Antimicrobial use and resistance, infection epidemiology, multidisciplinary research, health informatics
Current grants include:
AMR Cross Council Initiative / ESRC
Understanding and improving antimicrobial prescribing in care homes: a multidisciplinary approach
Marwick CA, Guthrie B, Grant S, Donnan P, Francis J, Lorencatto F, Hughes C
Sept 2017-Aug 2021
Medical Research Foundation
National PhD Training Programme on Antimicrobial Resistance
Avison M, Bailey A, Buller H, Chandler C, Crook D, Dockrell D, Dowson C, Grant A, Hayward A, Holmes A, Holmes M, Marwick C, Singer A, Stekel D, Walker S, Wälti C
Sept 2017- Dec 2022
Scottish Infection Research Network (SIRN)/CSO
Scottish Healthcare Associated Infection Prevention Institute (SHAIPI), SIRN Consortium.
Leonard A, Aanensen D, Bennie M, Coia J, Currie K, Evans T, Gillespie S, Holden M, Knussen C, Lang S, Marwick C, McCowan C, Morris K, Parcell B, Parkhill J, Phillips G, Price L, Reilly J, Robertson C, Walsh T
Apr 2015-Mar 2020
Regular commitments include:
- Postgraduate research supervision, including PhD students and medical undergraduate student projects
- Postgraduate Research Lead for Division of Population Health & Genomics
- Deputy Chair of the School of Medicine Research Postgraduate Committee
- Undergraduate clinical teaching of year 4 medical students
'Prioritizing research areas for antibiotic stewardship programmes in hospitals: a behavioural perspective consensus paper' Clinical Microbiology and Infection.
'Identifying care-home residents in routine healthcare datasets: a diagnostic test accuracy study of five methods' Age and Ageing.
'Risk of Acute Kidney Injury following community prescription of antibiotics: self-controlled case series' Nephrology Dialysis Transplantation.
'A framework for ensuring a balanced accounting of the impact of antimicrobial stewardship interventions' Journal of Antimicrobial Chemotherapy, vol. 72, no. 12, pp. 3223-3231.
'Impact of antimicrobial stewardship interventions on Clostridium difficile infection and clinical outcomes: segmented regression analyses' Journal of Antimicrobial Chemotherapy, vol. 73, no. 2, pp. 517-526.
'Hospital antimicrobial stewardship: the way forward' Lancet Infectious Diseases, vol. 17, no. 11, pp. 1119-1120.
'Risk factors for resistance and MDR in community urine isolates: population-level analysis using the NHS Scotland Infection Intelligence Platform' Journal of Antimicrobial Chemotherapy, vol. 73, no. 1, pp. 223-230.
'Has primary care antimicrobial use really been increasing? Comparison of changes in different prescribing measures for a complete geographic population 1995-2014' Journal of Antimicrobial Chemotherapy, vol. 72, no. 10, pp. 2921-2930.
'Building a national Infection Intelligence Platform to improve antimicrobial stewardship and drive better patient outcomes: the Scottish experience' Journal of Antimicrobial Chemotherapy, vol. 72, no. 10, pp. 2938-2942.
'Evaluation of a complex intervention to improve primary care prescribing: a phase IV segmented regression interrupted time series analysis ' British Journal of General Practice, vol. 67, no. 658, pp. e352-e360.
'Oral and topical antibiotics for clinically infected eczema in children: a pragmatic randomized controlled trial in ambulatory care' Annals of Family Medicine, vol. 15, no. 2, pp. 124-130.
'Cumulative and temporal associations between antimicrobial prescribing and community-associated Clostridium difficile infection: population-based case-control study using administrative data' Journal of Antimicrobial Chemotherapy, vol. 72, no. 4, pp. 1193-1201.
'Interventions to improve antibiotic prescribing practices for hospital inpatients' Cochrane Database of Systematic Reviews, vol. 2017, no. 2, CD003543, pp. 1-368.
'Reduction in post-operative acute kidney injury following a change in antibiotic prophylaxis policy for orthopaedic surgery: an observational study' Journal of Antimicrobial Chemotherapy, vol. 71, no. 9, pp. 2598-2605.
'The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study' Eurosurveillance, vol. 21, no. 33, Article 2, pp. 1-12.
'Herpes simplex encephalitis: unusual imaging appearances' BMJ Case Reports, vol. 2016.
'A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the Child Ren with Eczema, Antibiotic Management (CREAM) study' Health Technology Assessment, vol. 20, no. 19, pp. 1-84.
'MRSA: treating people with infection' BMJ Clinical Evidence.
'Hospital-acquired pneumonia incidence and diagnosis in older patients' Age and Ageing, vol. 45, no. 1, pp. 171-174.
'Risk of postoperative acute kidney injury in patients undergoing orthopaedic surgery—development and validation of a risk score and effect of acute kidney injury on survival: observational cohort study' BMJ, vol. 351, h5639.
'Time series analysis of the impact of an intervention in Tayside, Scotland to reduce primary care broad-spectrum antimicrobial use' Journal of Antimicrobial Chemotherapy, vol. 70, no. 8, dkv095, pp. 2397-2404.
'Reduction in broad-spectrum Gram-negative agents by diverse prescribing of aztreonam within NHS Tayside' Journal of Antimicrobial Chemotherapy, vol. 70, no. 8, pp. 2421-2423.
'Interventions to prevent non-critical care hospital acquired pneumonia – a systematic review' European Geriatric Medicine, vol. 6, no. 4, pp. 336-340.
'Time for action - improving the design and reporting of behaviour change interventions for antimicrobial stewardship in hospitals: early findings from a systematic review' International Journal of Antimicrobial Agents, vol. 45, no. 3, pp. 203-212.
'A multifaceted intervention to improve sepsis management in general hospital wards with evaluation using segmented regression of interrupted time series' BMJ Quality & Safety, vol. 23, no. 12, e2.
'Risk of AKI with gentamicin as surgical prophylaxis' Journal of the American Society of Nephrology, vol. 25, no. 11, pp. 2625-2632.
'Valuation of hospital bed-days released by infection control programs: a comparison of methods' Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America, vol. 35, no. 10, pp. 1294-1297.
'Identifying which septic patients have increased mortality risk using severity scores: a cohort study' BMC Anesthesiology, vol. 14, no. 1, 1.
'NSAIDs and cardiovascular risk' Kidney International, vol. 85, no. 1, pp. 211.
'Linking process measures to outcome for patients with complicated urinary tract infection: it's complicated' Clinical Infectious Diseases, vol. 58, no. 2, pp. 170-172.
'Effects of peri-operative nonsteroidal anti-inflammatory drugs on postoperative kidney function for adults with normal kidney function' Cochrane Database of Systematic Reviews, vol. 2014, no. 8, CD011274, pp. 1-16.
'Prophylactic gentamicin and flucloxacillin is associated with increased rates of acute kidney injury in orthopaedic surgery' Nephrology Dialysis Transplantation, vol. 28, no. supp. 1, MP146, pp. i343-i343.
'Community acquired infections in older patients admitted to hospital from care homes versus the community: cohort study of microbiology and outcomes' BMC Geriatrics, vol. 13, 12.
'Community-associated Clostridium difficile infection among older people in Tayside, Scotland, is associated with antibiotic exposure and care home residence: cohort study with nested case-control' Journal of Antimicrobial Chemotherapy, vol. 68, no. 12, pp. 2927-2933.
'Audit of Staphylococcus aureus bacteraemia management in NHS Tayside and comparison with European Antibiotic Strategies study group international quality standards' Journal of Antimicrobial Chemotherapy, vol. 67, no. 9, pp. 2304-2306.
'Prospective study of severity assessment and management of acute medical admissions with skin and soft tissue infection' Journal of Antimicrobial Chemotherapy, vol. 67, no. 4, pp. 1016-1019.
'Cellulitis: Treat all cases of cellulitis with anti-staphylococcal antibiotics' BMJ, vol. 345, no. 7873, e5876.
'Severity assessment of skin and soft tissue infections: cohort study of management and outcomes for hospitalized patients' Journal of Antimicrobial Chemotherapy, vol. 66, no. 2, pp. 387-397.
'MRSA: treating people with infection' BMJ Clinical Evidence, vol. 2010.
'MRSA as a cause of lung infection including airway infection, community-acquired pneumonia and hospital-acquired pneumonia' European Respiratory Journal, vol. 34, no. 6, pp. 1470-1476.
'Care bundles: the holy grail of infectious risk management in hospital?' Current Opinion in Infectious Diseases, vol. 22, no. 4, pp. 364-369.
'A survey on public knowledge and perceptions of methicillin-resistant Staphylococcus aureus' Journal of Antimicrobial Chemotherapy, vol. 63, no. 1, pp. 209-214.
'Appropriate vs. inappropriate antimicrobial therapy' Clinical Microbiology and Infection, vol. 14, pp. 15-21.
'Quality of care in sepsis management: development and testing of measures for improvement' Journal of Antimicrobial Chemotherapy, vol. 60, no. 3, pp. 694-697.
'Infection control and management of MRSA: assessing the knowledge of staff in an acute hospital setting' Journal of Hospital Infection, vol. 66, no. 1, pp. 29-33.
'Improving antimicrobial prescribing through knowledge and skills' Journal of Antimicrobial Chemotherapy, vol. 59, no. 4, pp. 819-820.
'Treatment of Staphylococcus aureus bacteraemia' British Medical Journal, vol. 333, no. 7564, pp. 397-397.