Work in the Division is spread over a number of core disease themes, which include cancer, diabetes and obesity, genome stability and neurodegenerative disorders.

Department strengths lie in the study of the molecular mechanisms, which regulate the Keap1/NRF2 signalling response in cancer and liver disease. The role of protein phosphatases in oncogenic signal transduction and in the control of key cell cycle transitions. Cellular signalling events that underpin the insulin response and metabolic homeostasis and molecular mechanisms that underpin the cellular response to stress including DNA damage and its consequences for human carcinogenesis, neurodegeneration and the response to targeted anti-cancer therapies.

Research teams are interdisciplinary and collaborative across themes and make use of a wide variety of state of the art techniques in biochemistry, molecular biology, proteomics, transcriptomics and the use of genetic models to gain insights into the molecular pathology of human disease.

Our goals are to discover novel biomarkers of disease processes and also to reveal novel therapeutic targets and disease-specific genetic vulnerabilities, which may be exploited to the benefit of patients.   

Key staff

Professor Kevin Hiom

Professor Kevin Hiom

Head of Division

Professor Albena Dinkova-Kostova

Professor Albena Dinkova-Kostova

Deputy Head of Division

Principal Investigators