB regulation' American Journal of Pathology, vol. 185, no. 9, pp. 2354-2363. DOI:
10.1016/j.ajpath.2015.05.018

Research output: Contribution To Journal



Knatko, EV, Ibbotson, SH, Zhang, Y, Higgins, M, Fahey, JW, Talalay, P, Dawe, RS, Ferguson, J, Huang, JT-J, Clarke, R, Zheng, S, Saito, A, Kalra, S, Benedict, AL, Honda, T, Proby, CM & Dinkova-Kostova, AT 2015,

'Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans' Cancer Prevention Research, vol. 8, no. 6, pp. 475-486. DOI:
10.1158/1940-6207.CAPR-14-0362

Research output: Contribution To Journal



Olasz, EB, Seline, LN, Schock, AM, Duncan, NE, Lopez, A, Lazar, J, Flister, MJ, Lu, Y, Liu, P, Sokumbi, O, Harwood, CA, Proby, CM, Neuburg, M & Lazarova, Z 2015,

'Micro RNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma' PLo S ONE, vol. 10, no. 5, e0125412, pp. 1-16. DOI:
10.1371/journal.pone.0125412

Research output: Contribution To Journal



Schoenherr, C, Serrels, B, Proby, C, Cunningham, DL, Findlay, JE, Baillie, GS, Heath, JK & Frame, MC 2014,

'Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells' Journal of Cell Science, vol. 127, no. 24, pp. 5303-5316. DOI:
10.1242/jcs.157560

Research output: Contribution To Journal



South, AP, Purdie, KJ, Watt, SA, Haldenby, S, den Breems, N, Dimon, M, Arron, ST, Kluk, MJ, Aster, JC, Mc Hugh, A, Xue, DJ, Dayal, JHS, Robinson, KS, Rizvi, SMH, Proby, CM, Harwood, CA & Leigh, IM 2014,

'NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis' Journal of Investigative Dermatology, vol. 134, no. 10, pp. 2630-2638. DOI:
10.1038/jid.2014.154

Research output: Contribution To Journal



Bouwes Bavinck, JN, Harwood, CA, Genders, RE, Wisgerhof, HC, Plasmeijer, EI, Mitchell, L, Olasz, EB, Mosel, DD, Pokorney, MS, Serra, AL, Feldmeyer, L, Baumann Conzett, K, Piaserico, S, Belloni Fortina, A, Jahn, K, Geusau, A, Gerritsen, MJP, Seçkin, D, Güleç, AT, Cetkovská, P, Ricar, J, Imko-Walczuk, B, Proby, CM & Hofbauer, GFL 2014,

'Pain identifies squamous cell carcinoma in organ transplant recipients: The SCOPE-ITSCC PAIN study' American Journal of Transplantation, vol. 14, no. 3, pp. 668-676. DOI:
10.1111/ajt.12587

Research output: Contribution To Journal



Wallingford, S, Proby, CM, Vail, A, Russell, S, Lear, JT & Green, A 2013,

'Prevalence and associated risk factors for actinic keratoses and actinic field change among renal transplant patients' British Journal of Dermatology, vol. 169, no. Suppl. 1, BI04, pp. 100-101. DOI:
10.1111/bjd.12358

Research output: Contribution To Journal



Matin, RN, Gaunt, P, Mc Cartney, DL, Ismail, F, Bowden, SJ, Mc Gregor, JM, Lear, JT, Proby, CM & Harwood, CA 2013,

'Developing a standardized actinic keratosis assessment protocol' British Journal of Dermatology, vol. 169, no. Suppl. 1, BI05, pp. 101. DOI:
10.1111/bjd.12358

Research output: Contribution To Journal



Mitchell, L, Gulati, A, Mc Gregor, JM, Proby, CM & Harwood, CA 2013,

'Impact of skin cancers and premalignancies on the quality of life of organ transplant recipients' British Journal of Dermatology, vol. 169, no. Suppl. 1, BI06, pp. 101-102. DOI:
10.1111/bjd.12358

Research output: Contribution To Journal



Mitchell, L, Gulati, A, Mc Gregor, JM, Proby, CM & Harwood, CA 2013,

'Evaluation of a nurse-led clinic for skin cancer awareness and surveillance of organ transplant recipients' British Journal of Dermatology, vol. 169, no. Suppl. 1, BI14, pp. 105. DOI:
10.1111/bjd.12358

Research output: Contribution To Journal



Nigro, CL, Wang, H, Mc Hugh, A, Lattanzio, L, Matin, R, Harwood, C, Syed, N, Hatzimichael, E, Briasoulis, E, Merlano, M, Evans, A, Thompson, A, Leigh, I, Fleming, C, Inman, GJ, Proby, C & Crook, T 2013,

'Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma' Journal of Investigative Dermatology, vol. 133, no. 5, pp. 1278-1285. DOI:
10.1038/jid.2012.493

Research output: Contribution To Journal



Lambert, SR, Mladkova, N, Gulati, A, Hamoudi, R, Purdie, K, Cerio, R, Leigh, I, Proby, C & Harwood, CA 2013,

'Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling' British Journal of Cancer, vol. 110, no. 2, pp. 520-529. DOI:
10.1038/bjc.2013.760

Research output: Contribution To Journal



Harwood, CA, Mesher, D, Mc Gregor, JM, Mitchell, L, Leedham-Green, M, Raftery, M, Cerio, R, Leigh, IM, Sasieni, P & Proby, CM 2013,

'A surveillance model for skin cancer in organ transplant recipients: A 22-year prospective study in an ethnically diverse population' American Journal of Transplantation, vol. 13, no. 1, pp. 119-129. DOI:
10.1111/j.1600-6143.2012.04292.x

Research output: Contribution To Journal



Harkins, C, Watt, SA, Pourreyron, C, Leigh, IM, Proby, CM & South, AP 2013,

'Immunohistochemical assessment of MRG-binding protein and polo-like kinase 1 over-expression in human cutaneous SCC' Journal of Investigative Dermatology, vol. 133, no. S1, 414, pp. S70. DOI:
10.1038/jid.2013.96

Research output: Contribution To Journal



Lambert, SR, Mladkova, N, Gulati, A, Hamoudi, R, Purdie, KJ, Cerio, R, Leigh, IM, Proby, CM & Harwood, CA 2013,

'Expression microarray analysis identifies key processes in the transition from actinic keratosis to cutaneous squamous cell carcinoma' Journal of Investigative Dermatology, vol. 133, no. S1, 393, pp. S67. DOI:
10.1038/jid.2013.96

Research output: Contribution To Journal



Mc Hugh, AT, Purdie, K, Pourreyron, C, Watt, S, Rose, A, Leigh, I, Harwood, C, South, A & Proby, C 2013,

'Cutaneous SCC and the RAS controversy' Journal of Investigative Dermatology, vol. 133, no. S1, 386, pp. S66. DOI:
10.1038/jid.2013.96

Research output: Contribution To Journal



Pourreyron, C, Pautu, V, Simons, MR, Proby, CM, Leigh, IM & South, AP 2013,

'MMP1, 2 and 7 but not 9 or 13 promote cutaneous SCC keratinocyte invasion and migration' Journal of Investigative Dermatology, vol. 133, no. S1, 917, pp. S156. DOI:
10.1038/jid.2013.101

Research output: Contribution To Journal



Purdie, K, South, A, Sommerlad, M, Leigh, I, Proby, C & Harwood, C 2013,

'The development of cutaneous squamous lesions in patients treated with vemurafenib: a possible role for human papillomavirus in addition to activated RAS' Journal of Investigative Dermatology, vol. 133, no. S1, 357, pp. S61. DOI:
10.1038/jid.2013.96

Research output: Contribution To Journal



South, AP, Watt, SA, Purdie, KJ, Proby, CM, Harwood, CA & Leigh, IM 2013,

'Cutaneous squamous cell carcinoma carries the highest burden of mutation of any human tumor type and harbors prevalent mutations in CARD11 and CREBBP' Journal of Investigative Dermatology, vol. 133, no. S1, 427, pp. S72. DOI:
10.1038/jid.2013.96

Research output: Contribution To Journal



Wang, H, Mc Hugh, A, Matin, R, Fleming, C, Leigh, I, Harwood, C, Inman, G, Crook, T & Proby, C 2013,

'A two gene serum epigenetic signature detects metastatic melanoma with high sensitivity and specificity' Journal of Investigative Dermatology, vol. 133, no. S1, 1379, pp. S235. DOI:
10.1038/jid.2013.105

Research output: Contribution To Journal



South, AP, Purdie, KJ, Watt, SA, Harwood, CA, Proby, C & Leigh, IM 2012,

'Exome level sequencing identifies candidate genes mutated in cutaneous squamous cell carcinoma progression' Journal of Investigative Dermatology, vol. 132, pp. S37-S37.

Research output: Contribution To Journal



Traianou, A, Ulrich, M, Apalla, Z, De Vries, E, Bakirtzi, K, Kalabalikis, D, Ferrandiz, L, Ruiz-de-Casas, A, Moreno-Ramirez, D, Sotiriadis, D, Ioannides, D, Aquilina, S, Apap, C, Micallef, R, Scerri, L, Pitkanen, S, Saksela, O, Altsitsiadis, E, Hinrichs, B, Magnoni, C, Fiorentini, C, Majewski, S, Ranki, A, Proby, CM, Stockfleth, E, Trakatelli, M & EPIDERM Grp 2012,

'Risk factors for actinic keratosis in eight European centres: a case-control study' British Journal of Dermatology, vol. 167, pp. 36-42. DOI:
10.1111/j.1365-2133.2012.11085.x

Research output: Contribution To Journal



Wang, NJ, Sanborn, Z, Arnett, KL, Bayston, LJ, Liao, W, Proby, CM, Leigh, IM, Gordon, PB, Sharma, M, North, JP, Vemula, SS, Mauro, TM, Neuhaus, IM, Le Boit, PE, Kwok, P, Arron, ST, Bale, AE, Haussler, D, Cleaver, JE, Gray, JW, Spellman, PT, South, AP, Aster, JC, Blacklow, SC & Cho, RJ 2012,

'Next-generation sequencing identifies Notch receptors as integral tumor suppressors in cutaneous and lung squamous cell carcinomas' Journal of Investigative Dermatology, vol. 132, pp. S23-S23. DOI:
10.1038/jid.2012.80

Research output: Contribution To Journal



Hack, K, Reilly, L, Proby, C, Fleming, C, Leigh, I & Foerster, J 2012,

'Wnt5a inhibits the Cp G oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells' British Journal of Dermatology, vol. 166, no. 4, P-24, pp. e36-e36. DOI:
10.1111/j.1365-2133.2012.10903.x

Research output: Contribution To Journal



Mladkova, N, Mc Hugh, A, Rakyan, V, Proby, C & Harwood, C 2012,

'Methylation profiling of cutaneous squamous cell carcinoma reveals an embryonic stem cell signature among differentially methylated genes' British Journal of Dermatology, vol. 166, no. 4, O-21, pp. e23-e23. DOI:
10.1111/j.1365-2133.2012.10903.x

Research output: Contribution To Journal



Purdie, K, Gibbon, K, Proby, C, Leigh, I, Harwood, C & Teh, T 2012,

'A quantitative molecular diagnostic system for predicting progression of vulval intraepithelial neoplasia to invasive squamous cell carcinoma' British Journal of Dermatology, vol. 166, no. 4, P-1, pp. e29-e29. DOI:
10.1111/j.1365-2133.2012.10903.x

Research output: Contribution To Journal



de Vries, E, Micallef, R, Brewster, DH, Gibbs, JH, Flohil, SC, Saksela, O, Sankila, R, Forrest, AD, Trakatelli, M, Coebergh, JWW, Proby, CM & EPIDERM Grp 2012,

'Population-Based Estimates of the Occurrence of Multiple vs First Primary Basal Cell Carcinomas in 4 European Regions' Archives of dermatology, vol. 148, no. 3, pp. 347-354. DOI:
10.1001/archdermatol.2011.2244

Research output: Contribution To Journal



Pourreyron, C, Reilly, L, Proby, C, Panteleyev, A, Fleming, C, Mc Lean, K, South, AP & Foerster, J 2012,

'Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical wnt signalling is repressed' PLo S ONE, vol. 7, no. 2. DOI:
10.1371/journal.pone.0031827

Research output: Contribution To Journal



Cheung, BB, Koach, J, Tan, O, Kim, P, Bell, JL, D'andreti, C, Sutton, S, Malyukova, A, Sekyere, E, Norris, M, Haber, M, Kavallaris, M, Cunningham, AM, Proby, C, Leigh, I, Wilmott, JS, Cooper, CL, Halliday, GM, Scolyer, RA & Marshall, GM 2012,

'The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro' Journal of Pathology, vol. 226, no. 3, pp. 451-462. DOI:
10.1002/path.2986

Research output: Contribution To Journal



Weissenborn, S, Neale, RE, Waterboer, T, Abeni, D, Bavinck, JNB, Green, AC, Harwood, CA, Euvrard, S, Feltkamp, MCW, de Koning, MNC, Naldi, L, Quint, WGV, Tessari, G, Proby, CM, Wieland, U & Pfister, H 2012,

'Beta-papillomavirus DNA loads in hair follicles of immunocompetent people and organ transplant recipients' Medical Microbiology and Immunology, vol. 201, no. 2, pp. 1-9. DOI:
10.1007/s00430-011-0212-3

Research output: Contribution To Journal



Sampogna, F, Bavinck, JNB, Pawlita, M, Abeni, D, Harwood, CA, Proby, CM, Feltkamp, MCW, Euvrard, S, Naldi, L, Neale, RE, Nindl, I, Pfister, H, Quint, WGV, Waterboer, T & EPI-HPV-UV-CA Grp 2012,

'Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients' Journal of General Virology, vol. 93, pp. 165-174. DOI:
10.1099/vir.0.035493-0

Research output: Contribution To Journal



Lambert, SR, Harwood, CA, Purdie, KJ, Gulati, A, Matin, RN, Romanowska, M, Cerio, R, Kelsell, DP, Leigh, IM & Proby, CM 2012,

'Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene' International Journal of Cancer, vol. 131, no. 3, pp. E216-E226. DOI:
10.1002/ijc.27333

Research output: Contribution To Journal



Wang, H, Lee, S, Lo Nigro, C, Lattanzio, L, Merlano, M, Monteverde, M, Matin, R, Purdie, K, Mladkova, N, Bergamaschi, D, Harwood, C, Syed, N, Szlosarek, P, Briasoulis, E, Mc Hugh, A, Thompson, A, Evans, A, Leigh, I, Fleming, C, Inman, GJ, Hatzimichael, E, Proby, C & Crook, T 2012,

'NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity' British Journal of Cancer, vol. 106, no. 8, pp. 1446-52. DOI:
10.1038/bjc.2012.95

Research output: Contribution To Journal



Hack, K, Reilly, L, Proby, C, Fleming, C, Leigh, I & Foerster, J 2012,

'Wnt5a inhibits the Cp G oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells' Clinical and experimental dermatology. DOI:
10.1111/j.1365-2230.2012.04362.x

Research output: Contribution To Journal



Lo Nigro, C, Monteverde, M, Lee, S, Lattanzio, L, Vivenza, D, Comino, A, Syed, N, Mc Hugh, A, Wang, H, Proby, C, Garrone, O, Merlano, M, Hatzimichael, E, Briasoulis, E, Gojis, O, Palmieri, C, Jordan, L, Quinlan, P, Thompson, A & Crook, T 2012,

'NT5E Cp G island methylation is a favourable breast cancer biomarker' British Journal of Cancer, vol. 107, no. 1, pp. 75-83. DOI:
10.1038/bjc.2012.212

Research output: Contribution To Journal



de Vries, E, Trakatelli, M, Kalabalikis, D, Ferrandiz, L, Ruiz-de-Casas, A, Moreno-Ramirez, D, Sotiriadis, D, Ioannides, D, Aquilina, S, Apap, C, Micallef, R, Scerri, L, Ulrich, M, Pitkanen, S, Saksela, O, Altsitsiadis, E, Hinrichs, B, Magnoni, C, Fiorentini, C, Majewski, S, Ranki, A, Stockfleth, E, Proby, C & EPIDERM Grp 2012,

'Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study' British Journal of Dermatology, vol. 167, pp. 1-13. DOI:
10.1111/j.1365-2133.2012.11081.x

Research output: Contribution To Journal



Ferrandiz, L, Ruiz-de-Casas, A, Trakatelli, M, de Vries, E, Ulrich, M, Aquilina, S, Saksela, O, Majewski, S, Ranki, A, Proby, C, Magnoni, C, Pitkanen, S, Kalokasidis, K, Siskou, S, Hinrichs, B, Altsitsiadis, E, Stockfleth, E, Moreno-Ramirez, D & EPIDERM Grp 2012,

'Assessing physicians' preferences on skin cancer treatment in Europe' British Journal of Dermatology, vol. 167, no. S2, pp. 29-35. DOI:
10.1111/j.1365-2133.2012.11084.x

Research output: Contribution To Journal



Verschooten, L, Barrette, K, Van Kelst, S, Romero, NR, Proby, C, De Vos, R, Agostinis, P & Garmyn, M 2012,

'Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells' PLo S ONE, vol. 7, no. 10, e48264, pp. -. DOI:
10.1371/journal.pone.0048264

Research output: Contribution To Journal



Watt, S, Pourreyron, C, Purdie, K, Hogan, C, Cole, CL, Foster, N, Pratt, N, Bourdon, J-C, Appleyard, V, Murray, K, Thompson, A, Mao, X, Mein, C, Bruckner-Tuderman, L, Evans, A, Mc Grath, JA, Proby, CM, Foerster, J, Leigh, I & South, A 2011,

'Integrative m RNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma' Oncogene, vol. 30, no. 46, pp. 4666-4677. DOI:
10.1038/onc.2011.180

Research output: Contribution To Journal



Wang, NJ, Sanborn, Z, Arnett, KL, Bayston, LJ, Liao, W, Proby, CM, Leigh, IM, Collisson, EA, Gordon, PB, Jakkula, L, Pennypacker, S, Zou, Y, Sharma, M, North, JP, Vemula, SS, Mauro, TM, Neuhaus, IM, Le Boit, PE, Hur, JS, Park, K, Huh, N, Kwok, P-Y, Arron, ST, Massion, PP, Bale, AE, Haussler, D, Cleaver, JE, Gray, JW, Spellman, PT, South, AP, Aster, JC, Blacklow, SC & Cho, RJ 2011,

'Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma' Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 43, pp. 17761-17766. DOI:
10.1073/pnas.1114669108

Research output: Contribution To Journal



Wang, H, Mc Hugh, A, Matin, R, Fleming, C, Leigh, I, Harwood, C, Crook, T, Inman, G & Proby, C 2011,

'Epigenetic Dysregulation of Novel Genes in Melanoma' Journal of Investigative Dermatology, vol. 131, pp. S114-S114. DOI:
10.1038/jid.2011.214

Research output: Contribution To Journal



Pourreyron, C, Mc Lean, K, Reilly, L, Proby, C, Panteleyev, A, Evans, A, Leigh, I, South, A & Foerster, J 2011,

'Specific upregulation of non-canonical wnt signalling in non-melanoma skin cancer: Wnt 5a is strongly expressed and controls directional migration' Journal of Investigative Dermatology, vol. 131, pp. S28-S28. DOI:
10.1038/jid.2011.75

Research output: Contribution To Journal



Purdie, K, Gibbon, K, Chaplin, T, Young, B, Leigh, I, Proby, C & Harwood, C 2011,

'High Resolution Genomic Profiling of Vulval Neoplasia Reveals Genetic Differences between Human Papillomavirus-Associated and Human Papillomavirus-Independent Tumours' Journal of Investigative Dermatology, vol. 131, pp. S29-S29. DOI:
10.1038/sj.bjc.6605589

Research output: Contribution To Journal



Hack, K, Proby, C, Fleming, C, Leigh, I, Mc Lean, K, Reilly, L & Foerster, J 2011,

'Wnt5a inhibits maturation and interferon alpha production by human plasmacytoid dendritic cells' Journal of Investigative Dermatology, vol. 131, pp. S91-S91. DOI:
10.1038/jid.2011.75

Research output: Contribution To Journal



Mladkova, N, Mc Hugh, A, Down, T, Rakyan, V, Proby, C & Harwood, C 2011,

'Identification of Differentially Methylated Genes in Cutaneous Squamous Cell Carcinoma from Epidermolysis Bullosa Patients and Normal Population' Journal of Investigative Dermatology, vol. 131, pp. S24-S24. DOI:
10.1038/jid.2011.75

Research output: Contribution To Journal



Romanowska, M, Lambert, SR, Foerster, JP, Purdie, KJ, Harwood, CA & Proby, CM 2011,

'Protein tyrosine phosphatase receptor type delta (PTPRD) stable knockdown leads to increased proliferation in c SCC-derived keratinocytes' Journal of Investigative Dermatology, vol. 131, pp. S26-S26. DOI:
10.1038/jid.2011.214

Research output: Contribution To Journal



Casabonne, D, Newton, R, Ismail, F, Mitchell, L, Lally, A, Imko-Walczuk, B, Wojnarowska, F, Proby, C & Harwood, C 2011,

'The impact of dedicated dermatology services on the awareness of cutaneous cancer risk and on attitudes towards UV exposure among transplant recipients' Journal of Epidemiology and Community Health, vol. 65, pp. A107-A107. DOI:
10.1136/jech.2011.142976d.39

Research output: Contribution To Journal



Proby, CM, Harwood, CA, Neale, RE, Green, AC, Euvrard, S, Naldi, L, Tessari, G, Feltkamp, MCW, De Koning, MNC, Quint, WGV, Waterboer, T, Pawlita, M, Weissenborn, S, Wieland, U, Pfister, H, Stockfleth, E, Nindl, I, Abeni, D, ter Schegget, J, Bavinck, JNB & EPI-HPV-UV-CA Grp 2011,

'A Case-Control Study of Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients' American Journal of Transplantation, vol. 11, no. 7, pp. 1498-1508. DOI:
10.1111/j.1600-6143.2011.03589.x

Research output: Contribution To Journal



Mladkova, N, Cerio, R, Proby, C & Harwood, C 2011,

'Merkel cell carcinoma: the possible pathogenic role of viruses and the dilemma of managing metastatic skin malignancy in the context of immunosuppression' British Journal of Dermatology, vol. 164, no. 6, pp. 1410-1410. DOI:
10.1111/j.1365-2133.2011.10408.x

Research output: Contribution To Journal



Matin, RN, Ismail, F, Proby, CM, Mc Gregor, JM, Moir, G, Cerio, R & Harwood, CA 2011,

'Cutaneous melanoma in candidates for renal transplantation: what are the risks?' British Journal of Dermatology, vol. 164, no. 6, pp. 1412-1412. DOI:
10.1111/j.1365-2133.2011.10391.x

Research output: Contribution To Journal



Wood, J, Pring, M, Eveson, JW, Price, N, Proby, CM & Hague, A 2011,

'Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluorouracil-induced apoptosis' British Journal of Cancer, vol. 104, no. 9, pp. 1459-1471. DOI:
10.1038/bjc.2011.111

Research output: Contribution To Journal



Wang, H, Mc Hugh, AT, Matin, R, Fleming, C, Leigh, IM, Harwood, C, Crook, T, Inman, G & Proby, C 2011,

'Epigenetic dysregulation of novel candidate genes in malignant melanoma' British Journal of Dermatology, vol. 164, no. 4, pp. 916-916. DOI:
10.1111/j.1365-2133.2011.10279.x

Research output: Contribution To Journal



Lambert, SR, Mladkova, N, Gulati, A, Leigh, I, Harwood, CA & Proby, C 2011,

'Microarray expression profiling identifies novel targets and pathways involved in cutaneous squamous cell carcinoma oncogenesis' British Journal of Dermatology, vol. 164, no. 4, pp. 933-934. DOI:
10.1111/j.1365-2133.2011.10279.x

Research output: Contribution To Journal



Purdie, KJ, Chaplin, T, Gibbon, K, Young, BD, Leigh, I, Proby, C & Harwood, CA 2011,

'High resolution microarray analysis of vulval neoplasia reveals genetic differences between human papillomavirus-positive and negative tumours' British Journal of Dermatology, vol. 164, no. 4, pp. 935-935. DOI:
10.1111/j.1365-2133.2011.10279.x

Research output: Contribution To Journal



Mladkova, N, Mc Hugh, A, Down, T, Rakyan, V, South, A, Proby, C & Harwood, C 2011,

'Methylation profiling of cutaneous squamous cell carcinoma' British Journal of Dermatology, vol. 164, no. 4, pp. 932-933. DOI:
10.1111/j.1365-2133.2011.10279.x

Research output: Contribution To Journal



Romanowska, M, Lambert, SR, Purdie, K, Mc Hugh, A, Harwood, CA, Foerster, J & Proby, CM 2011,

'STAT3 as a potential substrate for protein tyrosine phosphatase receptor delta (PTPRD) in cutaneous squamous cell carcinoma' British Journal of Dermatology, vol. 164, no. 4, pp. 936-936. DOI:
10.1111/j.1365-2133.2011.10279.x

Research output: Contribution To Journal



Mladkova, N, Kader, P, Harwood, C & Proby, C 2011,

'Are immunosuppressed patients at greater risk of Merkel cell polyomavirus in non-melanoma skin cancer?' British Journal of Dermatology, vol. 164, no. 4, pp. 937-937. DOI:
10.1111/j.1365-2133.2011.10279.x

Research output: Contribution To Journal



Harden, PN, Hoogendijk-van den Akker, JM, Bouwes-Bavinck, JN, Proby, CM, Hoitsma, AJ, Wolterbeck, R & de Fifter, JW 2011,

'Reduced rate of cutaneous squamous cell carcinoma in a randomised, prospective, multi-centre controlled trial of conversion to sirolimus-based immunosuppression: The RESCUE Trial' Transplant International, vol. 24, no. S2, LB-O-006, pp. 94-95. DOI:
10.1111/j.1432-2277.2011.01346.x

Research output: Contribution To Journal



Veitch, D, Dobbie, H, Cerio, R, Wijesuriya, N, Mc Gregor, JM, Proby, CM, Dhoat, S & Harwood, CA 2011,

'Calciphylaxis: a case series' British Journal of Dermatology, vol. 165, no. S1, P_13, pp. 25-26. DOI:
10.1111/j.1365-2133.2011.10277.x

Research output: Contribution To Journal



Claerhout, S, Verschooten, L, Van Kelst, S, De Vos, R, Proby, C, Agostinis, P & Garmyn, M 2010,

'Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma' International Journal of Cancer, vol. 127, no. 12, pp. 2790-2803. DOI:
10.1002/ijc.25300

Research output: Contribution To Journal



Bavinck, JNB, Neale, RE, Abeni, D, Euvrard, S, Green, AC, Harwood, CA, de Koning, MNC, Naldi, L, Nindl, I, Pawlita, M, Pfister, H, Proby, CM, Quint, WGV, ter Schegget, J, Waterboer, T, Weissenborn, S, Feltkamp, MCW & EPI-HPV-UV-CA Grp 2010,

'Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma' Cancer Research, vol. 70, no. 23, pp. 9777-9786. DOI:
10.1158/0008-5472.CAN-10-0352

Research output: Contribution To Journal



Purdie, KJ, Pourreyron, C, Fassihi, H, Cepeda-Valdes, R, Frew, JW, Volz, A, Weissenborn, SJ, Pfister, H, Proby, CM, Bruckner-Tuderman, L, Murrell, DF, Salas-Alanis, JC, Mc Grath, JA, Leigh, IM, Harwood, CA & South, AP 2010,

'No Evidence That Human Papillomavirus Is Responsible for the Aggressive Nature of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma' Journal of Investigative Dermatology, vol. 130, no. 12, pp. 2853-2855. DOI:
10.1038/jid.2010.243

Research output: Contribution To Journal



Proby, C, Harwood, C, Storey, A & Leigh, I 2010,

'Viral Oncogenesis and Skin Cancers' Journal of Pathology, vol. 222, pp. S14-S15. DOI:
10.1002/path.2770

Research output: Contribution To Journal



Watt, S, Pourreyron, C, Foerster, J, Hogan, C, Purdie, K, Bruckner-Tuderman, L, Proby, C, Mc Grath, J, Leigh, I & South, A 2010,

'Polo-like kinase 1 inhibitors hold potential as targeted therapies for squamous cell carcinoma' Journal of Investigative Dermatology, vol. 130, pp. S51-S51. DOI:
10.1038/jid.2010.71

Research output: Contribution To Journal



Verschooten, L, Smaers, K, Van Kelst, S, Proby, C, Maes, D, Declercq, L, Agostinis, P & Garmyn, M 2010,

'The Flavonoid Luteolin Increases the Resistance of Normal, but Not Malignant Keratinocytes, Against UVB-Induced Apoptosis' Journal of Investigative Dermatology, vol. 130, no. 9, pp. 2277-2285. DOI:
10.1038/jid.2010.124

Research output: Contribution To Journal



de Koning, MNC, ter Schegget, J, Eekhof, JAH, Kamp, M, Kleter, B, Gussekloo, J, Feltkamp, MCW, Bavinck, JNB, Purdie, KJ, Bunker, CB, Proby, CM, Meys, R, Harwood, CA & Quint, WGV 2010,

'Evaluation of a Novel Broad-Spectrum PCR-Multiplex Genotyping Assay for Identification of Cutaneous Wart-Associated Human Papillomavirus Types' Journal of Clinical Microbiology, vol. 48, no. 5, pp. 1706-1711. DOI:
10.1128/JCM.02122-09

Research output: Contribution To Journal



Watt, SA, Pourreyron, C, Foerster, J, Hogan, C, Purdie, K, Bruckner-Tuderman, L, Proby, C, Mc Grath, JA, Leigh, IM & South, AP 2010,

'Identification of polo-like kinase 1 as a potential therapeutic target in squamous cell carcinoma' British Journal of Dermatology, vol. 162, no. 4, pp. 923-923. DOI:
10.1111/j.1365-2133.2010.09700.x

Research output: Contribution To Journal



Lambert, SR, Purdie, K, Gulati, A, Leigh, IM, Kelsell, DP, Harwood, CA & Proby, C 2010,

'PTPRD microdeletions are associated with metastatic cutaneous squamous cell carcinoma' British Journal of Dermatology, vol. 162, no. 4, pp. 923-924. DOI:
10.1111/j.1365-2133.2010.09700.x

Research output: Contribution To Journal



Purdie, KJ, Harwood, CA, Chaplin, T, Gibbon, K, Singh, N, Young, BD, Cazier, JB, Leigh, IM & Proby, CM 2010,

'High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia' British Journal of Dermatology, vol. 162, no. 4, pp. 945-945.

Research output: Contribution To Journal



Romanowska, M, Proby, CM, Lambert, SR, Purdie, K, Gulati, A, Leigh, IM, Harwood, CA & Foerster, J 2010,

'Protein tyrosine phosphatase receptor type delta (PTPRD) is expressed in normal and cutaneous squamous cell carcinoma-derived keratinocytes' British Journal of Dermatology, vol. 162, no. 4, pp. 945-946.

Research output: Contribution To Journal



Ng, YZ, Pourreyron, C, Proby, C, Salas, J, Murrell, DF, Mc Grath, JA, Lane, EB, Leigh, IM & South, AP 2010,

'Dermal fibroblast expression profiling implicates tumour microenvironment in the development of aggressive squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa' British Journal of Dermatology, vol. 162, no. 4, pp. 948-948. DOI:
10.1111/j.1365-2133.2010.09700.x

Research output: Contribution To Journal



Gulati, A, Harwood, CA, Purdie, K, Leigh, IM, Kelsell, DP & Proby, CM 2010,

'Identification of therapeutic and prognostic biomarkers in keratinocyte carcinogenesis' British Journal of Dermatology, vol. 162, no. 4, pp. 949-949. DOI:
10.1111/j.1365-2133.2010.09700.x

Research output: Contribution To Journal



Matin, RN, Chikh, A, Warnes, G, Proby, CM, Leigh, IM, Harwood, CA & Bergamaschi, D 2010,

'p63 is implicated in apoptotic dysregulation in melanoma' British Journal of Dermatology, vol. 162, no. 4, pp. 921-921. DOI:
10.1111/j.1365-2133.2011.10279.x

Research output: Contribution To Journal



Purdie, KJ, Harwood, CA, Gibbon, K, Chaplin, T, Young, BD, Cazier, JB, Singh, N, Leigh, IM & Proby, CM 2010,

'High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia' British Journal of Cancer, vol. 102, no. 6, pp. 1044-1051. DOI:
10.1038/sj.bjc.6605589

Research output: Contribution To Journal



Casabonne, D, Lally, A, Mitchell, L, Michael, KM, Waterboer, T, Pawlita, M, Imko-Walczuk, B, Wojnarowska, F, Proby, C, Harwood, C & Newton, R 2010,

'Erratum - A case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors ' International Journal of Cancer, vol. 126, no. 5, pp. 1282. DOI:
10.1002/ijc.24974

Research output: Contribution To Journal



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