Neuromodulatory control of spinal motor networks in health and disease

Friday 19 April 2024

MCDB Seminar by Prof Gareth Miles, University of St Andrews

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Friday 19 April 2024, 14:00 - 15:00
Medical Sciences Institute (MSI)

University of Dundee
Dow Street
Dundee DD1 5HL

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Host: Leeanne McGurk

Venue: MSI , Small Lecture Theatre, SLS

Summary: Networks of neurons within the spinal cord are sufficient to generate the complex neural output required to control rhythmic movements such as locomotion. These neural networks must adjust their output to suit ever-changing environmental and organismal demands. Our research aims to decipher the cellular mechanisms that enable motor control systems to function in an independent and adaptable manner. We have used a combination of molecular-genetic, live imaging and electrophysiological techniques, applied to isolated rodent spinal cord preparations, to reveal the mechanisms by which neuromodulatory pathways adjust the pattern and strength of motor network output. Our recent work has focussed on neuromodulatory pathways originating from spinal, cholinergic interneurons and spinal astrocytes. In parallel, we have investigated how changes in these neuromodulatory pathways can tip the scales towards neurodegeneration, as seen in devastating conditions such as Amyotrophic Lateral Sclerosis (ALS/MND).



Event type Talk
Event category Research