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DIANETTEģ (CO-CYPRINDIOL) IN HIRSUTISM in women

(DIANETTEģ (CO-CYPRINDIOL) IN POLYCYSTIC OVARIAN DISEASE)

How does it work?
How do I take it?
What side effects can be expected?
Other medicines or substances which might interfere with your treatment
Storing your medicine

Available as tablets containing Cyproterone Acetate 2 mg + Ethinyloestradiol 35 microgram supplied under the trade name Dianette .

How does it work?

Cyproterone Acetate is an anti-androgen and blocks the normal activity of the small amount of male type hormone called androgen which every women normally produces and is necessary for axillary and pubic hair formation and maintenance. Cyproterone can be highly effective in many women with excess sexual sited hair (called hirsutism). Only a small dose is present in Dianette combined with the female type hormone ethinyloestradiol (an oestrogen). This may be sufficient for women with mild hirsutism - much higher doses are used in severe cases (see Cyproterone Acetate).

Cyproterone Acetate is also a potent progestational hormone (a second type of female sex hormone) and as such it inhibits the production of oestrogen. The addition of ethinyloestradiol compensates for the lack of oestrogen and the problems (hot flushes, menopausal-type symptoms) that would otherwise result. In relation to its component medicines, Dianette resembles the oral contraceptive and, indeed, acts as an oral contraceptive.

It can take up to one year of treatment with Dianette before the desired hair loss is achieved and it will be necessary to continue courses of treatment for as long as you wish to remain without excess hairs.

How do I take it?

Dianette is supplied in calender packs containing a 21 day treatment cycle. The treatment can be started at any time if you have not recently had a period or commenced on the first day of the menstrual cycle if you have. Take the dose at the same time each day (usually in the morning). On completion of each pack you should wait for 7 days before commencing the next one. You must follow these instructions precisely if you are using Dianette as a contraceptive. In such cases, if you do miss a dose it is important that you take this within 12 hours, otherwise additional contraceptive measures must be taken until your next treatment cycle.

What side effects can be expected?

The side effects of Dianette resemble those of the pill (it is after all an oral contraceptive) and include nausea and vomiting, indigestion, headaches, breast tenderness, changes in body weight, sexual desire and mood disturbances.

Other medicines or substances which might interfere with your treatment

Some medicines can reduce the effectiveness of Dianette when used as a contraceptive. These include certain antibiotics (especially Rifampicin) and anti-epileptic drugs (e.g. carmamazepine, Tegretol , phenytoin, Epanutin , etc). If in doubt, your Pharmacist can advise you.

Storing your medicine

No special requirements. This medicine can be stored at room temperature.

Top

Tayside University Hospitals NHS Trust; 2000; version 1.0

Disclaimer; no liability whatsoever is accepted for information given and all such information, especially with regard to drug usage (UK version provided), must be checked with a person’s health provider.

 

DIANETTEģ (CO-CYPRINDIOL) IN POLYCYSTIC OVARIAN DISEASE

How does it work?
How do I take it?
What side effects can be expected?
Other medicines or substances which might interfere with your treatment
Storing your medicine

Available as tablets containing Cyproterone Acetate 2 mg + Ethinyloestradiol 35 microgram supplied under the trade name Dianette .

How does it work?

Cyproterone Acetate is an anti-androgen. Androgen is the male type hormone which every women normally produces and is necessary for development of certain of the adult female characteristics (e.g. axillary and pubic hair formation and maintenance). In polycystic ovarian disease (PCO) there is substantial overproduction of androgen (hyperandrogenism) which is responsible for many of the symptoms of this condition. Cyproterone acetate by blocking the effect of androgen therefore reduces such problems in PCO.

Dianette contains a small dose of Cyproterone acetate combined with the female type hormone ethinyloestradiol (an oestrogen). Cyproterone Acetate is also a potent progestational hormone (a second type of female sex hormone) and as such it inhibits the production of oestrogen. The addition of ethinyloestradiol compensates for the lack of oestrogen and the problems (hot flushes, menopausal-type symptoms) that would otherwise result. In relation to its component medicines, Dianette resembles the oral contraceptive and, indeed, acts as an oral contraceptive.

How do I take it?

Dianette is supplied in calender packs containing a 21 day treatment cycle. The treatment can be started at any time if you have not recently had a period or commenced on the first day of the menstrual cycle if you have. Take the dose at the same time each day (usually in the morning). On completion of each pack you should wait for 7 days before commencing the next one. You must follow these insructions precisely if you are using Dianette as a contraceptive. In such cases, if you do miss a dose it is important that you take this within 12 hours, otherwise additional contraceptive measures must be taken until your next treatment cycle.

What side effects can be expected?

The side effects of Dianette resemble those of the pill (it is after all an oral contraceptive) and include nausea and vomiting, indigestion, headaches, breast tenderness, changes in body weight, sexual desire and mood disturbances.

Other medicines or substances which might interfere with your treatment

Some medicines can reduce the effectiveness of Dianette when used as a contraceptive. These include certain antibiotics (especially Rifampicin) and anti-epileptic drugs (e.g. carmamazepine, Tegretol , phenytoin, Epanutin , etc). If in doubt, your Pharmacist can advise you.

Storing your medicine

No special requirements. This medicine can be stored at room temperature.

Top

NHS Tayside; 2006; version 1.0

Disclaimer; no liability whatsoever is accepted for information given and all such information, especially with regard to drug usage (UK version provided), must be checked with a person’s health provider.