The major focus of clinically-based research is in cancers of the breast (Thompson), gastrointestinal tract (Steele, Wolf), and skin (Leigh, Proby, South). This is supported by extensive basic cancer research in genome damage (particularly the p53 pathway), stability and signalling mechanisms (Lane, Bourdon and colleagues, Meek, Fuller-Pace, Wright, Keyse, Clarke). Complementary research in immune signalling and antibody engineering related to cancer is carried out by an expanding group comprising Fagerholm, Matthews and Woof. This research theme has extensive Programme and Fellowship level support from Cancer Research
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