21 Aug 2019

Forgotten cancer to be tackled by School scientists

The University of Dundee is to lead new research into a ‘forgotten cancer’ related to lifestyle and deprivation which Scots are more likely to be diagnosed with than almost any other group in the world. Russell Petty, Professor of Medical Oncology at the School of Medicine, has received £300,000 from the Chief Scientist Office to try and overcome resistance to treatment experienced by oesophageal squamous cell carcinoma (OSCC) patients. The problem of resistance is so serious that 60% of people die within a year of being diagnosed and only around 15% of patients are cured. While oesophage...

Forgotten cancer to be tackled by School scientists

21 Aug 2019

‘Yin and yang’ enzymes evolve over billions of years to help protect against cancer

Researchers at the School of Medicine have made an important discovery about two enzymes that have evolved over billions of years to control many different bodily functions, including playing a critical role in preventing cancer. The team, led by Dr Adrian Saurin, investigated the enzymes PP1 and PP2A which were known to be vital to the process of cell division, although the precise role they played has puzzled scientists until now. Cell division, also known as mitosis, sees a parent cell divide into two daughter cells containing the same DNA content. If this process goes wrong, and the DNA is not partitio...

‘Yin and yang’ enzymes evolve over billions of years to help protect against cancer

9 Aug 2019

Tuberculosis epidemic causes lasting damage to lungs

New research from the School of Medicine has revealed that the worldwide tuberculosis (TB) epidemic is leaving a legacy of chronic lung disease. Scientists from the School, in partnership with the Respiratory Research Network of India, have reported results from a study of more than 2000 Indian patients with evidence of permanent lung damage. Researchers have found that more than 1/3 of patients who are successfully cured of TB with antibiotics developed permanent lung damage which, in the worst cases, results in large holes in the lungs called cavities and widening of the airways called bronchiectasis. TB...

Tuberculosis epidemic causes lasting damage to lungs

26 Jul 2019

£2.1million grant to combat antimicrobial resistance

Researchers at the University of Dundee have been awarded £2.1million in funding to expand their work in the global battle against antimicrobial resistance, one of the major health problems facing the world in the 21st century. Antimicrobial resistance means existing treatments for some infections no longer work, creating an urgent need for new approaches to prevention and treatment. The funding award from the UK Government Department of Health and Social Care is to a team led by Dr Charis Marwick in the University’s School of Medicine, working with colleagues in the School of Life Science...

£2.1million grant to combat antimicrobial resistance

9 Jul 2019

Inhaling antibiotics improves chest infection symptoms

New research has identified that some patients with lung diseases could benefit from inhaling antibiotics directly into the lungs. The method, that uses a nebulizer to introduce antibiotics directly into the lungs, avoids many of the side effects of oral or injection medications. Scientists at the University of Dundee studied 440 patients with bronchiectasis, a chronic lung disease, who were randomly assigned to receive an antibiotic called aztreonam or a placebo for three months. By analysing the quantity of bacteria in the lungs, scientists were able to show that a group of lung disease patients who carr...

Inhaling antibiotics improves chest infection symptoms