Bruce Guthrie

+44 (0)1382 383740
Head of Population Health Sciences Division, Professor of Primary Care Medicine and Honorary Consultant NHS Fife

Biography

Professor Guthrie is currently Professor of Primary Care Medicine at the University of Dundee Medical School where he leads the Quality, Safety and Informatics Research Group, which conducts applied research to translate basic and clinical research into effective and reliable clinical practice. He was previously a Medical Research Council Health Services Research Fellow at University of Edinburgh, an National Institute for Health Research post-doctoral research fellow at University of Dundee, and a 2006/7 Commonwealth Fund Harkness Fellow in Healthcare Policy at University of California San Francisco where he was also a Visiting Professor in 2010. His main research interests are the quality and safety of healthcare, particularly in primary care and currently focused on prescribing and the organisation of healthcare. Professor Guthrie is a mixed methods researcher and collaborate with researchers from a wide range of disciplines and institutions. He regularly reviews for various grant-making bodies and journals, contribute to undergraduate and postgraduate medical teaching, and supervise and examine MSc and PhD students in Dundee and other universities.

As well as conducting research, Professor Guthrie practices clinically in a general practice in Cardenden in NHS Fife, and is a member of a number of National Health Service advisory bodies. In 2014, he was appointed the Scottish Primary Care Research Champion by Scottish Government Chief Scientist Office, and was appointed by NICE to chair the guideline development group for the NICE Clinical Guideline on Multimorbidity.

Research

Chief Investigator

Guthrie B, Morales D, Thompson A, Donnan P, Payne K. Accounting for multimorbidity, competing risk and direct treatment disutility in risk prediction tools and model-based cost-effectiveness analysis for the primary prevention of cardiovascular disease and osteoporotic fracture. NIHR HS&DR Programme Sep 2016 to Aug 2019. £684,393

Guthrie B, Donnan P, Grant S, Mellon N, Dreischulte T. Enhanced Medication Summaries to reduce high-risk prescribing in people with polypharmacy in primary care: a cluster randomised trial. Chief Scientist Office Oct 2015 to Jan 2018. £224,992

Guthrie B, Davey P, Clarkson J, Marwick S. Improvement Science PhD Programme Award. Health Foundation Oct 2013 to Jan 2018. £278,872

Guthrie B, Rees C, Dowell J. UK Clinical Aptitude Test (UKCAT) Research Data Management. UKCAT Consortium Apr 2017 to Mar 2019. Extension£91,339

Fellowship supervisor or mentor

Hernandez Santiago V, Guthrie B, Davey PG, Marwick CA. A multilevel analysis of the impact of changes in antimicrobial prescribing on antimicrobial resistance. Chief Scientist Office Clinical Academic Fellowship for Dr Virginia Hernandez Santiago. Jan 2013 to Dec 2017. £232,847

Mills S, Guthrie B, Smith BH, Buchanan D. Use of unscheduled care in the last year of life by people who die from cancer. Chief Scientist Office Clinical Academic Fellowship for Dr Sarah Mills. Nov 2017 to Oct 2020. £150,000

Co-applicant

Marwick C, Hughes C, Francis J, Lorencatto F, Donnan P, Grant S, Guthrie B. Understanding and improving antimicrobial prescribing in care homes: a multidisciplinary approach. ESRC Oct 2017 to Sep 2021. £928,988

Grant S, Mesman J, Guthrie B. Improving the safety of inter-professional collaboration in an Acute Medical Unit: An examination of the feasibility and implementation of video reflexive ethnography in UK healthcare. Tenovus Oct 2017 to Sep 2018. £57,430

Avery A, Elliott R, Rodgers S, Ashcroft D, van Staa T, Peek N, Morales D, Guthrie B, Payne K, Armstrong S, Waring J, Sheikh A, Keers R, Bassi M, Chuter. Avoiding patient harm through the application of prescribing safety indicators in English general practices (acronym: PRoTeCT). NIHR Programme Grant Nov 2016 to May 20120. £2,430,000 (Dundee share ~£100,000).

Cvoro V, Wardlaw J, MacLullich A, Reynish E, Donnan PT, Guthrie B. Associations between brain Computed Tomography (CT) abnormalities and delirium: a study in 3000 older emergency medical patients. Dunhill Medical Trust 2017 to 2020. £185,751

Reynish E, Bowes A, Rutherford A, Donnan PT, Guthrie B.Understanding the outcomes of people with cognitive impairment and/or dementia admitted to the general hospital. NIHR Health Services and Delivery Research Programme. Jun 2015 to May 2017. £290,306.

Salisbury C, Hollinghurst S, Mercer S, Bower P, Guthrie B, Brookes S, Heawood A, Rafi I, Mann C, Gjini A. Improving the management of patients with multimorbidity in general practice. NIHR Health Services and Delivery Research Programme. Jan 2014 to Jun 2017. £1,890,000.

Renfrew M (CI), Guthrie B (coapplicant) and others. Scottish Improvement Science Research, Development And Knowledge Translation Collaborating Centre (SISCC). Chief Scientist Office, Scottish Funding Council, NHS Health Improvement Scotland, The Health Foundation. June 2014 to May 2019. £3,500,000.

PhD supervision

Mayada Al-Ghamdi. Unscheduled Care in NHS Scotland. Started 2017, ongoing.

Alpana Mair. Patients, carers clinicians and interprofessional roles in medication review and impact on adherence; an ethnographic study across different care settingsStarted 2016, ongoing.

Sean Macbride-Stewart. Measuring and improving primary care prescribing quality and safety using routine data. Started 2014, ongoing.

Xinyu Zhang. Measuring the safety of commonly prescribed drugs. Started 2013, ongoing.

Virginia Hernandez Santiago. A multilevel analysis of the impact of changes in antimicrobial prescribing on antimicrobial resistance. Ongoing.

Daniel Morales. Measuring the risk of ?-blocker and NSAID prescribing in asthma. Completed 2015.

Debbie Baldie. What scope is there to improve the use of patient experience feedback data for quality improvement in primary care? Completed 2016.

Anne Duguid. Managed clinical and care networks (MCNs) and work: an ethnographic study for non-prioritised clinical conditions in NHS Scotland. Completed 2012.

Charis Marwick. Design, implementation and primary evaluation of a complex intervention to improve the management of sepsis in general hospital wards. Completed 2011.

Heather Milne. Linking professional organisations of health care to patients’ perceptions and experiences of chronic illness. A discussion of health services for type 2 diabetes in Scottish primary care. Completed 2010.

Faranak Ansari. Evaluation and management of hospital antibiotic use. Completed 2010.

Group members

  • Dr. Daniel R Morales
  • Dr. Alison Hinds
  • Dr. Kim Stringer
  • Mrs. Marie C Pitkethly
  • Miss Xinyu Zhang
  • Mr. Sean P D MacBride-Stewart
  • Ms. Shona Livingstone

Lectures and conferences

December 2017. Menarini Foundation/European Respiratory Society “Multimorbidity: complexity of patients with multiple chronic diseases”, Rome. NICE Guidelines for multimorbidity. Invited presentation.

November 2017. European Medicines Agency Impact of Pharmacovigilance Information Day, London. Impact of regulatory risk communication on public health outcomes – challenges and opportunities. Invited presentation.

November 2017. North American Primary Care Research Group Annual Conference, Montreal. Applicability of clinical trial evidence to real-world populations: systematic review.

November 2017. European Drug Utilisation Group Annual Conference, Glasgow. Reducing high-risk prescribing and optimising prescribing in people with polypharmacy. Invited presentation.

October 2017. Royal College of General Practitioners Annual Conference, Liverpool. RCGP Research Paper of the Year Winners’ Enclosure: Safer prescribing – a trial of education, informatics and financial incentives. Invited presentation.

October 2017. Royal College of General Practitioners Fulton Lecture, Glasgow. Prescribing safety in a world of multimorbidity. Invited presentation.

June 2017. Chinese University of Hong Kong, Distinguished Scholar Programme. How can we better manage multimorbidity and polypharmacy? Invited Presentation.

June 2017. Chinese University of Hong Kong, Distinguished Scholar Programme. Improving prescribing safety in primary and ambulatory care. Invited Presentation.

March 2017. Academy of Medical Sciences Addressing the Global Challenge of Multimorbidity: Lessons from BRICS countries conference, London. Delivering health services for patients with multimorbidity, an introductory perspective from the UK. Invited presentation.

March 2017. World Kidney Day Conference, Alberta, Canada. Multimorbidity – strategies to improve prescribing in primary care. Invited keynote.

March 2017. City-wide rounds, Alberta, Canada. Multimorbidity – strategies to improve prescribing in primary care. Invited presentation.

February 2017. NHS Scotland Cluster-Quality Leads national meeting, Glasgow. Quality prescribing. Invited presentation.

December 2016. National Patient Safety Conference, Dublin. Improving safety for people with multimorbidity in primary care. Invited keynote.

November 2016. National Institute for Health Research Complex Needs scoping workshop, London. Research recommendations from the NICE multimorbidity guideline. Invited presentation.

October 2016. Royal College of General Practitioners Annual Conference, Harrogate. Whose illness is it anyway? The new NICE guidance on multimorbidity. Invited plenary.

October 2016. Irish Gerontological Society Annual Conference, Killarney. Multimorbidity and NICE Guidelines. Invited keynote.

August 2016. Farr Institute/International Population Data Linkage Network conference, Swansea. Improving primary care prescribing safety using routine data for intervention and evaluation: four trials in 500+ practices. Plenary presentation.

October 2015. Guidelines International Network Conference, Amsterdam. Multimorbidity in guidelines. Invited plenary.

July 2015. Society for Academic Primary Care Conference, Oxford. Multimorbidity: new paradigm of the emperor’s new clothes? Invited keynote.

July 2015. University of Cambridge. Prescribing safety in a world of multimorbidity. Invited seminar.

June 2015. Scottish Intercollegiate Guidelines Network Strategy Group, Edinburgh. Multimorbidity in guidelines. Invited presentation.

June 2015. NICE Board Strategy Day, London. Multimorbidity in guidelines. Invited presentation.

June 2015. Scottish Intercollegiate Guidelines Network/Health Improvement Scotland, Edinburgh. The challenges of making guidelines in a world of multimorbidity. Invited presentation.

May 2015. NICE Technical Workshop, Manchester. Multimorbidity in guidelines. Invited presentation.

June 2014. DECIDE conference: Better clinical guidelines, better healthcare decisions, Edinburgh. How useful are evidence-based guidelines to primary care? Invited keynote.

October 2013. REPOSI International Seminar on Multimorbidity, Milan. New approaches for clinical trials and guidelines. Invited presentation.

July 2013. Australian Primary Health Care Research Institute Visiting Fellowship. Multiple invited presentations:

· Australian Commission on Safety and Quality and Healthcare, Sydney Australia. Multimorbidity and polypharmacy: emerging challenges in primary care.

· Royal Australian College of General Practitioners workshop, Primary Health Care Research Conference, Sydney Australia. Resourcing practices to manage patients with complex multimorbidity.

· Patient Safety Collaboratives Symposium, Primary Health Care Research Conference, Sydney Australia. The Scottish Patient Safety Programme in Primary Care.

· Multimorbidity Symposium, Primary Health Care Research Conference, Sydney Australia. The rising tide of multimorbidity and polypharmacy.

· University of Melbourne. Use of routinely collected data for research in general practice and primary care.

· Primary Health Care Research Information Service, Flinders University, Adelaide. Allies in research, policy and practice: what can we do about multimorbidity?

· Adelaide University. Multimorbidity and polypharmacy: emerging challenges in primary care.

· Centre for Remote Health, Alice Springs. Multimorbidity and polypharmacy: emerging challenges in primary care.

May 2013. Scottish Government Health Directorates Multimorbidity Workshop. Multimorbidity in Scotland. Invited presentation.

March 2013. University of Zurich. Multimorbidity and polypharmacy in UK primary care: from epidemiology to interventions. Invited presentation.

February 2013. Multimorbidity and the Last Phase of Life conference, Edinburgh. Making guidelines work for people with multimorbidity. Invited presentation.

February 2013. National Institute for Health Research Primary Care Themed call, London. The NIHR Health Services and Delivery Research Programme. Invited presentation.

October 2012. Scottish Government Health Directorates Quality Strategy Effective Delivery Group, Edinburgh. Multimorbidity in Scotland. Invited presentation.

March 2012. Scottish Safety Improvement in Primary Care Programme. Using data to improve reliability of care. Invited presentation.

May 2011. Commonwealth Fund Policy Forum, Washington DC. Improving Patient Safety Across An Entire National Health System: The Scottish Patient Safety Programme and the Safety Improvement in Primary Care Collaborative. Invited presentation.

May 2011. Agency for Healthcare Research and Quality, Washington DC. Improving patient safety in primary care. Invited presentation.

April 2011. Agency for Healthcare Research and Quality/Commonwealth Fund/American Academy of Family Practitioners workshop on International Learning on Increasing the Value and Effectiveness of Primary Care. Quality and Safety in UK Primary Care. Invited presentation.

Teaching

Although research is the focus of my academic activity, I maintain a regular teaching commitment at both undergraduate and postgraduate level. I completed the University of Dundee Learning, Teaching and Assessment in Higher Education module in 2010 and am an Associate Member of the Higher Education Academy.

Undergraduate

  • 4th year project and summer studentship supervision
  • Tutor on various primary care led areas of the undergraduate course

Postgraduate

  • 2006-2009 External Examiner, MSc in International Primary Healthcare, University College London
  • 2007 to date, PhD External Examiner on a number of theses in Scotland, England and Eire
  • 1999-date designed and run NHS Education Scotland Continuing Professional Development courses on Evidence Based Medicine, Medicine and the Internet, and Critical Reading and Thinking
  • 1999-2005 designed and ran Evidence Based Medicine and Searching for Information/Knowledge Management teaching for GP Registrar groups in three Scottish Regions

Publications

2017

Grant S, Guthrie B. Efficiency and thoroughness trade-offs in high-volume organisational routines: an ethnographic study of prescribing safety in primary care. BMJ Quality and Safety 2017 Published online 10.1136/bmjqs-2017-006917

Baldie D, Guthrie B, Entwistle V, Kroll T. Exploring the impact and use of patients' feedback about their care experiences in general practice settings - a realist synthesis. Family Practice 2017 Online early doi:10.1093/fampra/cmx067

Toma M, Davey P, Marwick C, Guthrie B. A framework for ensuring a balanced accounting of the impact of antimicrobial stewardship interventions. Journal of Antimicrobial Chemotherapy 2017 online early doi:10.1093/jac/dkx312

Tonelli M, Wiebe N, Straus S, Fortin M, Guthrie B, James M, Klarenbach S, Tam-Tham H, Lewanczuk R, Manns B, Quan H, Ronksley P, Sargious P, Hemmelgarn B. Multimorbidity, dementia and health care in older people: a population-based cohort study. CMAJ Open 2017 DOI:10.9778/cmajo.20170052

Toma M, Dreischulte T, Gray NM, Campbell D, Guthrie B. Balancing measures or a balanced accounting of improvement impact: a qualitative analysis of individual and focus group interviews with improvement experts in Scotland. BMJ Quality and Safety 2017 online early http://qualitysafety.bmj.com/content/early/2017/10/21/bmjqs-2017-006554.full

Dreischulte T, Grant A, Hapca A, Guthrie B. Process evaluation of the Data-driven Quality Improvement in Primary Care (DQIP) trial: Quantitative examination of variation between practices in recruitment, implementation and effectiveness. BMJ Open 2017;8:1

Neilly M, Guthrie B, Hernandez-Santiago V, Vadiveloo T, Donnan P, Marwick C. Has primary care antimicrobial use really been increasing? Comparison of changes in different prescribing measures for a complete geographic population 1995-2014. Journal of Antimicrobial Chemotherapy 2017; 72(10):2921-2930

Stokes J, Man M-S, Guthrie B, Mercer SW, Salisbury C, Bower P. The Foundations Framework for developing and reporting new models of care for multimorbidity. Annals of Family Medicine 2017:15(6): 570-577.

Guthrie B, Gillies J, Calderwood C, Smith G, Mercer SW. Developing middle-ground research to support primary care transformation. British Journal of General Practice 2017:67;498-499.

Marwick CA, Davey PG, Guthrie B. Hospital antimicrobial stewardship: the way forward. The Lancet Infectious Diseases 17(11): 1119-1120

Zhang X, Donnan P, Bell S, Guthrie B. Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis. BMC Nephrology 2017 18(1): 256

Weatherburn C, Guthrie B, Mercer SW, Morales D. Comorbidities in adults with asthma: population-based cross-sectional analysis of 1.4 million adults in Scotland. Clinical and Experimental Allergy 2017 47(10): 1246-1252

Thomson A, Guthrie B, Payne K. Using the 'pay-off time' in decision-analytic models: a case study for using statins in primary prevention. Medical Decision Making 2017: 37(7): 759–769

Reynish E, Hapca S, De Sousa N, Cvoro V, Donnan P, Guthrie B. Epidemiology and outcomes of people with dementia, delirium and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions. BMC Medicine 2017: 15:140

McLean G, Hindle J, Guthrie B, Mercer SW. Co-morbidity and polypharmacy in Parkinson's Disease: insights from a large Scottish primary care database. BMC Neurology 2017 17(1): 126

Bosco BF, Mclean G, Mair FS, Roger VL, Guthrie B, Mercer SW. Multimorbidity and polypharmacy in heart failure: a cross-sectional study of 1,421,756 patients in primary care. BJGP 2017: 67(658): e314-e20

MacBride-Stewart S, Marwick C, Houston N, Watt I, Patton A, Guthrie B. Education, feedback and financial incentives to improve primary care prescribing safety: segmented regression interrupted time-series analysis on the impact of a system-wide phase 4 complex intervention. BJGP 2017; 67(658): e352-e60.

Guthrie B, Thompson A, Dumbreck S, Flynn A, Alderson P, Nairn M, Treweek S, Payne K. Better guidelines for better care: accounting for multimorbidity in clinical guidelines – structured examination of exemplar guidelines and health economic modelling. Health Services and Delivery Research 2017:5;16

Chetty U, Mclean G, Morrison D, Agur K, Guthrie B, Mercer SW. COPD and Comorbidities: A Cross- Sectional Analysis of 1.2 Million Patients from a Nationally Representative Dataset in Scotland. BJGP 2017:67;e321-e328

Grant M, Checkland K, Bowie P, Guthrie B. The role of informal dimensions of safety in high-volume organisational routines: an ethnographic study of test results handling in UK general practice. Implementation Science 2017:12(1);56

Blane D, McKay D, Guthrie B, Mercer SW. Smoking cessation interventions for patients with coronary heart disease and comorbidities: An observational cross-sectional study in primary care. BJGP 2017:67;e118-e129.

Grant A, Dreischulte T, GuthrieB. Process evaluation of the Data-driven Quality Improvement in Primary Care (DQIP) trial: Case-study evaluation of adoption and maintenance of a complex intervention to reduce high-risk primary care prescribing. BMJ Open 2017;7(3)

Morales D, Guthrie B. Off-label antidepressant prescribing and the extrapolation of evidence. BMJ 2017;356:j849

Clague F, Mercer SW, McLean G, Reynish E, Guthrie B. Co-morbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data. Age and Ageing 2017:46(1);33-39.

Morales D, Lipworth B, Donnan P, Jackson C, Guthrie B. Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population based nested case control study. BMC Medicine 2017:15;18

Weatherburn C, Heath C, Mercer SW, Guthrie B. Physical and mental health comorbidities of epilepsy: population-based cross-sectional analysis of 1.5 million people in Scotland. Seizure 2017:45;125-131

2016

Grant A, Dreischulte T, Guthrie B. Process evaluation of the Data-driven Quality Improvement in Primary Care (DQIP) trial: Active and less active ingredients of a multi-component complex intervention to reduce high-risk primary care prescribing. Implementation Science 2016:12(1);4

Farmer C, Fenu E, O’Flynn N, Guthrie B. Multimorbidity: clinical assessment and management: summary of updated NICE guidance. BMJ 2016; 354:i4843

Guthrie B, Kavanagh K, Robertson C, Barnett K, Treweek S, Petrie D, Ritchie L, Bennie M. Data feedback and behavioural change intervention to improve primary care prescribing safety (EFIPPS): multicentre, three arm, cluster randomised controlled trial. BMJ 2016; 354: i4079

Morales DR, Dreischulte T, Lipworth BJ, Donnan PT, Jackson C, Guthrie B. Beta-blocker eye drops in asthma: meta-analysis of clinical trials and observational study. British Journal of Clinical Pharmacology 2016: 82(3):814-22.

Roland M, Guthrie B. The Quality and Outcomes Framework: how did QOF come about and what have we learned? BMJ Jul 2016 354: i4060

Ruscitto A, Mercer SW, Morales D, Guthrie B. Accounting for multimorbidity in pay-for-performance: a modelling study using United Kingdom Quality and Outcomes Framework data. BJGP 2016:66;e561-e567

Mercer SW, Fitzpatrick B, Guthrie B, Fenwick E, Grieve E, Lawson K, Boyer V, McConnachie A, Lloyd S, O’Brien R, Watt GCM, Wyke S. The Care Plus study- a whole system intervention to improve quality of life of primary care patients with multimorbidity in areas of high socioeconomic deprivation: cluster randomised controlled trial. BMC Medicine 2016:14(1):1-10

Mercer SW, O'Brien R, Fitzpatrick B, Higgins M, Guthrie B, Watt G, Wyke S. The development and optimisation of a primary care-based whole system complex intervention (CARE Plus) for patients with multimorbidity living in areas of high socioeconomic deprivation. Chronic Illness 2016; 12(3):165-81

Kontopantelis E, Springate D, Ashcroft D, Valderas JM, van der Veer S, Reeves D, Guthrie B, Doran T. Determinants of exemption from the UK’s primary care pay-for-performance programme and survival outcomes: a retrospective cohort study. BMJ Quality and Safety 2016; 25:9 657-670

Mann C, Shaw A, Guthrie B, Wye L, Man M-S, Hollinghurst S, Brookes S, Bower P, Mercer S, Salisbury S. Process evaluation of a cluster randomised controlled trial to improve management of multi-morbidity in general practice (The 3D study) – protocol paper. BMJ Open 2016;6(5): e011260

Man M-S, Chaplin K, Mann C, Bower P, Brookes S, Fitzpatrick B, Guthrie B, Shaw A, Hollinghurst S, Mercer S, Rafi I, Thorn J, Salisbury C. Improving the management of multimorbidity in general practice: Protocol of a cluster randomised controlled trial (The 3D Study). BMJ Open 2016:6(4): e011261.

Agur K, McLean G, Hunt K, Guthrie B, Mercer S. How does gender influence multimorbidity? Secondary analysis of a large nationally representative dataset. International Journal of Environmental Research and Public Health 2016;13(4):391

Dreischulte T, Donnan P, Hapca A, Grant A, McCowan C, Guthrie B. Safer prescribing: a trial of incentives, informatics and education. New England Journal of Medicine 2016:374 1053-1064

Thomson A, Guthrie B, Payne K. Do pills have no ills? Capturing the impact of direct treatment disutility. Pharmacoeconomics 2016:34:333–336

Steven K, Dowell J, Jackson C, Guthrie B. Fair access to medicine? Retrospective analysis of UK medical schools’ application data 2009-2012 using four measures of socioeconomic status. BMC Medical Education 2016:16(1):1-10.

Grant S, Mesman J, Guthrie B. Spatio-temporal elements of articulation work in the achievement of repeat prescribing safety in UK general practice. Sociology of Health and Illness 2016; 38(2);306-324

Hughes LD, Cochrane L, McMcurdo MET, Guthrie B. Psychoactive prescribing for older people: what difference does 15 years make? International Journal of Geriatric Psychiatry 2016:31;49-57

2015

McLean G, Guthrie B, Mercer SE, Watt GCM. General practice funding underpins the persistence of the inverse care law: cross-sectional analysis of multimorbidity, consultation rates and funding in Scottish general practice. BJGP 2015:65:e799-e805.

Guthrie B, Donnan PT, Murphy D, Makubate B, Dreischulte T. Bad apples or spoiled barrels? Multilevel modelling analysis of variation in high-risk prescribing between general practitioners and between the practices they work in. BMJ Open 2015:15:11

Heath C, Mercer SW, Guthrie B. Vascular co-morbidities in younger people with dementia: a cross-sectional population based study of 616,245 middle-aged people in Scotland. Journal of Neurology, Neurosurgery and Psychiatry 2015: 86(9):959-64

Hernandez Santiago V, Marwick C, Patton A, Davey PG, Donnan PT, Guthrie B. Time series analysis of the impact of an intervention to improve prescribing of antimicrobials related to Clostridium difficile infection in Tayside, Scotland. Journal of Antimicrobial Chemotherapy 2015:70;2397-2404

Dowell J, Norbury M, Steven K, Guthrie B. Widening access to medicine may improve general practitioner recruitment in deprived and rural communities. BMC Medical Education 2015:15(1):165.

Tonelli M, Wiebe N, Guthrie B, James MT, Quan H, Fortin M, Klarenbach SW, Sargious P, Straous S, Lewanczuk R, Ronksley P Manns BJ, Hemmelgarn BR. Comorbidity as a driver of adverse outcomes in people with chronic kidney disease: a cohort study. Kidney International 2015;88:859-866.

Cooper S, McLean G, Guthrie B, McConnachie A, Mercer S, Sullivan F, Morrison J. Physical and mental health comorbidity in adults with intellectual disabilities: population-based cross-sectional analysis. BMC Family Practice 2015: 16:110

Dreischulte T, Morales D, Bell S, Guthrie B. Combined use of NSAIDs with diuretics and renin-angiotensin system inhibitors and the risk of acute kidney injury in the community. Kidney International 2015; 88, 396–403

Morales D, Guthrie B, Lipworth B, Jackson C, Donnan PT, Santiago VH. Aspirin intolerant asthma: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity. Allergy 2015:70;828-835

Guthrie B, Makubate B, Hernandez-Santiago V, Dreischulte TD. The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995-2010. BMC Medicine 2015;13:74.

Tonelli M, Wiebe N, Martin F, Guthrie B, Hemmelgarn BR, James MT, Klarenbach SW, Lewanczuk R, Manns BJ, Ronksley P, Sargious P, Straus S, Quan H and For the Alberta Kidney Disease Network. Methods for identifying 27 chronic conditions: Application to administrative data. BMC Med Inform Decis Mak 2015;15:31.

Dumbreck S, Flynn A, Nairn M, Wilson M, Treweek S, Mercer SW, Alderson P, Thompson A, Payne K, Guthrie B. Systematic examination of drug-disease and drug-drug interactions from following recommendations in 12 UK national clinical guidelines. BMJ 2015;350:h949

Ruscitto A, Smith B, Guthrie B. Changes in opioid and other analgesic use 1995-2010: repeated cross-sectional analysis of dispensed prescribing for a large geographical population in Scotland. European Journal of Pain 2015;19(1):59-66

Grant S, Ring A, Mclean G, Guthrie B, Gabbay M, Mair F, Watt G, Heaney D, O’Donnell, C. Soft governance, restratification and the 2004 general medical services contract: the case of UK primary care organisations and general practice teams. Sociology of Health and Illness 2015 37(1);30-51

Wallace E, Salisbury C, Guthrie B, Lewis C, Fahey T, Smith SM. Clinical review: managing patients with multimorbidity in general practice. BMJ 2015;350:h476