Event
Solving a 3D jigsaw with 1000 pieces - structure, assembly and function of the nuclear pore
Thursday 12 October 2023
Discovery Seminar by Martin Beck, Max Planck Institute of Biophysics
University of Dundee
Dow Street
Dundee DD1 5HL
Venue: MSI, Large Lecture Theatre, SLS
Abstract
In eukaryotes, the genetic information is concealed into the nucleus that shields it from the cellular surroundings. Our research focuses on nucleocytoplasmic transport, i.e., how molecules are transported in and out of the nucleus. We use integrative, in situ structural biology techniques to study the structure, function, assembly and turnover of nuclear pore complexes in their native environment. I will discuss our investigation of the the scaffold architecture of the human nuclear pore, the physiological relevance of nuclear pore dilation and constriction movements inside of cells and state of the art cryo electron tomography techniques to analyse macromolecular assemblies at high resolution in situ.
FOLLOWED BY BUFFET RECEPTION IN CTIR THE STREET AT 1PM