Dr Isla Mackenzie

Dr Isla Mackenzie

Position: Reader (Clinical)

Address: Medicines Monitoring Unit (MEMO), Ninewells Hospital and Medical School, Dundee

T: +44 (0) 1382 38 3119

isla@memo.dundee.ac.uk

Biography

Dr Isla Mackenzie MBChB (Honours) PhD FRCP Edin is a Clinical Senior Lecturer in Clinical Pharmacology and Honorary Consultant Physician at the University of Dundee and Ninewells Hospital, Dundee. Research interests include cardiovascular safety of drugs, clinical trials, hypertension and technology in research.

Clinical interests include general medicine, hypertension and adrenal disorders including phaeochromocytoma. Dr Mackenzie trained in Clinical Pharmacology in Cambridge prior to moving to Dundee in 2008.

Dr Mackenzie is a member of the British Hypertension Society Executive Committee, Honorary Secretary of the Scottish Society of Physicians and is Specialty Adviser in Clinical Pharmacology for Scotland.

Dr Isla Mackenzie is a Clinical Senior Lecturer in Clinical Pharmacology and Honorary Consultant Physician at the University of Dundee and Ninewells Hospital, Dundee. Research interests include cardiovascular safety of drugs, clinical trials, hypertension and technology in research. Clinical interests include general medicine, hypertension and adrenal disorders including phaeochromocytoma. Dr Mackenzie trained in Clinical Pharmacology in Cambridge prior to moving to Dundee in 2008.

Research

Dr Mackenzie’s research focuses on improving cardiovascular outcomes and drug safety using a combination of large multicentre randomised clinical trials and pharmacoepidemiological approaches to answer important clinical research questions.
 
She is also interested in clinical trial methodology and improving patient and physician engagement in clinical research.
 
She is Chief Investigator of the ALL-HEART study (involving 200 GP sites and 5,215 patients) and Principal Investigator of several other studies including FAST and FOURIER.

Publications

  • George J, Majeed W, Mackenzie IS, MacDonald TM, Wei L. The association of cardiovascular events with sodium-containing effervescent, dispersible and soluble medications; nested case-control study. British Medical Journal 2013; 347:f6954. doi: 10.1136/bmj.f6954 (26 Nov 2013)
  • Hapca A, Jennings C, Wei L, Wilson A, MacDonald TM, Mackenzie IS. Effectiveness of newspaper advertising for patient recruitment into a clinical trial. British Journal of Clinical Pharmacology 2013 (in press).
  • Mackenzie IS, Morant SV, Bloomfield GA, MacDonald TM, O’Riordan J. Incidence and prevalence of multiple sclerosis in the United Kingdom 1990-2010: A descriptive study in the General Practice Research Database. Journal of Neurology, Neurosurgery, and Psychiatry. Published Online First 19 Sept 2013 doi:10.1136/jnnp-2013-305450.
  • MacDonald TM, Mackenzie IS, Wei L, Hawkey CJ, Ford I. Methodology of a large prospective randomised open, blinded endpoint streamlined safety study of celecoxib versus traditional non-steroidal anti-inflammatory drugs in patients with osteoarthritis or rheumatoid arthritis: protocol of the Standard care versus Celecoxib Outcome Trial (SCOT). BMJ Open 2013 Jan 29;3(1). doi:pii: e002295. 10.1136/bmjopen-2012-002295. Print 2013.
  • Mackenzie IS, Wei L, MacDonald TM. Cardiovascular safety of lumiracoxib: a meta-analysis of randomized controlled trials in patients with osteoarthritis. European Journal of Clinical Pharmacology. 2013;69:133-141. [Epub 2012 Jun 26]. doi: 10.1007/s00228-012-1335-1.
  • Wei L, MacDonald TM, Mackenzie IS. Pioglitazone and bladder cancer: a propensity score matched cohort study. British Journal of Clinical Pharmacology 2013 Jan;75(1):254-9. doi: 10.1111/j.1365-2125.2012.04325.x.
  • Mackenzie IS, MacDonald TM, Thompson A, Morant S, Wei L. Spironolactone and risk of breast cancer: cohort study. British Medical Journal 2012 Jul 13;345:e4447. doi: 10.1136/bmj.e4447.
  • MacDonald TM, Mackenzie IS, Wei L. 2012. Novel ways to get good trial data: the UK experience. Discussion Paper, Institute of Medicine, Washington DC. (accessed May 18, 2012).
  • Rutherford D, Wei L, Mackenzie IS, MacDonald TM. The philosophy of doing observational medicines safety research. Journal of Clinical Research and Bioethics 2012; 3:131. doi:10.4172/2155-9627.1000131.
  • Mackenzie IS, Wei L, Paterson K, MacDonald TM. Cluster randomised trials of prescription medicines or prescribing policy – public and general practitioner opinions in Scotland. British Journal of Clinical Pharmacology 2012 Aug;74(2):354-61. doi: 10.1111/j.1365-2125.2012.04195.