Adrian Saurin

+44 (0)1382 383963
Senior Lecturer

Bio

Biography

Adrian graduated with first class honours from the University of Leeds in 1997 before moving to London to study for a PhD at Kings College in Professor Michael Marber’s laboratory at the Department of Cardiology. Following his PhD, Adrian moved to the Protein Phosphorylation laboratory at CRUK’s London Research Institute (headed by Professor Peter Parker), where he first became fascinated by the process of cell division. He subsequently moved to UMC Utrecht, in The Netherlands, to study the role of protein kinases during mitosis in the lab of Professor Geert Kops. Adrian relocated back to the UK in March 2013 to set up his own lab in Dundee studying the spatial regulation of mitotic signalling networks.

Teaching

I currently teach on the Cancer Biology modules for 3rd and 4th year undergraduate students. I also teach on the MRes and MSci postgraduate courses.

Research

In the lab we address fundamental questions about chromosome segregation in an effort to understand why this process goes wrong so frequently in tumour cells. We also focus on some basic cell signalling concepts that have widespread implications outside of cell division. In particular, we aim to uncover how kinases and phosphatases work together to control signal responses. This is important because this "signal integration" allows binary switch like responses to control complex biological outputs.

We use a range of approaches to tackle these problems, including quantitiative cell biology, synthetic biology, biochemistry and computation modelling. However, much of our day to day work involves single cell assays and microscopy: Seeing is believing.

For further information including an up-to-date list of project please visit: www.SaurinLab.com

 

Publications

Kinase and Phosphatase Cross-Talk at the Kinetochore
5/2018, Frontiers in Cell and Developmental Biology
Research Output: Contribution To Journal > Review article

The live cell DNA stain SiR-Hoechst induces DNA damage responses and impairs cell cycle progression
5/2018, Scientific Reports
Research Output: Contribution To Journal > Article

USP9X limits mitotic checkpoint complex turnover to strengthen the spindle assembly checkpoint and guard against chromosomal instability
3/2018, Cell Reports
Research Output: Contribution To Journal > Article

Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles
3/2018, Developmental Cell
Research Output: Contribution To Journal > Comment/debate

Author Correction
3/2018, Scientific Reports
Research Output: Contribution To Journal > Comment/debate

A fine balancing act
10/2017, International Journal of Biochemistry & Cell Biology
Research Output: Contribution To Journal > Review article

The Importance of Kinase-Phosphatase Integration
10/2017, Trends in Cell Biology
Research Output: Contribution To Journal > Review article

The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation
6/2017, Scientific Reports
Research Output: Contribution To Journal > Article

A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC
8/2017
Research Output: Contribution To Book Anthology > Chapter (peer-reviewed)

Studying kinetochore kinases
5/2016
Research Output: Contribution To Book Anthology > Chapter (peer-reviewed)

View full profile on research portal

Press

Dundee University cancer cell research funding boost

Adrian Saurin

22/01/16

1 item of media coverage

Press/Media: Research



Activities

Molecular Mechanisms of Mitosis (HBIGS Winter School)

Adrian Saurin (Speaker)
4 Feb 20197 Feb 2019

Activity: Talk or presentation typesInvited talk

Activity Type: Talk

Mechanisms & Models of Cancer. Cold Spring Harbor (New York, US).

Adrian Saurin (Speaker)
2018

Activity: Talk or presentation typesInvited talk

Activity Type: Talk

EMBO Dynamic Kinetochore Workshop (Edinburgh, UK).

Adrian Saurin (Speaker)
2017

Activity: Talk or presentation typesInvited talk

Activity Type: Talk

EMBO Europhosphatase: Phosphatases in Cell Fates and Decisions (Paris, France).

Adrian Saurin (Speaker)
2017

Activity: Talk or presentation typesInvited talk

Activity Type: Talk

Biochemical Society: Phosphatases and Signalling in Health and Disease (Bath, UK).

Adrian Saurin (Speaker)
2016

Activity: Talk or presentation typesInvited talk

Activity Type: Talk

EMBO Dynamic Kinetochore Workshop (Copenhagen, Denmark).

Adrian Saurin (Speaker)
2015

Activity: Talk or presentation typesInvited talk

Activity Type: Talk

Dynamic Kinetochore Workshop (Porto, Portugal).

Adrian Saurin (Speaker)
2013

Activity: Talk or presentation typesInvited talk

Activity Type: Talk