TESTOSTERONE PATCHES (ANDROPATCH® )

AndropatchÒ is the trade name of a transdermal Testosterone Patch containing Testosterone 2.5 mg and 5 mg in each patch.

Testosterone is the male sex hormone which is produced in the testes (testicles) and which is responsible for regulating sexual function and other metabolic activity in men. It is underproduced in the condition known as male hypogonadism. AndropatchÒ is an adhesive patch with a central reservoir containing Testosterone which is released slowly across the skin (transdermally) for up to 24 hours after application. It is therefore a form of testosterone hormone replacement therapy (HRT) for men with hypogonadism.

Testosterone is not very effective if taken by mouth. It is however gradually absorbed into the circulation when applied to the skin surface as AndropatchÒ . The usual dose is one patch of strength 5 mg which is applied at night to a clean, dry area of the back, abdomen, upper arms, or thighs. The dose may be adjusted upwards to 7.5 mg (two patches containing 5 mg + 2.5 mg) or downwards to 2 .5 mg at night depending upon the individual’s response. Patches should be worn for 24 hours then replaced each night around 10 pm.

Apply the patch immediately on opening the pouch in which it is supplied and removing the protective liner. Press firmly in place with the palm of the hand exerting pressure for about 20 seconds. Check that there is good contact with the skin especially around the edges. Do not apply to bony areas (hips, shoulders), areas which will be subjected to prolonged pressure while sleeping or sitting, broken or damaged skin or to the scrotum.

What side effects can be expected?

• Some people are allergic to adhesives such as sticking plasters. Similarly the use of AndropatchÒ may rarely result in redness, itching or rash which develops at or around the site of application. You should therefore vary the site of application but if allergic reactions of this type persist and are troublesome, you should inform your Doctor.
• Occasionally there may be indigestion or a feeling of nausea.
• The administration of testosterone-like medicines may be accompanied by headaches, anxiety and mood changes. This is relatively rare but should be discussed with your doctor if it becomes a problem.
• There is a tendency for people to retain fluid and salt while on treatment. This would potentially aggravate hypertension (high blood pressure) and heart conditions such as angina or heart failure.
• Finally, because treatment can stimulate the growth of the prostate gland, you are likely to receive a prostate check up from time to time.

Testosterone and related medicines can increase the effect of warfarin (an anticoagulant) so increasing the risk of bleeding. This is only likely to be a problem when treatment is started and for a short period afterwards. It is easily overcome by adjusting the dose of warfarin.

Similarly, the effect of tablets which might be taken if you are diabetic (Glipizide, Gliclazide, Glibenclamide) can be increased again requiring possible re-adjustment of further treatment for diabetes.

Storing your medicine

AndropatchÒ transdermal patches should be stored in the original container in a cool place and not close to a radiator, fire, etc. Each patch should be removed and applied immediately.

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Ó NHS Tayside; 2006; version 1.0

Disclaimer; no liability whatsoever is accepted for information given and all such information, especially with regard to drug usage (UK version provided), must be checked with a person’s health provider.