Miss Beatrix Elsberger is a SCREDS Clinical Lecturer in Surgical Oncology at the University of Dundee and Honorary Specialty Registrar (StR8) in General Surgery in Ninewells Hospital, NHS Tayside.
She graduated in Medicine from the University of Regensburg, Germany, in 2000. After her junior doctor years in England and New Zealand she undertook her postgraduate basic surgical training in Edinburgh and specialty registrar training in Dundee. Since her sub-speciality interest is in Breast Surgery she additionally completed a Breast Fellowship in Melbourne, Australia, in 2016/17.
She has been awarded two higher research degrees (MD 2007/PhD 2011) additionally to her FRCSEd Gen in 2016.
Miss Beatrix Elsberger’s main research interests are in clinical and translational research in breast cancer. Her PhD in Molecular Pathology at the University of Glasgow was investigating the role of Src kinase family in breast cancer. By assessing gene and protein expression of Src kinase family members in invasive breast specimens and investigating their clinical significance, a clear relation to disease recurrence and worsening survival was demonstrated using fresh frozen tissue and tissue microarrays in conjunction with in vitro cell line studies. The necessity of identifying correct biomarkers in breast cancer patients, who most likely respond to phase II clinically trialled Src kinase inhibitors, was highlighted during this project.
Alongside her surgical training commitments and teaching activities, Miss Elsberger is continuing with her research interest. She is local PI for the UK and AUS/NZ wide breast surgical trial POSNOC. Collaborating locally with Clinical Genetics, to examine the clinical management of BRCA1/2 and TP53 mutation carriers, and collaborating with Southampton and Liverpool HPB surgeons, to raise profile for meaningful surgical hepatic interventions and better clinical outcome by selecting certain metastatic breast cancer patients, demonstrates the spectrum of her engagement into different areas of breast cancer research.
Miss Elsberger has also research collaboration links with Professor Valerie Brunton at the Cancer Research Centre in Edinburgh. A grant from the Academy of Medical Sciences permitted investigations into matched pre-and post HER2 therapy breast cancer tissue samples, collected and stored under the remit of the Tayside Tissue Bank. This tissue work, looking at certain antibodies/biomarker expressions, supports the understanding of relevant pathways responsible of the development of resistance to HER2 targeted therapies in breast cancer.
Lectures and conferences
Feb 2014: College Research Symposium (University of Dundee), Crieff, Scotland
Nov 2013: Scottish National Breast Cancer Trials Meeting, Edinburgh
Nov 2013: Markers in Cancer, Brussels, Belgium
May 2013: Annual Associations of Breast Surgeons Conference, Manchester
May 2013: IMPAKT Translational breast cancer research conference, Brussels, Belgium
Feb 2013: College Research Symposium (University of Dundee), Crieff, Scotland
May 2010: ASGBI Conference, Liverpool
Dec 2009: San Antonio Breast Cancer Research Symposium, Texas, USA
Nov 2009: BASO/ABS and Cancer Genetics Group Joint Scientific Conference, London
Oct 2009: NCRI conference, Birmingham,
Sept 2009: ECCO 15/ESMO 34 Conference, Berlin, Germany
Sept 2009: European Conference of Pathology, Florence, Italy
Dec 2008: San Antonio Breast Cancer Research Symposium, Texas, USA
Jan 2014: Cell-free DNA workshop, NCRI, Manchester
Jan 2014: Experimental Cancer Medicines Centres Junior Investigator Network Group Workshop: Early phase in Clinical and Translational Trials, ECMC, Birmingham
Nov 2013: Markers in Cancer; Diagnostic Development Tutorial, EORTC/ASCO/NCI, Brussels, Belgium
Oct 2013: Development of postgraduate supervisors, University of Dundee
June 2013: Methods in Clinical Cancer Research, ECCO/ESSO/AACR/EORTC, Flims, Switzerland
May 2013: New Technical Advances in Translational Breast Cancer Research, ESMO, Brussels, Belgium
Feb 2013: Setting Research Objectives and Managing Research Projects, University of Dundee
Jan 2012: Good Clinical Practice training course- TASC Centre, NHS Tayside
2013- present: Breast Cancer and Breast Examination module 3rd year MBChB students (University of Dundee)
2013-2014: Honorary Clinical Tutor, University of Edinburgh: MSc supervisor (ESSQ breast surgery project)
2009-2013: Honorary Clinical Teacher; University of Glasgow: Lecturing BN students (University of Glasgow; Human Disease and Pathology Course) and BSc Students (University of Glasgow), in Cancer Studies, Cardiovascular Studies.
2008-2010: BSc student supervisor (undergraduate BmedScience course, University of Glasgow)
2008- present: ESSQ (Edinburgh Surgical Science Qualification) eTutor;
2007- present: Advanced Trauma Life Support (ATLS) Instructor (RCSEd)- 2 courses per year
Is there a role for surgical resections of hepatic breast cancer metastases? Elsberger B, Roxburgh S, Horgan PG. Hepatogastroenterology 2014- accepted for publication
Translational evidence on the role of Src kinase and activated Src kinase in invasive breast cancer,Elsberger B.- Critical Reviews in Oncology and Haematology 2014- in press
Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy?Elsberger B, Romsauerova A, Vinnicombe S, Whelehan P, Brown DC, Dewar J, Thompson AM, Evans A. EJSO 2013 Dec 4. [Epub ahead of print] PMID: 24332581
The relationship between lymphocyte subsets and clinico-pathological determinants of survival in patients with primary operable invasive ductal breast cancer. Mohammed ZM, Going JJ, Edwards J, Elsberger B, McMillan DC. Br J Cancer 2013;109(6):1676-84. PMID: 23982600
Identification of novel functional and spatial interaction between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signalling proteins, associated with prognostic outcome in estrogen positive breast cancer. Ohotski J, Edwards J, Elsberger B, Watson C, Orange C, Mallon E, Pyne S Pyne NJ. Int J Cancer 2013;132(3):605-16. PMID:22733311
The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer. Mohammed ZMA, Going JJ, Edwards J, Elsberger B, Doughty J, McMillan DC. Br J Cancer 2012;107(5):864-73. PMID: 22878371
Expression of the Sphingosine 1-phosphate receptor 4 and Sphingosine kinase 1 is associated with outcome of oestrogen receptor negative breast cancer patients. Ohotski J, Long JS, Orange C, Elsberger B, Mallon EA, Doughty J, Pyne S, Pyne NJ, Edwards J. Br J Cancer (2012);106(8):1453-9. PMID: 22460268
Comparison of observer and automated assessment for Ki-67 and their impact on outcome in primary operable invasive ductal breast cancer. Mohammed ZMA, McMillan DC, Elsberger B, Going JJ, Edwards J. Br J Cancer (2012);106(2):383-8. PMID: 22251968
Shorter disease specific survival of ER positive breast cancer patients with high cytoplasmic Src kinase expression after tamoxifen treatment. Elsberger B, Paravasthu DM, Tovey SM, Edwards J. J Cancer Res Clin Oncol. (2011);138(2):327-332. PMID: 22134837
Expression of hypoxia inducible factor-1 alpha in matched hormone naive and castrate resistant prostate cancer specimens. Elsberger B, Lankston L, Orange C, Underwood MA, Edwards J Cancer Biomark (2011);8(1):1-9. PMID:21896985
Presence of C-reactive protein correlated with progressive prostate cancer. Elsberger B, Lankston L, McMillan DC, Underwood MA, Edwards J. Prostate Cancer Prostatic Dis (2011);14(2):122-8. PMID:21358753
Is there an association with phosphorylation and dephosphorylation of Src kinase at tyrosine 530 and breast cancer patient disease-specific survival. Elsberger B, Tan BA, Mallon EA, Brunton VG, Edwards J. Br J Cancer (2010);103(12):1831-4. PMID: 21063412
Breast cancer patients’ clinical outcome measures are associated with Src kinase family member expression. Elsberger B, Fullerton R, Zino S, Mitchell TG, Brunton V, Shiels P, Edwards J. Br J Cancer (2010);103:899-909. PMID: 20717116
Is Src a viable target for treating solid tumours? (review) Elsberger B, Stewart B, Tartarov O and Edwards J. Current Cancer Drug Target J (2010);10(7):683-94. PMID: 20578988
Expressions of total and activated c-Src correlate differently with patient survival in ER and HER2 negative breast cancer patients. Implication for use of Src kinase inhibitors in triple negative patients? Elsberger B, Tan BA, Brown S, Mallon E, Tovey, S, Cooke TC, Brunton VG, Edwards J. Am J Path (2009);175(4):1389-97. PMID: 19762712
Is the biology of breast cancer changing? A study of hormone receptor status 1984-86 and 1996-1997. Brown SBF, Mallon EA, Edwards J, Campbell FM, McGlynn LM, Elsberger B and Cooke TG. Br J Cancer (2009);100(5): 807-10. PMID:19223901
Self-expanding Metallic Stent Insertion in the Proximal Colon. Elsberger B, Rourke K, Brush J, Glancy S, Collie M. Colorectal Dis (2008);10(2):194-6. PMID:17784867