Publications
Recent Publications by DDRC members:
Beall C, Piipari K, Al-Quassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford MLJ. Loss of AMP-activated protein kinase a2 subunit in mouse ß-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J 429:323-333 (2010).
Bouskila, M., Hunter R. W., Ibrahim, A. F. M., Delattre, L., Peggie, M., van Diepen, J. A., Voshol, P. J., Jensen, J., Sakamoto, K. Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle. Cell Metab. In press (2010)
Burch LR, Donnelly LA, Doney AS, Brady J, Tommasi AM, Whitley AL, Goddard C, Morris AD, Hansen MK, Palmer CN. Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study. J Clin Endocrinol Metab. 95:1830-7 (2010).
Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford MLJ, Hayes JD. Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. Free Radic Biol Med 48:357-371 (2010) .
Deldicque L, Cani PD, Philp A, Raymackers J-M, Meakin PJ, Ashford MLJ, Delzenne NM, Francaux M, Baar K. (2010) The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the down-regulation of protein synthesis. Am J Physiol Endocrinol Metab (Epub ahead of print - 2010)
Dupuis J, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 42:105-16 (2010)
Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR, Nichols RJ. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localisation. Biochem J. Epub ahead of print (2010)
Flynn RW, Bonellie SR, Jung RT, MacDonald TM, Morris AD, Leese GP. Serum hyroid-Stimulating Hormone Concentration and Morbidity from Cardiovascular Disease and Fractures in Patients on Long-Term Thyroxine Therapy. J Clin Endocrinol Metab. 95: 186-93 (2010)
Foretz, M., Hebrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F. and Viollet, B. (2010). Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest. 120:2355-69 (2010)
Johnson, C., Crowther, S., Stafford, M. J., Campbell, D. G., Toth, R. and Mackintosh, C. 2010 Bioinformatic and experimental survey of 14-3-3-binding sites. Biochem J. 427:69-78 (2010)
Logie L, Ruiz-Alcaraz AJ, Schofield CJ, Hundal HS, Feuerstein GZ, Brady JD, Crowther D, Tommasi AM, Grierson CE, Shepherd B, Morris AD, Hansen MK, Pearson E, Sutherland C. Generation, validation and humanisation of a novel insulin resistant cell model Biochem Pharm. In Press (2010)
Luciano M, Batty DG, McGilchrist M, Linksted P, Fitzpatrick B, Jackson C, Pattie A, Dominiczak AF, Morris AD, Smith BH, Porteous D, Deary IJ. Shared Genetic aetiology between cognitive ability and cardiovascular disease risk factors: Generation Scotland’s Scottish Family Health Study. Intelligence 38: 304-313 (2010)
Nichols J, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott A, Alessi DR. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease associated mutations and regulates cytoplasmic localisation. Biochem J. Epub ahead of print (2010)
Pearce LR, Komander D, Alessi DR. The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol. 11:9-22 Review (2010)
Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanović S, Jovanović A, O'Shaughnessy KM, Alessi DR. Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med. 2:63-75 (2010)
Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM. Genetic association analysis of LARS2 with type 2 diabetes. Diabetologia. 53:103-10 (2010)
Repapi E, et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 42:36-44 (2010)
Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L. Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. Am J Physiol Endocrinol Metab. 298:E761-9 (2010)
Saxena R, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 42:142-8 (2010)
Treweek S, Pearson E, Smith N, Neville R, Sargeant P, Boswell B, Sullivan F. Desktop software to identify patients eligible for recruitment into a clinical trial: using SARMA to recruit to the ROAD feasibility trial. Inform Prim Care. 18:51-8 (2010)
Vella S, Buetow L, Royle P, Livingstone S, Colhoun HM, Petrie JR. The use of metformin in type 1 diabetes: a systematic review of efficacy. Diabetologia. 53:809-20 (2010)
Witham MD, Dove FJ, Dryburgh M, Sugden JA, Morris AD, Struthers AD. The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial. Diabetologia. Epub ahead of print (2010)
Zhou K, Donnelly L, Burch L, Tavendale R, Doney AS, Leese G, Hattersley AT, McCarthy MI, Morris AD, Lang CC, Palmer CN, Pearson ER. Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study. Clin Pharmacol Ther. 87:52-6 (2010)
del.icio.us
digg
reddit
facebook
stumbleupon