Bruce Guthrie

+44 (0)1382 383740
Head of Population Health Sciences Division, Professor of Primary Care Medicine and Honorary Consultant NHS Fife

Bio

Biography

I am Professor of Primary Care Medicine at the University of Dundee Medical School where I carry out applied research to translate basic and clinical research into effective and reliable clinical practice. I am additionally an Honorary Consultant in NHS Fife and a General Practitioner in Cardenden in Fife. I was previously a Medical Research Council Health Services Research Fellow at University of Edinburgh, an National Institute for Health Research post-doctoral research fellow at University of Dundee, and a 2006/7 Commonwealth Fund Harkness Fellow in Healthcare Policy at University of California San Francisco where I was also a Visiting Professor in 2010. I regularly review for various grant-making bodies and journals, contribute to undergraduate and postgraduate medical teaching, and supervise and examine MSc and PhD students in Dundee and other universities. As well as conducting research, I serve or have served on a number of National Health Service advisory bodies, including the National Institute for Health and Clinical Excellence (NICE) Quality and Outcomes Framework Indicators Advisory Committee (which recommended which quality indicators should be included in the UK primary care pay for performance programme) where I chaired the Thresholds, Review and Retiral Sub-committee, and the Scottish Government Polypharmacy Working Group. I was the chair of the guideline development group of the NICE Multimorbidity Clinical Guideline published in late 2016. 

Research

My main research interests are the quality and safety of healthcare, particularly in primary care and currently focused on prescribing quality and safety, multimorbidity the organisation of healthcare. I am a mixed methods researcher and collaborate with researchers from a wide range of disciplines and institutions. The methods I use include quantitative analysis of large, routine datasets; cluster randomised trials with mixed methods parallel process evaluations; and qualitative analysis of interview and observational data. My recent and current work includes development and evaluation of interventions to improve polypharmacy, examination of the implications of competing mortality risk for single disease risk prediction, and examination of the applicability of trial evidence to clinical populations. 

Publications

Minchin, M, Roland, M, Richardson, J, Rowark, S & Guthrie, B 2018,

'Quality of Care in the United Kingdom after Removal of Financial Incentives' New England Journal of Medicine, vol. 379, no. 10, pp. 948-957. DOI:
10.1056/NEJMsa1801495

Research output: Contribution To Journal



Chaplin, K, Bower, P, Man, M-S, Brookes, ST, Gaunt, D, Guthrie, B, Mann, C, Mercer, SW, Rafi, I, Shaw, ARG & Salisbury, C 2018,

'Understanding usual care for patients with multimorbidity: baseline data from a cluster-randomised trial of the 3D intervention in primary care' BMJ Open, vol. 8, no. 8, e019845. DOI:
10.1136/bmjopen-2017-019845,
10.1136/bmjopen-2017-019845

Research output: Contribution To Journal



Burton, JK, Marwick, CA, Galloway, J, Hall, C, Nind, T, Reynish, EL & Guthrie, B 2018,

'Identifying care-home residents in routine healthcare datasets: a diagnostic test accuracy study of five methods' Age and Ageing. DOI:
10.1093/ageing/afy137

Research output: Contribution To Journal



Nind, T, Galloway, J, Mc Allister, G, Scobbie, D, Bonney, W, Hall, C, Tramma, L, Reel, P, Groves, M, Appleby, P, Doney, A, Guthrie, B & Jefferson, E 2018,

'The Research Data Management Platform (RDMP): A novel, process driven, open-source tool for the management of longitudinal cohorts of clinical data' Giga Science, vol. 7, no. 7, giy060. DOI:
10.1093/gigascience/giy060

Research output: Contribution To Journal



Toma, M, Dreischulte, T, Gray, NM, Campbell, D & Guthrie, B 2018,

'Balancing measures or a balanced accounting of improvement impact: a qualitative analysis of individual and focus group interviews with improvement experts in Scotland' BMJ Quality & Safety, vol. 27, no. 7, pp. 547-556. DOI:
10.1136/bmjqs-2017-006554

Research output: Contribution To Journal



Mann, C, Shaw, A, Wye, L, Salisbury, C & Guthrie, B 2018,

'A computer template to enhance patient-centredness in multimorbidity reviews: a qualitative evaluation in primary care' British Journal of General Practice, vol. 68, no. 672, pp. e495-e504. DOI:
10.3399/bjgp18X696353

Research output: Contribution To Journal



Salisbury, C, Man, M-S, Bower, P, Guthrie, B, Chaplin, K, Gaunt, DM, Brookes, S, Fitzpatrick, B, Gardner, C, Hollinghurst, S, Lee, V, Mc Leod, J, Mann, C, Moffat, KR & Mercer, SW 2018,

'Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach' Lancet, vol. 392, no. 10141, pp. 41-50. DOI:
10.1016/S0140-6736(18)31308-4

Research output: Contribution To Journal



Burton, JK & Guthrie, B 2018,

'Identifying who lives in a care home-a challenge to be conquered' Age and Ageing, vol. 47, no. 3, pp. 322-323. DOI:
10.1093/ageing/afx200

Research output: Contribution To Journal



Grant, S & Guthrie, B 2018,

'Between demarcation and discretion: the medical-administrative boundary as a locus of safety in high-volume organisational routines' Social Science and Medicine, vol. 203, pp. 43-50. DOI:
10.1016/j.socscimed.2018.03.005

Research output: Contribution To Journal



Grant, S & Guthrie, B 2018,

'Efficiency and thoroughness trade-offs in high-volume organisational routines: an ethnographic study of prescribing safety in primary care' BMJ Quality & Safety, vol. 27, no. 3, pp. 199-206. DOI:
10.1136/bmjqs-2017-006917

Research output: Contribution To Journal



Guthrie, B & Mercer, SW 2018,

'Divided we fall: The commodification of primary medical care' BMJ, vol. 360, pp. 1-2. DOI:
10.1136/bmj.k787

Research output: Contribution To Journal



Kontopantelis, E, Mamas, MA, van Marwijk, H, Ryan, AM, Bower, P, Guthrie, B & Doran, T 2018,

'Chronic morbidity, deprivation and primary medical care spending in England in 2015-16: a cross-sectional spatial analysis' BMC Medicine, vol. 16, 19, pp. 1-13. DOI:
10.1186/s12916-017-0996-0

Research output: Contribution To Journal



Dreischulte, T, Grant, A, Hapca, A & Guthrie, B 2018,

'Process evaluation of the Data-driven Quality Improvement in Primary Care (DQIP) trial: Quantitative examination of variation between practices in recruitment, implementation and effectiveness' BMJ Open, vol. 8, no. 1, e017133, pp. 1-12. DOI:
10.1136/bmjopen-2017-017133

Research output: Contribution To Journal



Toma, M, Davey, PG, Marwick, CA & Guthrie, B 2017,

'A framework for ensuring a balanced accounting of the impact of antimicrobial stewardship interventions' Journal of Antimicrobial Chemotherapy, vol. 72, no. 12, pp. 3223-3231. DOI:
10.1093/jac/dkx312

Research output: Contribution To Journal



Stokes, J, Man, M-S, Guthrie, B, Mercer, SW, Salisbury, C & Bower, P 2017,

'The Foundations Framework for Developing and Reporting New Models of Care for Multimorbidity' Annals of Family Medicine, vol. 15, no. 6, pp. 570-577. DOI:
10.1370/afm.2150

Research output: Contribution To Journal



Guthrie, B, Gillies, J, Calderwood, C, Smith, G & Mercer, S 2017,

'Developing middle-ground research to support primary care transformation' British Journal of General Practice, vol. 67, no. 664, pp. 498-499. DOI:
10.3399/bjgp17X693209

Research output: Contribution To Journal



Marwick, CA, Guthrie, B & Davey, PG 2017,

'Hospital antimicrobial stewardship: the way forward' Lancet Infectious Diseases, vol. 17, no. 11, pp. 1119-1120. DOI:
10.1016/S1473-3099(17)30566-2

Research output: Contribution To Journal



Neilly, MDJ, Guthrie, B, Hernandez Santiago, V, Vadiveloo, T, Donnan, PT & Marwick, CA 2017,

'Has primary care antimicrobial use really been increasing? Comparison of changes in different prescribing measures for a complete geographic population 1995-2014' Journal of Antimicrobial Chemotherapy, vol. 72, no. 10, pp. 2921-2930. DOI:
10.1093/jac/dkx220

Research output: Contribution To Journal



Thompson, A, Guthrie, B & Payne, K 2017,

'Using the Payoff Time in Decision-Analytic Models: A Case Study for Using Statins in Primary Prevention' Medical Decision Making, vol. 37, no. 7, pp. 735-746. DOI:
10.1177/0272989X17700846

Research output: Contribution To Journal



Weatherburn, CJ, Guthrie, B, Mercer, SW & Morales, DR 2017,

'Comorbidities in adults with asthma: population-based cross-sectional analysis of 1.4 million adults in Scotland' Clinical and Experimental Allergy, vol. 47, no. 10, pp. 1246-1252. DOI:
10.1111/cea.12971

Research output: Contribution To Journal



Baldie, DJ, Guthrie, B, Entwistle, V & Kroll, T 2017,

'Exploring the impact and use of patients' feedback about their care experiences in general practice settings-a realist synthesis' Family Practice, vol. 35, no. 1, pp. 13-21. DOI:
10.1093/fampra/cmx067

Research output: Contribution To Journal



Zhang, X, Donnan, PT, Bell, S & Guthrie, B 2017,

'Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: Systematic review and meta-analysis' BMC Nephrology, vol. 18, no. 1, 256. DOI:
10.1186/s12882-017-0673-8

Research output: Contribution To Journal



Reynish, EL, Hapca, SM, De Souza, N, Cvoro, V, Donnan, PT & Guthrie, B 2017,

'Epidemiology and outcomes of people with dementia, delirium and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions' BMC Medicine, vol. 15, 140, pp. 1-12. DOI:
10.1186/s12916-017-0899-0

Research output: Contribution To Journal



Mc Lean, G, Hindle, JV, Guthrie, B & Mercer, SW 2017,

'Co-morbidity and polypharmacy in Parkinson's Disease: insights from a large Scottish primary care database' BMC Neurology, vol. 17, no. 1, 126, pp. 1-8. DOI:
10.1186/s12883-017-0904-4

Research output: Contribution To Journal



Tonelli, M, Wiebe, N, Straus, S, Fortin, M, Guthrie, B, James, MT, Klarenbach, SW, Tam-Tham, H, Lewanczuk, R, Manns, BJ, Quan, H, Ronksley, PE, Sargious, P, Hemmelgarn, BR & for the Alberta Kidney Disease Network 2017,

'Multimorbidity, dementia and health care in older people: a population-based cohort study' CMAJ Open , vol. 5, no. 3, pp. E623-E631. DOI:
10.9778/cmajo.20170052

Research output: Contribution To Journal



Mac Bride-Stewart, S, Marwick, C, Houston, N, Watt, I, Patton, A & Guthrie, B 2017,

'Evaluation of a complex intervention to improve primary care prescribing: a phase IV segmented regression interrupted time series analysis ' British Journal of General Practice, vol. 67, no. 658, pp. e352-e360. DOI:
10.3399/bjgp17X690437

Research output: Contribution To Journal



Baron Franco, B, Mc Lean, G, Mair, FS, Roger, VL, Guthrie, B & Mercer, SW 2017,

'Comorbidity and polypharmacy in chronic heart failure: a large cross-sectional study in primary care' British Journal of General Practice, vol. 67, no. 658, pp. e314-e320. DOI:
10.3399/bjgp17X690533

Research output: Contribution To Journal



Chetty, U, Mc Lean, G, Morrison, D, Agur, K, Guthrie, B & Mercer, SW 2017,

'Chronic obstructive pulmonary disease and comorbidities: a large cross-sectional study in primary care' British Journal of General Practice, vol. 67, no. 658, pp. e321-e328. DOI:
10.3399/bjgp17X690605

Research output: Contribution To Journal



Grant, S, Checkland, K, Bowie, P & Guthrie, B 2017,

'The role of informal dimensions of safety in high-volume organisational routines: an ethnographic study of test results handling in UK general practice' Implementation Science, vol. 12, no. 1, 56, pp. 1-12. DOI:
10.1186/s13012-017-0586-8

Research output: Contribution To Journal



Guthrie, B, Thompson, A, Dumbreck, S, Flynn, A, Alderson, P, Nairn, M, Treweek, S & Payne, K 2017,

'Better guidelines for better care: accounting for multimorbidity in clinical guidelines – structured examination of exemplar guidelines and health economic modelling' Health Services and Delivery Research, vol. 5, no. 16, pp. 1-179. DOI:
10.3310/hsdr05160

Research output: Contribution To Journal



Grant, A, Dreischulte, T & Guthrie, B 2017,

'Process evaluation of the Data-driven Quality Improvement in Primary Care (DQIP) trial: case-study evaluation of adoption and maintenance of a complex intervention to reduce high-risk primary care prescribing' BMJ Open, vol. 7, no. 3, e015281, pp. 1-12. DOI:
10.1136/bmjopen-2016-015281

Research output: Contribution To Journal



Morales, DR & Guthrie, B 2017,

'Off-label prescribing of antidepressants' BMJ, vol. 356, j849. DOI:
10.1136/bmj.j849

Research output: Contribution To Journal



Blane, DN, Mackay, D, Guthrie, B & Mercer, SW 2017,

'Smoking cessation interventions for patients with coronary heart disease and comorbidities: an observational cross-sectional study in primary care' British Journal of General Practice, vol. 67, no. 655, pp. e118-e129. DOI:
10.3399/bjgp16X688405

Research output: Contribution To Journal



Weatherburn, CJ, Heath, CA, Mercer, SW & Guthrie, B 2017,

'Physical and mental health comorbidities of epilepsy: population-based cross-sectional analysis of 1.5 million people in Scotland' Seizure, vol. 45, pp. 125-131. DOI:
10.1016/j.seizure.2016.11.013

Research output: Contribution To Journal



Morales, DR, Lipworth, BJ, Donnan, PT, Jackson, C & Guthrie, B 2017,

'Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study' BMC Medicine, vol. 15, 18. DOI:
10.1186/s12916-017-0781-0

Research output: Contribution To Journal



Clague, F, Mercer, SW, Mc Lean, G, Reynish, E & Guthrie, B 2017,

'Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data' Age and Ageing, vol. 46, no. 1, pp. 33-39. DOI:
10.1093/ageing/afw176

Research output: Contribution To Journal



Grant, A, Dreischulte, T & Guthrie, B 2017,

'Process evaluation of the data-driven quality improvement in primary care (DQIP) trial: active and less active ingredients of a multi-component complex intervention to reduce high-risk primary care prescribing' Implementation Science, vol. 12, 4, pp. 1-11. DOI:
10.1186/s13012-016-0531-2

Research output: Contribution To Journal



Farmer, C, Fenu, E, O'Flynn, N & Guthrie, B 2016,

'Clinical assessment and management of multimorbidity: summary of NICE guidance' BMJ, vol. 354, i4843. DOI:
10.1136/bmj.i4843

Research output: Contribution To Journal



Kontopantelis, E, Springate, DA, Ashcroft, DM, Valderas, JM, van der Veer, SN, Reeves, D, Guthrie, B & Doran, T 2016,

'Associations between exemption and survival outcomes in the UK's primary care pay-for-performance programme: a retrospective cohort study' BMJ Quality & Safety, vol. 25, no. 9, pp. 657-670. DOI:
10.1136/bmjqs-2015-004602

Research output: Contribution To Journal



Mercer, SW, O'Brien, R, Fitzpatrick, B, Higgins, M, Guthrie, B, Watt, G & Wyke, S 2016,

'The development and optimisation of a primary care-based whole system complex intervention (CARE Plus) for patients with multimorbidity living in areas of high socioeconomic deprivation' Chronic Illness, vol. 12, no. 3, pp. 165-181. DOI:
10.1177/1742395316644304

Research output: Contribution To Journal



Guthrie, B, Kavanagh, K, Robertson, C, Barnett, K, Treweek, S, Petrie, D, Ritchie, LD & Bennie, M 2016,

'Data feedback and behavioural change intervention to improve primary care prescribing safety (EFIPPS): multicentre, three arm, cluster randomised controlled trial' BMJ, vol. 354, i4079, pp. 1-9. DOI:
10.1136/bmj.i4079

Research output: Contribution To Journal



Morales, DR, Dreischulte, T, Lipworth, BJ, Donnan, PT, Jackson, C & Guthrie, B 2016,

'Respiratory effect of beta-blocker eye drops in asthma: population-based study and meta-analysis of clinical trials' British Journal of Clinical Pharmacology, vol. 82, no. 3, pp. 814-822. DOI:
10.1111/bcp.13006

Research output: Contribution To Journal



Roland, M & Guthrie, B 2016,

'Quality and Outcomes Framework: what have we learnt?' BMJ, vol. 354, i4060, pp. 1-4. DOI:
10.1136/bmj.i4060

Research output: Contribution To Journal



Ruscitto, A, Mercer, SW, Morales, D & Guthrie, B 2016,

'Accounting for multimorbidity in pay for performance: a modelling study using UK Quality and Outcomes Framework data' British Journal of General Practice, vol. 66, no. 649, pp. e561-e567. DOI:
10.3399/bjgp16X686161

Research output: Contribution To Journal



W. Mercer, S, Fitzpatrick, B, Guthrie, B, Fenwick, E, Grieve, E, Lawson, K, Boyer, N, Mc Connachie, A, Lloyd, SM, O'Brien, R, Watt, GCM & Wyke, S 2016,

'The care plus study - a whole system intervention to improve quality of life of primary care patients with multimorbidity in areas of high socioeconomic deprivation: exploratory cluster randomised controlled trial and cost-utility analysis' BMC Medicine, vol. 14, 88, pp. 1-10. DOI:
10.1186/s12916-016-0634-2

Research output: Contribution To Journal



Mann, C, Shaw, A, Guthrie, B, Wye, L, Man, M-S, Hollinghurst, S, Brookes, S, Bower, P, Mercer, S & Salisbury, C 2016,

'Protocol for a process evaluation of a cluster randomised controlled trial to improve management of multimorbidity in general practice: the 3D study' BMJ Open, vol. 6, no. 5, e011260. DOI:
10.1136/bmjopen-2016-011260

Research output: Contribution To Journal



Man, MS, Chaplin, K, Mann, C, Bower, P, Brookes, S, Fitzpatrick, B, Guthrie, B, Shaw, A, Hollinghurst, S, Mercer, S, Rafi, I, Thorn, J & Salisbury, C 2016,

'Improving the management of multimorbidity in general practice: protocol of a cluster randomised controlled trial (The 3D Study)' BMJ Open, vol. 6, no. 4, e011261, pp. 1-11. DOI:
10.1136/bmjopen-2016-011261

Research output: Contribution To Journal



Thompson, A, Guthrie, B & Payne, K 2016,

'Do Pills Have No Ills? Capturing the Impact of Direct Treatment Disutility' Pharmaco Economics, vol. 34, no. 4, pp. 333-336. DOI:
10.1007/s40273-015-0357-9

Research output: Contribution To Journal



Agur, K, Mc Lean, G, Hunt, K, Guthrie, B & Mercer, SW 2016,

'How does sex influence multimorbidity? Secondary analysis of a large nationally representative dataset' International Journal of Environmental Research and Public Health, vol. 13, no. 4, 391. DOI:
10.3390/ijerph43040391

Research output: Contribution To Journal



Dreischulte, T, Donnan, P, Grant, A, Hapca, A, Mc Cowan, C & Guthrie, B 2016,

'Safer Prescribing: A Trial of Education, Informatics, and Financial Incentives' New England Journal of Medicine, vol. 374, no. 11, pp. 1053-1064. DOI:
10.1056/NEJMsa1508955

Research output: Contribution To Journal



Grant, S, Mesman, J & Guthrie, B 2016,

'Spatio-temporal elements of articulation work in the achievement of repeat prescribing safety in UK general practice' Sociology of Health & Illness, vol. 38, no. 2, pp. 306-324. DOI:
10.1111/1467-9566.12308

Research output: Contribution To Journal



Steven, K, Dowell, J, Jackson, C & Guthrie, B 2016,

'Fair access to medicine? Retrospective analysis of UK medical schools application data 2009-2012 using three measures of socioeconomic status' BMC Medical Education, vol. 16, no. 1, 11. DOI:
10.1186/s12909-016-0536-1

Research output: Contribution To Journal



Hughes, LD, Cochrane, L, Mc Murdo, MET & Guthrie, B 2016,

'Psychoactive prescribing for older people-what difference does 15 years make?' International Journal of Geriatric Psychiatry, vol. 31, no. 1, pp. 49-57. DOI:
10.1002/gps.4288

Research output: Contribution To Journal



Mc Lean, G, Guthrie, B, Mercer, SW & Watt, GCM 2015,

'General practice funding underpins the persistence of the inverse care law: cross-sectional study in Scotland' British Journal of General Practice, vol. 65, no. 641, pp. e799-e805. DOI:
10.3399/bjgp15X687829

Research output: Contribution To Journal



Guthrie, B, Donnan, PT, Murphy, DJ, Makubate, B & Dreischulte, T 2015,

'Bad apples or spoiled barrels? Multilevel modelling analysis of variation in high-risk prescribing in Scotland between general practitioners and between the practices they work in' BMJ Open, vol. 5, no. 11, e008270. DOI:
10.1136/bmjopen-2015-008270

Research output: Contribution To Journal



Dowell, J, Norbury, M, Steven, K & Guthrie, B 2015,

'Widening access to medicine may improve general practitioner recruitment in deprived and rural communities: survey of GP origins and current place of work' BMC Medical Education, vol. 15, 165. DOI:
10.1186/s12909-015-0445-8

Research output: Contribution To Journal



Tonelli, M, Wiebe, N, Guthrie, B, James, MT, Quan, H, Fortin, M, Klarenbach, SW, Sargious, P, Straus, S, Lewanczuk, R, Ronksley, PE, Manns, BJ & Hemmelgarn, BR 2015,

'Comorbidity as a driver of adverse outcomes in people with chronic kidney disease' Kidney International, vol. 88, no. 4, pp. 859-866. DOI:
10.1038/ki.2015.228

Research output: Contribution To Journal



Heath, CA, Mercer, SW & Guthrie, B 2015,

'Vascular comorbidities in younger people with dementia: a cross-sectional population-based study of 616 245 middle-aged people in Scotland' Journal of Neurology, Neurosurgery and Psychiatry, vol. 86, no. 9, pp. 959-964. DOI:
10.1136/jnnp-2014-309033

Research output: Contribution To Journal



Cooper, S-A, Mc Lean, G, Guthrie, B, Mc Connachie, A, Mercer, S, Sullivan, F & Morrison, J 2015,

'Multiple physical and mental health comorbidity in adults with intellectual disabilities: population-based cross-sectional analysis' BMC Family Practice, vol. 16, 110. DOI:
10.1186/s12875-015-0329-3

Research output: Contribution To Journal



Dreischulte, T, Morales, DR, Bell, S & Guthrie, B 2015,

'Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin-angiotensin system inhibitors in the community increases the risk of acute kidney injury' Kidney International, vol. 88, no. 2, pp. 396-403. DOI:
10.1038/ki.2015.101

Research output: Contribution To Journal



Hernandez-Santiago, V, Marwick, CA, Patton, A, Davey, PG, Donnan, PT & Guthrie, B 2015,

'Time series analysis of the impact of an intervention in Tayside, Scotland to reduce primary care broad-spectrum antimicrobial use' Journal of Antimicrobial Chemotherapy, vol. 70, no. 8, dkv095, pp. 2397-2404. DOI:
10.1093/jac/dkv095

Research output: Contribution To Journal



Morales, DR, Guthrie, B, Lipworth, BJ, Jackson, C, Donnan, PT & Santiago, VH 2015,

'NSAID exacerbated respiratory disease: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity' Allergy, vol. 70, no. 7, pp. 828-835. DOI:
10.1111/all.12629

Research output: Contribution To Journal



Tonelli, M, Wiebe, N, Fortin, M, Guthrie, B, Hemmelgarn, BR, James, MT, Klarenbach, SW, Lewanczuk, R, Manns, BJ, Ronksley, P, Sargious, P, Straus, S, Quan, H & for the Alberta Kidney Disease Network 2015,

'Methods for identifying 30 chronic conditions: application to administrative data' BMC Medical Informatics and Decision Making, vol. 15, no. 31, 31. DOI:
10.1186/s12911-015-0155-5

Research output: Contribution To Journal



Guthrie, B, Makubate, B, Hernandez Santiago, V & Dreischulte, T 2015,

'The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995-2010' BMC Medicine, vol. 13, 74. DOI:
10.1186/s12916-015-0322-7

Research output: Contribution To Journal



Dumbreck, S, Flynn, A, Nairn, M, Wilson, M, Treweek, S, Mercer, SW, Alderson, P, Thompson, A, Payne, K & Guthrie, B 2015,

'Drug-disease and drug-drug interactions: systematic examination of recommendations in 12 UK national clinical guidelines' BMJ, vol. 350, h949. DOI:
10.1136/bmj.h949

Research output: Contribution To Journal



Wallace, E, Salisbury, C, Guthrie, B, Lewis, C, Fahey, T & Smith, SM 2015,

'Managing patients with multimorbidity in primary care' BMJ, vol. 350, h476. DOI:
10.1136/bmj.h476

Research output: Contribution To Journal



Ruscitto, A, Smith, BH & Guthrie, B 2015,

'Changes in opioid and other analgesic use 1995-2010: repeated cross-sectional analysis of dispensed prescribing for a large geographical population in Scotland' European Journal of Pain, vol. 19, no. 1, pp. 59-66. DOI:
10.1002/ejp.520

Research output: Contribution To Journal



Grant, S, Ring, A, Gabbay, M, Guthrie, B, Mc Lean, G, Mair, FS, Watt, G, Heaney, D & O'Donnell, C 2015,

'Soft governance, restratification and the 2004 general medical services contract: the case of UK primary care organisations and general practice teams' Sociology of Health & Illness, vol. 37, no. 1, pp. 30-51. DOI:
10.1111/1467-9566.12175

Research output: Contribution To Journal



Marwick, CA, Guthrie, B, Pringle, JEC, Evans, JMM, Nathwani, D, Donnan, PT & Davey, PG 2014,

'A multifaceted intervention to improve sepsis management in general hospital wards with evaluation using segmented regression of interrupted time series' BMJ Quality & Safety, vol. 23, no. 12, e2. DOI:
10.1136/bmjqs-2013-002176

Research output: Contribution To Journal



van Hecke, O & Guthrie, B 2014,

'Oral ketamine analgesia in chronic pain and problematic rise in blood pressure' BMJ Case Reports, vol. 2014, 207836. DOI:
10.1136/bcr-2014-207836

Research output: Contribution To Journal



Guthrie, B & Dreischulte, T 2014,

'Quality in primary care: Individual doctors matter, and pay for performance may reduce hospital admissions' BMJ, vol. 349, g6485. DOI:
10.1136/bmj.g6485

Research output: Contribution To Journal



Smith, DJ, Court, H, Mc Lean, G, Martin, D, Langan Martin, J, Guthrie, B, Gunn, J & Mercer, SW 2014,

'Depression and multimorbidity: a cross-sectional study of 1,751,841 patients in primary care' Journal of Clinical Psychiatry, vol. 75, no. 11, pp. 1202-1208. DOI:
10.4088/JCP.14m09147

Research output: Contribution To Journal



Court, H, Mc Lean, G, Guthrie, B, Mercer, SW & Smith, DJ 2014,

'Visual impairment is associated with physical and mental comorbidities in older adults: a cross-sectional study' BMC Medicine, vol. 12, 181. DOI:
10.1186/s12916-014-0181-7

Research output: Contribution To Journal



Barnett, KN, Bennie, M, Treweek, S, Robertson, C, Petrie, DJ, Ritchie, LD & Guthrie, B 2014,

'Effective Feedback to Improve Primary Care Prescribing Safety (EFIPPS) a pragmatic three-arm cluster randomised trial: designing the intervention (Clinical Trials.gov registration NCT01602705)' Implementation Science, vol. 9, 133. DOI:
10.1186/s13012-014-0133-9

Research output: Contribution To Journal



Gallacher, KI, Batty, GD, Mc Lean, G, Mercer, SW, Guthrie, B, May, CR, Langhorne, P & Mair, FS 2014,

'Stroke, multimorbidity and polypharmacy in a nationally representative sample of 1,424,378 patients in Scotland: implications for treatment burden' BMC Medicine, vol. 12, 151. DOI:
10.1186/PREACCEPT-1272432928127782

Research output: Contribution To Journal



Mc Lean, G, Langan Martin, J, Martin, DJ, Guthrie, B, Mercer, SW & Smith, DJ 2014,

'Standard cardiovascular disease risk algorithms underestimate the risk of cardiovascular disease in schizophrenia: evidence from a national primary care database' Schizophrenia Research, vol. 159, no. 1, pp. 176-181. DOI:
10.1016/j.schres.2014.07.022

Research output: Contribution To Journal



Dreischulte, T, Barnett, K, Madhok, V & Guthrie, B 2014,

'Use of oral anticoagulants in atrial fibrillation is highly variable and only weakly associated with estimated stroke risk: cross-sectional population database study' European Journal of General Practice, vol. 20, no. 3, pp. 181-189. DOI:
10.3109/13814788.2013.852535

Research output: Contribution To Journal



Mc Lean, G, Gunn, J, Wyke, S, Guthrie, B, Watt, GCM, Blane, DN & Mercer, SW 2014,

'The influence of socioeconomic deprivation on multimorbidity at different ages: a cross-sectional study' British Journal of General Practice, vol. 64, no. 624, pp. e440-e447. DOI:
10.3399/bjgp14X680545

Research output: Contribution To Journal



Sumukadas, D, Mc Murdo, MET, Mangoni, AA & Guthrie, B 2014,

'Temporal trends in anticholinergic medication prescription in older people: repeated cross-sectional analysis of population prescribing data' Age and Ageing, vol. 43, no. 4, pp. 515-521. DOI:
10.1093/ageing/aft199

Research output: Contribution To Journal



Morales, DR, Lipworth, BJ, Guthrie, B, Jackson, C, Donnan, PT & Santiago, VH 2014,

'Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials' Journal of Allergy and Clinical Immunology, vol. 134, no. 1, pp. 40-45.e10. DOI:
10.1016/j.jaci.2013.10.057

Research output: Contribution To Journal



Jones, NRV, Fischbacher, CM, Guthrie, B, Leese, G, Lindsay, RS, Mc Knight, JA, Pearson, D, Philip, S, Sattar, N, Wild, SH & Scottish Diabetes Research Network Epidemiology Group 2014,

'Factors associated with statin treatment for the primary prevention of cardiovascular disease in people within 2 years following diagnosis of diabetes in Scotland, 2006-2008' Diabetic Medicine, vol. 31, no. 6, pp. 640-646. DOI:
10.1111/dme.12409

Research output: Contribution To Journal



Mc Murdo, MET, Witham, MD, Johnston, D, Struthers, AD, Guthrie, B & Matthews, K 2014,

'Identifying older heart failure patients with major depression in primary care: a feasibility study' International Journal of Geriatric Psychiatry, vol. 29, no. 5, pp. 547-549. DOI:
10.1002/gps.4089

Research output: Contribution To Journal



Morales, DR, Jackson, C, Lipworth, BJ, Donnan, PT & Guthrie, B 2014,

'Adverse respiratory effect of acute beta-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials' CHEST, vol. 145, no. 4, pp. 779-786. DOI:
10.1378/chest.13-1235

Research output: Contribution To Journal



Guthrie, B & Morales, DR 2014,

'What happens when pay for performance stops? no evidence of serious harm so far, but future changes need evaluation' BMJ, vol. 348, g1413. DOI:
10.1136/bmj.g1413

Research output: Contribution To Journal



Grant, AM, Guthrie, B & Dreischulte, T 2014,

'Developing a complex intervention to improve prescribing safety in primary care: mixed methods feasibility and optimisation pilot study' BMJ Open, vol. 4, no. 1, e004153. DOI:
10.1136/bmjopen-2013-004153

Research output: Contribution To Journal



Marwick, CA, Guthrie, B, Pringle, JE, Mc Leod, SR, Evans, JM & Davey, PG 2014,

'Identifying which septic patients have increased mortality risk using severity scores: a cohort study' BMC Anesthesiology, vol. 14, no. 1, 1. DOI:
10.1186/1471-2253-14-1

Research output: Contribution To Journal



Simpson, RJ, Mc Lean, G, Guthrie, B, Mair, F & Mercer, SW 2014,

'Physical and mental health comorbidity is common in people with multiple sclerosis: nationally representative cross-sectional population database analysis' BMC Neurology, vol. 14, pp. 128. DOI:
10.1186/1471-2377-14-128

Research output: Contribution To Journal



Smith, DJ, Martin, D, Mc Lean, G, Langan, J, Guthrie, B & Mercer, SW 2013,

'Multimorbidity in bipolar disorder and undertreatment of cardiovascular disease: a cross sectional study' BMC Medicine, vol. 11, 263. DOI:
10.1186/1741-7015-11-263

Research output: Contribution To Journal



Guthrie, B, Clark, SA, Reynish, EL, Mc Cowan, C & Morales, DR 2013,

'Differential impact of two risk communications on antipsychotic prescribing to people with dementia in Scotland: segmented regression time series analysis 2001-2011' PLo S ONE, vol. 8, no. 7, pp. e68976. DOI:
10.1371/journal.pone.0068976

Research output: Contribution To Journal



Mathieson, L, Severn, A & Guthrie, B 2013,

'Monitoring and adverse events in relation to ACE inhibitor/angiotensin receptor blocker initiation in people with diabetes in general practice: a population database study' Scottish Medical Journal, vol. 58, no. 2, pp. 69-76. DOI:
10.1177/0036933013482634

Research output: Contribution To Journal



Smith, DJ, Langan, J, Mc Lean, G, Guthrie, B & Mercer, SW 2013,

'Schizophrenia is associated with excess multiple physical-health comorbidities but low levels of recorded cardiovascular disease in primary care: cross-sectional study' BMJ Open, vol. 3, no. 4, e002808. DOI:
10.1136/bmjopen-2013-002808

Research output: Contribution To Journal



Duffy, MA, Hernandez-Santiago, V, Orange, G, Davey, PG & Guthrie, B 2013,

'Trimethoprim prescription and subsequent resistance in childhood urinary infection: multilevel modelling analysis' British Journal of General Practice, vol. 63, no. 609, pp. 238-43. DOI:
10.3399/bjgp13X665198

Research output: Contribution To Journal



Payne, RA, Abel, GA, Guthrie, B & Mercer, SW 2013,

'The effect of physical multimorbidity, mental health conditions and socioeconomic deprivation on unplanned admissions to hospital: a retrospective cohort study' CMAJ, vol. 185, no. 5, pp. E221-E228. DOI:
10.1503/cmaj.121349

Research output: Contribution To Journal



Morales, DR, Jackson, C, Fielding, S & Guthrie, B 2013,

'Long-acting β-agonist prescribing in people with asthma in primary care' Thorax, vol. 68, no. 2, pp. 192-194. DOI:
10.1136/thoraxjnl-2012-202071

Research output: Contribution To Journal



Mc Cowan, C, Magin, P, Clark, S & Guthrie, B 2013,

'An observational study of psychotropic drug use and initiation in older patients resident in their own home or in care' Age and Ageing, vol. 42, no. 1, pp. 51-56. DOI:
10.1093/ageing/afs117

Research output: Contribution To Journal



Hughes, LD, Mc Murdo, MET & Guthrie, B 2013,

'Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity' Age and Ageing, vol. 42, no. 1, pp. 62-69. DOI:
10.1093/ageing/afs100

Research output: Contribution To Journal



Grant, A, Treweek, S, Dreischulte, T, Foy, R & Guthrie, B 2013,

'Process evaluations for cluster-randomised trials of complex interventions: a proposed framework for design and reporting' Trials, vol. 14, 15. DOI:
10.1186/1745-6215-14-15

Research output: Contribution To Journal



Saunders, C, Byrne, CD, Guthrie, B, Lindsay, RS, Mcknight, JA, Philip, S, Sattar, N, Walker, JJ, Wild, SH, Brady, I, Chalmers, J, Colhoun, H, Cunningham, S, Elder, R, Emslie-Smith, A, Fischbacher, C, Govan, L, Jones, N, Leese, G, Levine, D, Livingstone, S, Looker, H, Mc Alpine, R, Morris, A, Pearson, D & Petrie, J 2013,

'External validity of randomized controlled trials of glycaemic control and vascular disease: how representative are participants?' Diabetic Medicine, vol. 30, no. 3, pp. 300-308. DOI:
10.1111/dme.12047

Research output: Contribution To Journal



Smith, DJ, Langan, J, Mc Lean, G, Mercer, SW & Guthrie, B 2013,

'Schizophrenia is associated with excess multiple physical-health comorbidities but low levels of recorded cardiovascular disease in primary care: cross-sectional study' BMJ Open, vol. 3, no. 4. DOI:
10.1136/bmjopen-2013-002808

Research output: Contribution To Journal



Lawson, KD, Mercer, SW, Wyke, S, Grieve, E, Guthrie, B, Watt, GCM & Fenwick, EAE 2013,

'Double trouble: the impact of multimorbidity and deprivation on preference-weighted health related quality of life a cross sectional analysis of the Scottish Health Survey' International Journal for Equity in Health, vol. 12, no. 1. DOI:
10.1186/1475-9276-12-67

Research output: Contribution To Journal



View full profile on research portal