The University of Dundee is home to a wide range of specialist facilities, enhancing our world-class research and enabling our engagement with industry.
Contact the individual facilities to find out more about how they can work with you.
Behavioural Neuroscience Core Facility
The Behavioural Neuroscience Core Facility provides investigators with the expertise and equipment to perform behavioural assessments. We have the capacity to perform behavioural phenotyping of transgenic lines and also assess novel therapeutics using a wide variety of behavioural assays and we can offer advice and expertise in experimental design, execution, data analysis and interpretation ensuring that each project is tailored to the specific research requirements of the user. The facility is available to university staff and students as well as external commercial and non-commercial users.
Biomarker and Drug Analysis Core Facility
The Biomarker and Drug Analysis Core Facility provides services in the analysis of soluble biomarkers, as well as drug compounds and metabolites (e.g. pharmacokinetic analysis). Services are offered to all University of Dundee staff and students as well as to other academic, commercial or not-for-profit institutions. There are a number of different modes of interaction with the Core Facility including tailored project advice, full service provision, project work involving facility staff and supported instrument access. The facility is equipped with state of the art Mass Spectrometry equipment: LC-MS/MS instruments for both quantitative and qualitative analysis of biomarkers and drug compounds.
Dr Jeffrey Huang, email@example.com
Clinical Research Imaging Facility
The Clinical Research Imaging Facility (CRIF) hosts state of the art PET/CT and 3T MRI scanners that are staffed by trained NHS personnel. The area also includes space for radio-pharmaceutical preparation, patient changing areas and a dedicated image analysis area.
Concrete Technology Unit (CTU)
The CTU's laboratories are some of the best equipped in the UK, offering a unique suite of techniques available for the characterisation of cement, concrete and other geological and industrial materials. The CTU's research and testing capabilities include:
- Material characterisation and particle analysis
- Concrete microstructural analysis
- Plastic and early age properties
- Operational and placement challenges
- Engineering, mechanical and NDT properties
- Thermal properties
- Durability, weathering and permeability
For more information:
Drug Discovery Unit
The University of Dundee Drug Discovery Unit is a fully operational, fully integrated drug discovery group working across multiple disease areas. We collaborate with partners to translate world-class biology research into novel drug targets and candidate drugs to address unmet medical need across our two areas of activity, Diseases of the Developing World and Innovative Targets Portfolio. Building on success in these areas we are also developing an Antibacterial Drug Discovery Accelerator.
Dundee Imaging Facility
The Dundee Imaging Facility has delivered excellence in a broad range of imaging technologies since 2002. Originally founded in the School of Life Sciences, the Imaging Facility has steadily grown its links to all aspects of the University’s scientific research programmes. Its growth is driven by scientific need— new technologies are added or expanded as required to support the research ambitions of our scientists. Our facilities include: Light Microscopy, 3D Structured Illumination, Tissue Imaging Facility, Electron Microscopy, Image Analysis, Physics and Life Sciences Lab, Histology and PHOQUS.
Dr Paul Appleton, P.L.Appleton@dundee.ac.uk
FingerPrints Proteomics Facility
The FingerPrints Proteomics Facility provides a state of the art Proteomics and Mass Spectrometry capability to researchers at the University of Dundee and to external academic and industrial clients across the globe.
- FingerPrints Proteomics Facility on the School of Life Sciences website
- FingerPrints Proteomics Facility website
Douglas Lamont, firstname.lastname@example.org
Flow Cytometry & Cell Sorting
The School of Life Sciences’ Flow Cytometry and Cell Sorting Facility provides research flow cytometry and fluorescence activated cell sorting (FACS) support to all investigators located within the School. The facilities are also available to other departments within the University of Dundee, as well as external research bodies.
Geotechnical Engineering Research Group
The Geotechnical Engineering Research Group's laboratories are unique within Scotland, offering well-equipped testing facilities that includes:
- Geotechnical centrifuge for scaled modelling
- Large scale 1g modelling tank and actuation systems
- Soil characterisation facilities
The available facilities are designed to allow low cost development of foundation and anchoring systems in a controllable and repeatable environment. They can also be used to simulate and verify working designs and installation.
For more information:
Health Informatics Centre
HIC Services supports high impact research through the collection & management of high quality data and operates a secure Safe Haven environment with strong data governance for the provisioning of data to academics and other users to improve healthcare and population health. HIC Services develops bespoke software to support secure data collection, provides recruitment support for clinical trials & manages a data entry service.
Human Pluripotent Stem Cell Facility
Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) have the potential to differentiate into every cell type in the human body and provide a powerful tool for life sciences and medical research in diverse fields such as cell and developmental biology, drug discovery, and regenerative medicine. The facility helps researchers to integrate the use of human pluripotent stem cells into their work and provides reagents and support for staff and students using them. The facility provides researchers with undifferentiated hESCs and hiPSCs, training in working with human pluripotent stem cells, and expertise in the development of cell based assays.
Dr Lindsay Davidson, email@example.com
Immunoassay Biomarker Core Laboratory
This Immunoassay Biomarker Core Laboratory handles, processes and analyses blood samples for biomarkers using various immunoassay techniques. This includes radio-immunoassay (RIA), enzyme-linked immuno-sorbent assay (ELISA) and multiplex assays (Luminex Bio-plex 200 platform and Meso Scale Discovery Quickplex SQ120). We also host the the Quanterix Simoa HD-1 analyser, the only ultra-sensitive automated platform in Scotland. If you have your own antibody-sets we can adapt them onto ultra-sensitive platforms and even multiplex with other existing biomarkers.
The Immunoassay Biomarker Core Laboratory also houses the School of Medicine two flow cytometers: Becton Dickinson LSRFortessa and Attune Acoustic Focusing flow cytometer.
- Immunoassay Biomarker Core Laboratory
MRC PPU Antibody Production
The MRC-PPU antibody production team are skilled in raising total and phosphospecific antibodies for MRC-PPU researchers as well as other external customers. The antibody production team has the capacity to raise antibodies for external customers and provides a complete service in which antigens can be designed and raised, coupled to BSA/KLH, injected into sheep and antibody appropriately affinity purified from each bleed and sent to customer for validation. Other species can also be employed.
MRC PPU Cloning
The MRC Protein Phosphorylation Unit (PPU) cloning team undertakes the majority of the molecular cloning required by MRCPPU researchers, as well as providing significant support to several external pharmaceutical collaborators. Much of our work feeds into the large collection of clones now available to all on our Reagents websites:
- For internal Dundee SLS researchers: sls-reagents.co.uk
- For external customers: mrcppureagents.dundee.ac.uk
The team also provide a custom cloning service to researchers in the rest of the School of Life Sciences, and externally to other academic researchers and companies.
Rachel Toth, firstname.lastname@example.org
MRC PPU DNA Sequencing and Services
MRC PPU DNA Sequencing and Services are a leading provider of a range of molecular biology services to academic and industry-based laboratories across the UK and worldwide. We use the latest cutting edge technologies, including the use of Qiagen Bio-Robots to automate bacterial plasmid DNA mini-preps. In addition to DNA sequencing, the service has the ability to run genotyping (fragment size analysis) samples of various types.
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets.
MRC PPU DUB Profiling provides access to DUB Profiling services at an affordable price, serving scientists in academia and industry the world over. Researchers at the University of Dundee MRC Protein Phosphorylation Unit have developed a sensitive and fast assay to quantify in vitro DUB enzyme activity using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Unlike other current assays, this method uses unmodified substrates, such as diubiquitin topoisomers.
MRC PPU International Centre for Kinase Profiling
The International Centre for Kinase Profiling provides access to kinase screening profiling services at an affordable price, serving scientists in academia and industry the world over. Researchers at The University of Dundee pioneered analysis of the selectivity of protein kinase inhibitors by setting up the first service to tackle this problem in 1998, and the International Centre for Kinase Profiling is now part of the largest and longest-running academic-industry partnership of its kind known as The Division of Signal Transduction Therapy.
MRC PPU Protein Production
The MRC PPU Protein Production Team provides recombinant proteins for Unit researchers, collaborators and external customers. The team’s capabilities include producing enzymes such as kinases or phosphatases, components of the ubiquitylation system, substrates, proteins for biophysical analysis or antigens to raise antibodies.
MRC PPU Proteomics and Mass Spectrometry
The MRC PPU Proteomics and Mass Spectrometry Team host several advanced Mass Spectrometry systems. The team processes the very high volume of samples generated by the Unit, and play a critical role in advising Unit researchers on the best way to generate samples for analysis. They also devote a lot of effort in maintaining all of our mass spectrometry systems in perfect working order and, most importantly, train our Unit staff in how to interpret the mass spectrometry data.
Dr Renata Filipe Soares, email@example.com
MRC PPU Reagents and Services
As one of the world's leading centres focused on cell signalling pathways, the MRC PPU Reagents and Services provides access to the very same reagents and services used by MRC PPU investigators to accelerate research worldwide. We can offer not only those reagents already made and tested by MRC PPU Investigators, but also contract research services for custom protein and antibody generation available to the wider research community.
National Phenotypic Screening Centre
National Phenotypic Screening Centre (NPSC) is a collaborative centre of excellence in phenotypic discovery sciences applied to human, animal and plant health. Staff in the industry-standard, state-of-the-art, facilities work closely with world-class academics and clinicians globally to develop complex biological assays that better reflect pathophysiology, thereby improving the likelihood of translation and have impact. NPSC can also access a range of target deconvolution technologies to take phenotypic small molecule hits forward. The University of Dundee hub incorporates:
- Fully-equipped HTS laboratory
- HighResBio screening platform within a BSL2 enclosure
- High Content Screening and High Throughput Flow Cytometry
- Large BSL2 cell culture suite
- Assay development and prep labs
- Access to 106,000 compound diversity library
- Image informatics and data analysis/visualisation
- High performance computing infrastructure
Visit the NPSC website for more details:
Dr Paul Andrews, firstname.lastname@example.org
Tayside Biorepository is part of the Scottish Biorepository network that has been established to try to bridge the gap within early stages of translational research by providing a streamlined approach to provide access to anonymised human tissue samples and associated clinical data collected during the routine patient pathway with NHS Scotland. Tayside Biorepository is an accredited bio-resource that can help to acquire a large range of prospectively collected fresh tissue, pathology Archive Material (FFPE), diagnostic & surgical surplus material, banked or pre-existing collections (frozen) and tissue microarrays (bespoke or previously constructed). In addition we can provide a large range of tissue services to help with the generation of data for research projects.
- Tayside Biorepository website
- Biorepositories and Tissue Services on the NHS Scotland Research website
Dr Sharon King, email@example.com
Tayside Centre for Genomic Analysis
The Tayside Centre for Genomic Analysis (TCGA) is a collaboration between the University of Dundee and NHS Tayside. The Centre benefits from expertise derived from The Pat MacPherson Centre for Pharmacogenomics and Pharmacogenetics, The East of Scotland Regional Genetics Service and The TCGA Unit. In operation since 1990, the Centre endeavours to deliver state-of-the-art facilities to researchers and clinicians involved in genetics and genomics. While the primary aim of the Centre is to provide services to the University of Dundee and NHS Trust Departments, the resources of the Centre are open to external groups, capacity permitting.
The service can provide:
- Next Generation Sequencing
- Sanger DNA Sequencing
- Real-Time PCR
- DNA/RNA Extraction Services
- Fragment Analysis
- Sequenome Analysis
- RNA DNA Protein QC Analysis
- Project Design
Dr. Kathy Walls, firstname.lastname@example.org.
Crystallography is the most powerful method for determining the atomic three dimensional structures of large biological molecules. The technique provides valuable information used to direct research projects throughout the College, where groups use X-ray crystallography to link protein structure with function and rational drug design.
Dr. Paul Fyfe, email@example.com
Wellcome Centre for Anti-Infectives Research (WCAIR)
The vision for the Wellcome Centre for Anti-Infectives Research (WCAIR) is to help tackle the urgent unmet medical need and lack of drug discovery research for Neglected Tropical Diseases (NTDs). This will be achieved by creating a world-leading hub for NTD drug discovery and being the collaborator of choice for academics, Pharma and Product Development Partnerships (PDPs) in the translation of discovery science into drug candidates.
WCAIR consolidates the existing world-leading NTD drug discovery expertise within the Division of Biological Chemistry and Drug Discovery bringing together the Drug Discovery Unit, the Mode of Action group and the Parasitology research groups providing an integrtaed pathway from discovery science to pre-clinical candidate selection.