10 Sep 2018

Study links widely-used drug azathioprine to skin cancers

A drug used to treat inflammatory bowel disease, arthritis and vasculitis as well as to prevent organ rejection in transplant patients has been identified as an important contributor to skin cancer development, in a research study carried out at the University of Dundee, Queen Mary University of London and the Wellcome Sanger Institute. The research, published in Nature Communications, identified a `strong case for an association’ between the drug azathioprine and the mutational signature found in cases of cutaneous squamous cell carcinoma (cSCC), a common form of skin cancer. It was already known th...

Study links widely-used drug azathioprine to skin cancers

6 Sep 2018

Removal of GP incentives associated with decline in quality of care

The removal of financial incentives for doctors working in primary care is associated with a decline in performance on quality measures, according to new findings by researchers from the Universities of Dundee and Cambridge, and staff from the National Institute for Health and Care Excellence (NICE). Researchers said the decline in performance measures may be partly accounted for by changes to documentation after incentives were removed. But they added that declines in measures involving laboratory testing suggested the removal of incentives had changed the actual care delivered to patients. Professor Bruc...

Removal of GP incentives associated with decline in quality of care

18 Jul 2018

Blood in stools may indicate range of chronic diseases

Faecal bleeding may be a marker of a range of chronic disease, including several cancers, previously thought to be unrelated, according to new research from the University of Dundee. The presence of blood in stools has long been associated with colorectal cancer. The new study, led by Professor Bob Steele of Dundee’s School of Medicine, has shown that patients who recorded a positive faecal occult blood test (FOBT) were much more likely to die not only from colorectal cancer but also a range of other diseases. Professor Steele and his team looked at data for 134,000 patients who have participated in ...

Blood in stools may indicate range of chronic diseases

13 Jul 2018

European Commission appoints School academic as independent expert

Dr Daniel Morales, who is a Discovery Fellow at the School of Medicine, has been appointed by the European Commission to be an independent scientific expert for the Pharmacovigilance Risk Assessment Committee (PRAC). The PRAC is the European Medicine Agency committee responsible for assessing and monitoring the safety of human medicines. Dr Morales’ role will involve being a member of the committee and providing scientific advice in order to help the assessment of all aspects of the risk management surrounding human medicine for around 600 million people across Europe. This includes the detection, as...

European Commission appoints School academic as independent expert

11 Jul 2018

Research could prompt changes in cancer treatment

Researchers at the University of Dundee have developed new drug modelling systems that could herald changes in the way patients are treated for the UK’s deadliest form of cancer. A team at the University’s School of Medicine say they have established a more accurate process of mimicking how anti-cancer medication metabolises in the human body, a move that could significantly benefit patients. It could lead to smaller, more targeted dosages of anti-cancer drugs being prescribed, reducing patient side-effects and allowing for more complex drug regimens to be tested to overcome the growing problem...

Research could prompt changes in cancer treatment