Our discoveries have led to new ways of diagnosing and treating major diseases such as cancer, diabetes and cardiovascular disease. Our research has changed clinical practice and has informed government policy and health guidelines.
The multicentre research study demonstrated that in patients with Bell’s Palsy early treatment with prednisolone significantly improved the chances of complete recovery at three and nine months.
The UK Faecal Occult Blood Test Screening Programme, based on Dundee-led research offers bowel cancer screening through mailed test kits followed up with colonoscopy when faecal blood is detected.
Our research on brain/B-type natriuretic peptide (BNP) has helped to diagnose both types of heart failure (systolic and diastolic heart failure) and to identify high-risk aortic stenosis patients for surgery.
Our research with spironolactone has advanced treatment in heart failure. We conducted the first “proof of concept” study to show that spironolactone had beneficial cardiac effects in man.
The discovery that loss-of-function mutations in the gene encoding filaggrin represent a strong risk factor for eczema, asthma and peanut allergy has defined a key pathological mechanism in atopic disease.
Though reducing deaths was a national priority, no systematic research into Scottish deaths had previously occurred. Highlighting the heterogeneity of the deceased, Dundee researchers identified deficits in care processes and multi-agency data sharing, making recommendations regarding monitoring.
An eight year MRC-funded clinical trial led by the University of Dundee and run throughout Scotland (16 hospitals, 188 GP Surgeries) exploring aspirin in diabetes for primary cardiovascular event prevention, where clinical practice had evolved without evidence.