Aidan Rose

Clinical Lecturer in Plastic Surgery (SCREDS)

Biography

Current positions:

SCREDS Clinical Lecturer in Plastic Surgery; University of Dundee

ST6 Plastic Surgery; Canniesburn Plastic Surgery Unit, Glasgow Royal Infirmary

Previous positions:

BScHons - Virology (2002): University of Edinburgh

MBChB (2005): University of Edinburgh

MRCSEd (2009): Royal College of Surgeons of Edinburgh

PhD (2016): University of Dundee. Supervisor: Prof Gareth J Inman. Thesis Title – The Role of Transforming Growth Factor-? Signalling in Human Cutaneous Squamous Cell Carcinoma

Research

I am interested in the role of TGF-? superfamily signalling in human cutaneous squamous cell carcinoma. I have continued post-doctoral academic training as a SCREDS Clinical lecturer under the supervision of Prof Gareth Inman. I have received funding from Tenovus Scotland (Small Research Grant), the Academy of Medical Sciences (Starter Grant for Clinical Lecturers) and Cancer Research UK (Post-doctoral Research Bursary for Clinical Trainees).

 

Lectures and conferences

I have presented work at the following national and international meetings:

  • Inactivation of TGF-? receptors in stem cells drives cutaneous squamous cell carcinoma

Rose AM, Cammareri P and Vincent DF et al.

BAPRAS Winter Meeting. London, Nov 2017. Presidents Prize Podium presentation.

  • Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

Rose AM et al.

Scottish Plastic Surgeons – Annual Meeting. Dunkeld, UK. Oct 2017. Podium presentation

  • Inactivation of TGF-? receptors in stem cells drives cutaneous squamous cell carcinoma

Rose AM, Cammareri P and Vincent DF et al.

Scottish Plastic Surgeons – Annual Meeting. Dunkeld, UK. Oct 2016. Podium presentation

  • Use of the Brigham and Women’s Hospital Tumour Staging for Cutaneous Squamous Cell Carcinoma (cSCC) to Safely Reduce the Economic Impact of Disease on Outpatient Services

Moinie A, Nicoll K, Schneider J, Jordan D, Rose AM and Naasan A

Scottish Plastic Surgeons – Annual Meeting. Dunkeld, UK. Oct 2016. Podium presentation

  • A reduction in endogenous transforming growth factor-? signalling independently predicts increased tumour depth in human cutaneous squamous cell carcinoma

Rose AM, Stephen C, Mitchell A, Rickaby W, Bray S, Evans AT, Proby CM, Leigh IM, Coates PJ and Inman GJ

World Congress on Cancers of the Skin – Biannual meeting. Vienna, Austria. Aug 2016. Poster presentation.

  • The role of TGF-? signalling in cutaneous squamous cell carcinoma

Rose AM, Cammareri P, Vincent D, Pourreyron C, Spender L Leigh IM, Proby CM, South AP Sansom O and Inman GJ

European Association of Plastic Surgeons – Annual meeting. Brussels, Belgium. May 2016.

Podium presentation.

 

  • Frequent loss of function mutations in TGFBR1 and TGFBR2 implicate hair follicle bulge stem cells as a cell of origin of cutaneous squamous cell carcinoma

Rose AM, Cammareri P, Vincent D, Pourreyron C, Spender L Leigh IM, Proby CM, South AP Sansom O and Inman GJ

European Plastic Surgery Research Council – Annual Meeting. Edinburgh, UK. May 2015.

Podium presentation.

World Congress on Cancers of the Skin. Edinburgh, UK. Sep 2015. Podium presentation.

  • Loss of TGF-? signalling and oncogenic BRAF or KRas activation in Lgr5+ve stem cells drives rapid cutaneous squamous carcinoma

Cammareri P, Rose AM and Vincent DF et al.

British Society of Investigative Dermatology. Southampton, UK. Apr 2015. Poster presentation

Scottish Society for Investigative Dermatology. Glasgow, UK. Apr 2014. Podium presentation

College of Medicine, Dentistry and Nursing Annual Symposium. University of Dundee, UK. Feb 2014. Poster presentation

  • TGF-? Signalling in Human Cutaneous Squamous Cell Carcinoma

Rose AM, Cammareri P, Vincent D, Pourreyron C, Spender L Leigh IM, Proby CM, South AP, Sansom O and Inman GJ

European Society of Plastic, Reconstructive and Aesthetic Surgery. Edinburgh, UK. Jun 2014.

Poster presentation.

  • Interpreting Metastatic Melanoma Tumour Burden in the Sentinel Lymph Node

Rose AM, Teo I, Carpenter F, Munnoch A, Hough M

European Society of Plastic, Reconstructive and Aesthetic Surgery. Edinburgh, UK. Jun 2014.

Poster presentation.

  • TGF-? Signalling in Human Cutaneous Squamous Cell Carcinoma – Aberrations Associated With Novel TGF-? Receptor Mutations

Rose AM, Pourreyron C, Purdie K, Harwood CA, Leigh IM, Proby CM, South AP and Inman GJ

Federation of American Societies For Experimental Biology. Colorado, United States. Jul 2013.

Poster presentation.

  • Prognostic Impact of Sentinel Node Tumour Burden in Cutaneous Melanoma

Rose AM, Teo I, Carpenter CVE, Hough M, Munnoch DA

5th International Symposium on Cancer & Metastasis. San Francisco, United States. May 2013.

Poster presentation.

  • Identifying the Sentinel Lymph Node in Cutaneous Melanoma – An Audit

Teo I, Rose AM, Carpenter CVE, Hough M, Munnoch DA

5th International Symposium on Cancer & Metastasis. San Francisco, United States. May 2013.

Poster presentation.

  • Do Histopathological Features in Malignant Melanoma Affect The Identification and Positivity Rates of The Sentinel Lymph Node?

Carpenter CVE, Rose AM, Teo I, Hough M, Munnoch DA

5th International Symposium on Cancer & Metastasis. San Francisco, United States. May 2013.

Poster presentation.

  • Does Site of Primary Malignant Melanoma Affect Sentinel Lymph Node Biopsy Success Rates and Overall Survival? A Review of 199 Cases

Teo I, Rose AM, Carpenter CVE, Hough M, Munnoch DA

5th International Symposium on Cancer & Metastasis. San Francisco, United States. May 2013.

Poster presentation.

  • Improving Documentation In The Plastic Surgery One-Stop Clinic

Teo I, Rose AM, Hough M

International Forum for Quality and Safety in Healthcare. London, UK. Apr 2013. Poster presentation.

British Association of Day Surgery (BADS). Leeds, UK. Jun 2011. Poster presentation

  • Cutaneous Squamous Cell Carcinoma and the RAS Controversy

McHugh A, Purdie K, Pourreyon C, Watt S, Saville M, Evans A, Rose AM, Leigh I, Harwood C, South A, Proby C

International Investigative Dermatology. Edinburgh, UK. May 2013. Poster presentation.

  • “The Plastic Surgery “One-Stop” Service”

Teo I, Rose AM, Hough M

Association of Surgeons of Great Britain and Ireland (ASGBI). Glasgow, UK. May 2013.

Poster presentation

Association of Surgeons in Training (ASit). Manchester, UK. Apr 2013.

Poster presentation

  • Prognostic Significance of the Melanoma Mitotic Rate

Rose AM, Hough M, Munnoch DA.

4th International Symposium on Cancer & Metastasis. New York, United States. May 2011.

Poster presentation.

BAPRAS Summer Meeting. Oxford, UK. Jul 2011. Podium “Bell” presentation.

Scottish Plastic Surgery Meeting. Dunkeld, UK. Oct 2011. Podium presentation.

  • Breast Reduction Surgery in a Day Surgery Unit: An Enhanced Recovery Program

Fowler J, McDonald C, Rose AM, Hough M

British Association of Day Surgery (BADS). Leeds, UK. Jun 2011. Poster presentation

  • A “One-Stop” Skin Cancer Service Using A Digital Referral System - An Audit

Rose AM, Hough M

British Association of Day Surgery (BADS). Leeds, UK. Jun 2011. Poster presentation

  • A Single Units Five Year Experience in Sentinel Lymph Node Biopsy

Rose AM, Hough M, Munnoch DA

Annual Audit Symposium - RCSEd. Edinburgh, UK. Mar 2011. Plenary podium presentation

  • Open Fractures of the Lower Limb

Rose AM, Wood E, Webb M

Audit Symposium - RCSEd. Edinburgh, UK. Mar 2011. Poster presentation.

  • Nerve Conduction Studies for Cubital Tunnel Syndrome

Anderton M, Rose AM, Shah F, Harvey I, Webb M

Scottish Plastic Surgery Meeting. Dunkeld, UK. Oct 2010. Podium presentation.

  • Adherence to National Burn Care Review Referral Criteria in a Paediatric Emergency Department

Rose AM, Davenport K, Evans N, Hassan Z, Falder S

British Burn Association (BBA). East Grinstead, Apr 2010. Podium presentation.

Egyptian Society of Plastic and Reconstructive Surgeons. Sharm El-Sheikh, Egypt. Feb 2010.

Podium presentation

European Burns Association Congress. Lausanne, Switzerland. Sep 2009. Podium presentation.

  • Full Thickness Burn Caused by Lithium Ion Battery in Mobile Phone

Rose AM, Raraty C, Hassan Z

British Burn Association (BBA). East Grinstead Apr 2010. Poster presentation.

Egyptian Society of Plastic and Reconstructive Surgeons. Sharm El-Sheikh, Egypt. Feb 2010.

Podium presentation.

European Burns Association Congress. Lausanne, Switzerland. Sep 2009. Poster presentation.

  • Reliability of Radiological Diagnosis for Thumb Duplication

Hassan Z, Rose AM, McArthur P

International Symposium on Paediatric Hand Surgery. Milan, Italy. Jan 2011. Poster presentation

XIV FESSH Congress. Poznan, Poland. Jun 2009. Poster presentation.

BAPRAS Summer Meeting. Leeds, UK. Jun 2009. Poster presentation.

  • Do excised Accessory Digits Require Specialty Follow-up?

Rose AM, Hassan Z, McArthur P

XIV FESSH Congress. Poznan, Poland. Jun 2009. Podium presentation.

Impact

Prizes and Awards

Syme Medal. Royal College of Surgeons of Edinburgh. 2018

Presidents Prize. British Association of Plastic Reconstructive and Aesthetic Surgeons Winter Meeting, London, 2017

Harold Elder Prize. University of Dundee, 2016

Best research presentation. Scottish Plastic Surgery Meeting. Dunkeld, Oct 2016.

PhD Poster Prize. College of Medicine, Dentistry and Nursing Annual Symposium. University of Dundee, Feb 2015.

Teaching

I am an active Advanced Trauma Life Support (ATLS) instructor.

Publications

Rose AM et al 2018. Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma. Oncotarget 2018. *Advanced Publications - In Press

Rose AM et al 2017. Patients with low-risk cutaneous squamous cell carcinoma do not require extended out-patient follow-up. J Plast Reconstr Aesthet Surg. 2017 Apr 6. pii: S1748-6815(17)30138-9. doi: 10.1016/j.bjps.2017.03.006. PMID: 28431856.

Rose AM, Sansom OJ and Inman GJ 2016. Loss of TGF-? receptors drives cSCC from skin stem cells – more evidence. Cell Cycle. 2017 Mar 4;16(5):386-387. doi: 10.1080/15384101.2016.1259892. PMID: 27860538.

Cammareri P*, Rose AM* and Vincent DF* et al. Inactivation of TGF-? receptors in skin stem cells drives cutaneous squamous cell carcinoma. Nature Communications. August 2016; 7: 12493. doi: 10.1038/ncomms12493. PMID: 27558455. * These authors contributed equally to this work

Rose AM, Nicoll KJ, Quaba O and Lowrie AG. E-cigarettes - beware of the rocket in your pocket. British Medical Journal, May 2016; 17;353:i2712. doi: 10.1136/bmj.i2712. PMID: 27189493.